Erin Burke Quinlan
A5071744154- Functional Brain Connectivity Studies
- Genetic Associations and Epidemiology
- Attention Deficit Hyperactivity Disorder
- Advanced Neuroimaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Cognitive Abilities and Testing
- Cannabis and Cannabinoid Research
- Epigenetics and DNA Methylation
- Substance Abuse Treatment and Outcomes
- Genetics and Neurodevelopmental Disorders
- Prenatal Substance Exposure Effects
- Neurotransmitter Receptor Influence on Behavior
- Stroke Rehabilitation and Recovery
- Health, Environment, Cognitive Aging
- Heart Rate Variability and Autonomic Control
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Schizophrenia research and treatment
- Stress Responses and Cortisol
- Genomic variations and chromosomal abnormalities
- Obsessive-Compulsive Spectrum Disorders
- Birth, Development, and Health
- Health disparities and outcomes
- Autism Spectrum Disorder Research
National Institutes of Health
2023-2024
National Center for Complementary and Integrative Health
2022-2024
King's College London
2016-2023
Medical Research Council
2017-2023
Sheffield Teaching Hospitals NHS Foundation Trust
2023
Trinity College Dublin
2021
University of Vermont
2017-2021
Fudan University
2018-2021
Shanghai Center for Brain Science and Brain-Inspired Technology
2020-2021
University of California, Irvine
2014-2020
Objective This study was undertaken to better understand the high variability in response seen when treating human subjects with restorative therapies poststroke. Preclinical studies suggest that neural function, injury, and clinical status each influence treatment gains; therefore, current hypothesized a multivariate approach incorporating these 3 measures would have greatest predictive value. Methods Patients 6 months poststroke underwent battery of assessments before receiving weeks...
Valid biomarkers of motor system function after stroke could improve clinical decision-making. Electroencephalography-based measures are safe, inexpensive, and accessible in complex medical settings so attractive candidates. This study examined specific electroencephalography cortical connectivity as by assessing their relationship with deficits across 28 days intensive therapy. Resting-state were acquired four times using dense array (256 leads) 12 hemiparetic patients (7.3 ± 4.0 months...
Animal studies have shown that the adolescent brain is sensitive to disruptions in endocannabinoid signaling, resulting altered neurodevelopment and lasting behavioral effects. However, few investigated ties between cannabis use development humans.
Background. Although rehabilitation therapy is commonly provided after stroke, many patients do not derive maximal benefit because of access, cost, and compliance. A telerehabilitation-based program may overcome these barriers. We designed, then evaluated a home-based telerehabilitation system in with chronic hemiparetic stroke. Methods. Patients were 3 to 24 months poststroke stable arm motor deficits. Each received 28 days using delivered their home. day consisted 1 structured hour focused...
Novelty-seeking tendencies in adolescents may promote innovation as well problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability these individuals. Here we use a longitudinal design track 144 novelty-seeking at age 14 and 16 determine activity response predicts use. We find that diminished BOLD mesolimbic (ventral striatal midbrain) prefrontal cortical (dorsolateral...
EEG has been used to study acute stroke for decades; however, because of several limitations EEG-based measures rarely inform clinical decision-making in this setting. Recent advances hardware, recording electrodes, and software could overcome these limitations. The present examined how well dense-array (256 electrodes) EEG, acquired with a saline-lead net analyzed whole brain partial least squares (PLS) modeling, captured extent behavioral deficits varied relation injury. In 24 patients...
Rates of cannabis use among adolescents are high, and increasing concurrent with changes in the legal status marijuana societal attitudes regarding its use. Recreational is understudied, especially adolescent period when neural maturation may make users particularly vulnerable to effects Δ-9-tetrahydrocannabinol (THC) on brain structure. In current study, we used voxel-based morphometry compare gray matter volume (GMV) forty-six 14-year-old human (males females) just one or two instances...
Abstract The functional neuroanatomy and connectivity of reward processing in adults are well documented, with relatively less research on adolescents, a notable gap given this developmental period's association altered sensitivity. Here, large sample ( n = 1,510) adolescents performed the monetary incentive delay (MID) task during magnetic resonance imaging. Probabilistic maps identified brain regions that were reliably responsive to anticipation receipt, prediction errors derived from...
Genetic factors and socioeconomic status (SES) inequalities play a large role in educational attainment, both have been associated with variations brain structure cognition. However, genetics SES are correlated, no prior study has assessed their neural associations independently. Here we used polygenic score for attainment (EduYears-PGS), as well SES, longitudinal of 551 adolescents to tease apart genetic environmental development Subjects received structural MRI scan at ages 14 19. At time...
<h3>Importance</h3> Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) 2 (BP2) are associated with neurodevelopmental disorders. These structural variants present 0.5% to 1.0% of population, making BP1-BP2 site most prevalent known pathogenic copy number variation (CNV). It is unknown what extent this CNV influences brain structure affects cognitive abilities. <h3>Objective</h3> To determine association deletion duplication CNVs cortical...
Significance We characterize in humans a coordinated network of brain activity describing neurobehavioral correlates reward anticipation. The involves nodes striatal and cortical regions, which are preferentially associated with distinct externalizing behaviors—hyperactivity alcohol consumption—suggesting that the heterogeneity reward-related behaviors might be accounted for by different association patterns their connecting links. In genome-wide study node subsequent functional validation...
Replicating results (i.e. obtaining consistent using a new independent dataset) is an essential part of good science. As replicability has consequences for theories derived from empirical studies, it utmost importance to better understand the underlying mechanisms influencing it. A popular tool non-invasive neuroimaging studies functional magnetic resonance imaging (fMRI). While effect underpowered well documented, assessment interplay between sample size and task-based fMRI remains limited....
Deviation from normal adolescent brain development precedes manifestations of many major psychiatric symptoms. Such altered developmental trajectories in adolescents may be linked to genetic risk for psychopathology.
The orbitofrontal cortex (OFC) is implicated in depression. hypothesis investigated was whether the OFC sensitivity to reward and nonreward related severity of depressive symptoms. Activations monetary incentive delay task were measured IMAGEN cohort at ages 14 years (n = 1877) 19 1140) with a longitudinal design. Clinically relevant subgroups compared (high-severity group: n 116; low-severity 206) 14. medial exhibited graded activation increases reward, lateral had nonreward. In this...
Alcohol abuse is highly prevalent, but little understood about the molecular causes. Here, we report that Ras suppressor 1 (Rsu1) affects ethanol consumption in flies and humans. Drosophila lacking Rsu1 show reduced sensitivity to ethanol-induced sedation. We required adult nervous system for normal it acts downstream of integrin cell adhesion molecule upstream Ras-related C3 botulinum toxin substrate (Rac1) GTPase regulate actin cytoskeleton. In an preference assay, global loss causes high...
This study investigated the prevalence of disordered eating cognitions and behaviours across mid-adolescence in a large European sample, explored extent to which ratings were affected by informant (parent/adolescent), or sex age adolescent. The Development Well-Being Assessment was completed parent–adolescent dyads at 14 (n = 2225) again 16 1607) explore 7 disorder symptoms (binge eating, purging, fear weight gain, distress over shape/weight, avoidance fattening foods, food restriction,...
Background and Purpose— Patient heterogeneity reduces statistical power in clinical trials of restorative therapies. Valid predictors treatment responsiveness are needed, several have been studied with a focus on corticospinal tract (CST) injury. We performance 4 such measures for predicting behavioral gains response to motor training therapy. Methods— Patients subacute-chronic hemiparetic stroke (n=47) received standardized arm therapy, change Fugl-Meyer score was calculated from baseline 1...