A5101932921- Attention Deficit Hyperactivity Disorder
- Immune cells in cancer
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Diet and metabolism studies
- Neural and Behavioral Psychology Studies
- Nutritional Studies and Diet
- Esophageal and GI Pathology
- Neuroblastoma Research and Treatments
- Intestinal Malrotation and Obstruction Disorders
- Toxin Mechanisms and Immunotoxins
- Proteoglycans and glycosaminoglycans research
- Psychology of Development and Education
- Gestational Trophoblastic Disease Studies
- Atomic and Molecular Physics
- Bacterial Infections and Vaccines
- Eating Disorders and Behaviors
- Aerodynamics and Acoustics in Jet Flows
- Inflammation biomarkers and pathways
- Exercise and Physiological Responses
- Cognitive Abilities and Testing
- Molecular Spectroscopy and Structure
- Congenital Diaphragmatic Hernia Studies
- Tryptophan and brain disorders
- Polysaccharides and Plant Cell Walls
Fudan University
2019-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2019-2025
Huashan Hospital
2025
Shanghai Institute for Science of Science
2019-2024
Novartis (France)
2020
Neurim Pharmaceuticals (Israel)
2020
Lundbeck (Denmark)
2020
Cambridge Cognition (United Kingdom)
2020
XinHua Hospital
2018-2020
Shanghai Jiao Tong University
2008-2020
Myeloid-derived suppressor cells (MDSCs) represent heterogeneous immunosuppressive in multiple cancer types and display potent activity on T cells. We have shown the increased expression of IDO breast cancer. Because plays a pivotal role immune tolerance via suppressing cell function, aim this study was to investigate MDSCs its MDSC-mediated inhibition surveillance. The proportion with phenotype CD45(+)CD13(+)CD33(+)CD14(-)CD15(-) significantly primary tissues patients' peripheral blood....
Abstract Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) define neuropsychopathological (NP) across externalizing internalizing symptoms using multitask connectomes. We demonstrate that NP might represent unified, genetically determined,...
Abstract Food preferences significantly influence dietary choices, yet understanding natural patterns in populations remains limited. Here we identifiy four subtypes by applying data-driven approaches to food-liking data from 181,990 UK Biobank participants: ‘starch-free or reduced-starch’ (subtype 1), ‘vegetarian’ 2), ‘high protein and low fiber’ 3) ‘balanced’ 4). These varied diverse brain health domains. The individuals with a balanced diet demonstrated better mental superior cognitive...
Abstract Bumetanide has been reported to alter synaptic excitation–inhibition (E-I) balance by potentiating the action of γ-aminobutyric acid (GABA), thereby attenuating severity autism spectrum disorder (ASD) in animal models. However, clinical evidence its efficacy young patients with ASD is limited. This was investigated present trial 83 patients, randomised bumetanide group (bumetanide treatment, 0.5 mg twice daily) or control (no treatment). Primary [Children Autism Rating Scale...
Attention-deficit/hyperactivity disorder (ADHD) comorbid with sleep disturbances can produce profound disruption in daily life and negatively impact quality of both the child family. However, temporal relationship between ADHD impairment is unclear, as are underlying common brain mechanisms.
Mounting evidence suggests hierarchical psychopathology factors underlying psychiatric comorbidity. However, the exact neurobiological characterizations of these multilevel remain elusive. In this study, leveraging brain-behavior predictive framework with a 10-year longitudinal imaging-genetic cohort (IMAGEN, ages 14, 19 and 23, N = 1,750), we constructed two neural externalizing internalizing symptoms, which were reproducible across six clinical population-based datasets (ABCD, STRATIFY/...
While increasing peripheral mechanisms related to chronic pain, the plasma proteomics profile associated with it and its prognosis remains elusive. This study utilizes 2923 proteins pain of 51 644 participants from UK Biobank finds 474 linked in six sites: head, neck or shoulder, back, stomach abdominal, hip, knee, 11 sharing across sites. The identified are largely enriched immune metabolic pathways highly expressed tissues like lungs small intestines. Phenome-wide analysis highlights...
