A5101652419- Stroke Rehabilitation and Recovery
- Acute Ischemic Stroke Management
- Software Engineering Research
- Foot and Ankle Surgery
- Botulinum Toxin and Related Neurological Disorders
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cerebral Palsy and Movement Disorders
- Orthopedic Surgery and Rehabilitation
- Topic Modeling
- Musculoskeletal pain and rehabilitation
- Lower Extremity Biomechanics and Pathologies
- Software Testing and Debugging Techniques
- Pharmacogenetics and Drug Metabolism
- Bone fractures and treatments
- Scoliosis diagnosis and treatment
- Tendon Structure and Treatment
- Medical Imaging and Analysis
- Drug Transport and Resistance Mechanisms
- Bacterial Identification and Susceptibility Testing
- Software Reliability and Analysis Research
- Musculoskeletal Disorders and Rehabilitation
- Antimicrobial Resistance in Staphylococcus
- Advanced Neuroimaging Techniques and Applications
- Natural Language Processing Techniques
UC Irvine Health
2017-2025
Pfizer (United States)
1990-2024
University of California, Los Angeles
2008-2024
Phenikaa University
2024
Microsoft (Belgium)
2023
University of Manitoba
2023
Newport (United States)
2015-2023
Keck Hospital of USC
2023
Microsoft (United States)
2023
Microsoft Research (India)
2023
Robots can improve motor status after stroke with certain advantages, but there has been less emphasis to date on robotic developments for the hand. The goal of this study was determine whether a hand-wrist robot would function, and evaluate specificity therapy effects brain reorganization. Subjects chronic producing moderate right arm/hand weakness received 3 weeks that emphasized intense active movement repetition as well attention, speed, force, precision timing, included virtual reality...
ABSTRACT Linezolid has been associated with reversible myelosuppression. Clinical trial data were evaluated for anemia, thrombocytopenia, and neutropenia. Thrombocytopenia a slight increased risk anemia evident at ≥2 weeks of linezolid treatment. Hematologic abnormalities consistent mild, reversible, duration-dependent Appropriate monitoring is warranted use.
<h3>Importance</h3> Many patients receive suboptimal rehabilitation therapy doses after stroke owing to limited access therapists and difficulty with transportation, their knowledge about is often limited. Telehealth can potentially address these issues. <h3>Objectives</h3> To determine whether treatment targeting arm movement delivered via a home-based telerehabilitation (TR) system has comparable efficacy dose-matched, intensity-matched in traditional in-clinic (IC) setting, examine this...
Objective This study was undertaken to better understand the high variability in response seen when treating human subjects with restorative therapies poststroke. Preclinical studies suggest that neural function, injury, and clinical status each influence treatment gains; therefore, current hypothesized a multivariate approach incorporating these 3 measures would have greatest predictive value. Methods Patients 6 months poststroke underwent battery of assessments before receiving weeks...
Valid biomarkers of motor system function after stroke could improve clinical decision-making. Electroencephalography-based measures are safe, inexpensive, and accessible in complex medical settings so attractive candidates. This study examined specific electroencephalography cortical connectivity as by assessing their relationship with deficits across 28 days intensive therapy. Resting-state were acquired four times using dense array (256 leads) 12 hemiparetic patients (7.3 ± 4.0 months...
Most programmers make mistakes when writing code. Some of these are small and require few edits to the original program – a class errors recently termed last mile mistakes. These break flow for experienced developers can stump novice programmers. Existing automated repair techniques targeting this language-specific do not easily carry over new languages. Transferring symbolic approaches requires substantial engineering neural data retraining. We introduce RING, multilingual engine powered by...
Many therapies are emerging that aim to improve motor function in people with stroke. Identifying key biological substrates needed for treatment gains would help predict effects and maximize impact. The current study addressed the hypothesis behavioral from therapy targeting distal upper extremity predicted by structural integrity of system white matter tracts.Twenty-three subjects chronic left-sided stroke underwent robotic right extremity. MRI was obtained at baseline used outline infarct....
Background. Although rehabilitation therapy is commonly provided after stroke, many patients do not derive maximal benefit because of access, cost, and compliance. A telerehabilitation-based program may overcome these barriers. We designed, then evaluated a home-based telerehabilitation system in with chronic hemiparetic stroke. Methods. Patients were 3 to 24 months poststroke stable arm motor deficits. Each received 28 days using delivered their home. day consisted 1 structured hour focused...
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Inhibition of fatty acid amide hydrolase‐1 (FAAH1) and the subsequent elevation amides has been proposed as a strategy to induce analgesic properties cannabinoids without accompanying negative side effects such impairment in cognition, motor control predisposition psychoses. PF‐04457845 is potent selective irreversible FAAH1 inhibitor which shown elevate concentrations animal models responses behavioural suggestive analgesia. STUDY ADDS This study...
To address the most appropriate endogenous biomarker for drug–drug interaction risk assessment, eight healthy subjects received an organic anion transporting polypeptide 1B (OATP1B) inhibitor (rifampicin, 150, 300, and 600 mg), a probe drug cocktail (atorvastatin, pitavastatin, rosuvastatin, valsartan). In addition to coproporphyrin I, widely studied OATP1B biomarker, we identified at least 4 out of 28 compounds (direct bilirubin, glycochenodeoxycholate‐3‐glucuronide,...
Large pre-trained language models have been used to generate code,providing a flexible interface for synthesizing programs from natural specifications. However, they often violate syntactic and semantic rules of their output language, limiting practical usability. In this paper, we propose Synchromesh: framework substantially improving the reliability code generation. Synchromesh comprises two components. First, it retrieves few-shot examples training bank using Target Similarity Tuning...
Linezolid, an oxazolidinone antibiotic, has 100% oral bioavailability and favorable activities against gram-positive pathogens including multidrug-resistant staphylococci, enterococci, pneumococci. Safety assessments were conducted for 2,046 linezolid-treated patients 2,001 comparator drug-treated from seven controlled clinical trials comparing the of linezolid drugs nosocomial community-acquired pneumonia, skin structure infections, methicillin-resistant staphylococcal infections....
This paper describes the design of a robotic device - hand-wrist assisting device, or HWARD ("Howard") that can assist functional grasping and releasing movements stroke-impaired hand. The 3 degrees-of-freedom is pneumatically-actuated backdriveable. was guided by neurobiological principles motor learning, such as sensorimotor integration, movement repetition, environmental complexity, attention. Specifically, repetitive while allowing subject to feel real objects during therapy. use having...
This study presents preliminary results of a randomized controlled trial comparing novel passive arm orthosis training system, the Therapy Wilmington Robotic Exoskeleton (T-WREX), with conventional self-directed upper extremity exercises. Chronic stroke survivors (n = 23) moderate to severe limb hemiparesis trained three times per week for eight weeks minimal supervision from an occupational therapist. Both groups demonstrated significant improvements in movement ability according Fugl-Meyer...
Diabetic nephropathy (DN) is the leading cause of ESRD worldwide. Reduced bioavailability or uncoupling nitric oxide in kidney, to decreased intracellular levels pathway effector molecule cyclic guanosine monophosphate (cGMP), has been implicated progression DN. Preclinical studies suggest that elevating cGMP pool through inhibition cGMP-hydrolyzing enzyme phosphodiesterase type 5 (PDE5) might exert renoprotective effects To test this hypothesis, novel, highly specific, and long-acting PDE5...
Total ankle arthroplasty (TAA) is an increasingly selected treatment for end-stage arthritis; however, failure and revision of the tibial talar components remains issue. Although multiple risk factors have been shown to contribute early component revision, no study has looked at combining such into a predictive model that could potentially decrease rates improve implant survival. This aimed develop TAA based on patient characteristics, patient-reported outcomes (PROs), immediate...
Introduction: High doses of activity-based rehabilitation therapy improve outcomes after stroke, but many patients do not receive this for various reasons such as poor access, transportation difficulties, and low compliance. Home-based telerehabilitation (TR) can address these issues. The current study evaluated the feasibility an expanded TR program. Methods: Under supervision a licensed therapist, adults with stroke limb weakness received home-based (1 h/day, 6 days/week) delivered using...
Students often make mistakes on their introductory programming assignments as part of learning process. Unfortunately, providing custom repairs for these can require a substantial amount time and effort from class instructors. Automated program repair (APR) techniques be used to synthesize such fixes. Prior work has explored the use symbolic neural APR in education domain. Both types approaches either engineering efforts or large amounts data training. We propose language model trained code,...
Tofacitinib is a potent, selective inhibitor of the Janus kinase (JAK) family kinases with high degree selectivity within human genome's set protein kinases. Currently approved formulations for tofacitinib citrate are immediate‐release (IR) tablets, modified‐release (MR) and IR solution. A once daily MR microsphere formulation was developed use in pediatric patients. Demonstration bioequivalence (BE) between 10 mg (q.d.) 5 twice (b.i.d.) solution needed to enable exposure–response...
Introduction: Restorative therapies have maximal impact when introduced early post-stroke. Dopamine modulates learning and plasticity, its levels decrease after stroke, making it a key therapeutic candidate. For restorative therapy to promote experience-dependent concomitant training is needed must be provided experimentally given low rehabilitation doses received with usual care (UC); here this was using an established telerehabilitation (TR) system. Current hypotheses : [H1] Adding...
Abstract The 2023 Orthopaedic Trauma Association's Basic Science Focus Forum featured a symposium on additive manufacturing (AM) in orthopaedics. Three experts presented various aspects of AM: Dr. Malcolm DeBaun discussed custom 3D-printed implants for segmental bone loss, Samir Mehta explored 3D printing education and surgical planning, Guha Manogharan addressed challenges opportunities AM hybrid manufacturing. highlighted AM's significant impact across clinical, educational, industrial...
The study proposes a research model with two mediators, Perceived Ease of Use and Risk, to examine the impact Technophobia on Intention e-Government Vietnamese people. Through data analysis 265 samples collected from people nationwide, results found that has positive relationship Risk. In addition, direct between was not found. However, an indirect demonstrated through mediator Based results, authors propose state management agencies solutions reduce people's fear technology encourage use...
In the rim of tissue surrounding a cortical infarct, animal studies have described an increase in number growth-related processes that likely contribute to behavioral recovery. The current study hypothesized patients with good outcome after stroke, brain activation peri-infarct would be greater than normal.In 15 recovery chronically ischemic within was directly compared same 13 control subjects.Although most did show tissues, their controls reduced rather increased. Evaluation T2*-weighted...