Objective: The dual-pathway model has been proposed to explain the heterogeneity in symptoms of attention deficit hyperactivity disorder (ADHD) by two independent psychological pathways based on distinct brain circuits. authors sought test whether hypothesized cognitive and motivational have separable neural correlates. Methods: In a longitudinal community-based cohort 1,963 adolescents, neuroanatomical correlates ADHD were identified voxel-wise association analysis then validated using an...
Abstract Background The relationship between food allergy and respiratory attention‐deficit/hyperactivity disorder ( ADHD ) in children is rarely investigated. objective of this study was to determine whether early symptoms are associated with the prevalence Chinese school‐age children. Methods This cross‐sectional conducted using cluster‐stratified methods from 9 cities across China November December 2005. A family social environmental questionnaire including diagnosis history allergic...
This study aimed to evaluate the efficacy of bowel plication as a part surgical treatment in neonatal high jejunal atresia.Between January 2013 and December 2016, 43 neonates with atresia underwent at Children's Hospital Fudan University. According procedures patients underwent, were divided into group nonplication group. Eighteen proximal after atretic segment resection primary anastomosis. The other 25 enteroplasty resection. Data retrospectively analyzed, including gestational age, birth...
Using a simplified multi-configuration Dirac–Fock (SMCDF) scheme based on the (MCDF) theory, we study systematic variations of fine-structure splittings n2D3/2,5/2 Rydberg series along sodium-like isoelectronic sequence, i.e. orderings vary with increasing atomic number Z. The competition between spin-orbit interactions and exchange due to relativistic effects nd orbital wavefunctions well explain such variations. Furthermore, effect Breit which plays secondary role is studied.
Objective: To investigate the impact of allergic airway diseases on risk attention deficit hyperactivity disorder (ADHD) in school-age children. Method: Used stratified cluster sampling method, children first to sixth grade primary schools 9 randomly selected cities including Shanghai, Guangzhou, Xi'an, and Wuhan were enrolled study. Interview parents with questionnaires, which included individual family social environment questionnaire (including history diagnosed ADHD, rhinitis, bronchial...
Basic fibroblast growth factor (FGF-2) and saporin were chemically conjugated using the crosslinker, N-succinimidyl-3(2-pyridyldithio)-propionate. When purified, conjugate was found to be heterogeneous as analyzed by SDS/PAGE, size-exclusion HPLC reverse-phase HPLC. Therefore, we sought synthesize a molecule that would homogeneous thus easier characterize evaluate its efficacy toxicity for pharmaceutical drug development. A chemical successfully synthesized mutant FGF-2 with Cys96 replaced...
Abstract It is unclear how different diets may affect human brain development and if genetic environmental factors play a part. We investigated diet effects in the UK Biobank data from 18,879 healthy adults discovered anti-correlated brain-wide grey matter volume (GMV)-association patterns between coffee cereal intake, coincidence with their constructs. The Mendelian randomisation approach further indicated causal effect of higher intake on reduced total GMV, which likely through regulating...
Objective To explore the recurring risk factors for sacrococcygeal teratoma (SCT) in children. Methods A retrospective review was conducted 107 SCT children between January 2003 and December 2012 at our hospital. Risk were identified by univariate multivariate analyses. Results Sixteen had a recurrence of median interval 16.25 (6-59) months after primary surgery. And Altman types recurrent tumors Ⅰ(n=8, 15.4%), Ⅱ(n=2, 10.5%), Ⅲ(n=1, 10.0%) Ⅳ(n=5, 31.3%). Histologically, there...
Abstract Objective To investigate health-related quality of life (HRQOL) in postoperative esophageal atresia (EA) patients and to identify its potential influencing factors. Methods A total 102 EA children who had previously visited our hospital participated this cross-sectional study. Basic data disease the were collected. The HRQOL was assessed by Pediatric Quality Life Inventory TM 4.0 (PedsQL 4.0) EA-QOL questionnaire. scores PedsQL calculated compared with demographically matched...
Objective To investigate the gene expression profiles of side population (SP) cells in human neuroblastoma SK-N-SH cells.Methods After staining cell line with Hoechst 33 342 dye,the SP and nonside (non-SP) were separated using flow cytometric sorting.The isolated from presented several stem properties.The mRNA measured by Affymetrix GeneChip oligonucleotide array.Results Among 53544 differentially expressed genes,3453 significantly upregulated more than 2 folds cells.Using signal interaction...