A5029372052- Shoulder Injury and Treatment
- Orthopedic Surgery and Rehabilitation
- Tendon Structure and Treatment
- Orthopaedic implants and arthroplasty
- Bone fractures and treatments
- Shoulder and Clavicle Injuries
- Sports injuries and prevention
- Botulinum Toxin and Related Neurological Disorders
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Cancer Treatment and Pharmacology
- Elbow and Forearm Trauma Treatment
- Bone Tissue Engineering Materials
- Cardiovascular Syncope and Autonomic Disorders
- Spine and Intervertebral Disc Pathology
- Trauma Management and Diagnosis
- Nerve Injury and Rehabilitation
- Hip disorders and treatments
- Anatomy and Medical Technology
- Neurological disorders and treatments
- Muscle activation and electromyography studies
- Additive Manufacturing and 3D Printing Technologies
- Hip and Femur Fractures
- Foot and Ankle Surgery
- Orthopedic Infections and Treatments
University of Pennsylvania
2016-2025
University of Delaware
2024-2025
IU International University of Applied Sciences
2022-2024
California University of Pennsylvania
2018-2024
Merz (United States)
2022-2024
Philadelphia VA Medical Center
2020-2024
Hospital of the University of Pennsylvania
2023
MerLion Pharma (Germany)
2022-2023
GTx (United States)
2022
Philadelphia University
2022
Abstract Modern total knee arthroplasty (TKA) is an effective procedure to treat pain and disability due osteoarthritis, but some patients experience quadriceps weakness after surgery have difficulty performing important activities of daily living. The success TKA depends on many factors, malalignment the prosthetic components a major cause postoperative complications. Significant variability associated with femoral tibial component rotational alignment, how this translates into functional...
The goal of this cadaver study in cats was to compare the mechanical properties intact mandibles (C) with whose simulated fracture located between third and fourth premolar teeth repaired four possible treatments: (1) Stout multiple loop interdental wiring plus bis-acryl composite intraoral splint (S); (2) modified Risdon (R); (3) ultrasound-aided absorbable fixation plate (P); (4) mesh (M). Thirty feline were randomly assigned control treatment groups. Mandibles loaded by cantilever bending...
Recent advancements in additive manufacturing (AM) have motivated researchers to consider this fabrication technique as a solution for challenges patient-specific orthopaedic needs. Although there is an increasing trend the applications of AM medical fields, critical need understand biomechanical performance implants. In particular, design opportunities, anisotropic material properties and resulting stability implant constructs large bone defects such osteosarcoma, comminuted fractures...
Achilles tendon ruptures are common and devastating injuries; however, an optimized treatment rehabilitation protocol has yet to be defined. Therefore, the objective of this study was investigate effects surgical repair return activity on joint function properties after 3 weeks healing. Sprague-Dawley rats (N = 100) received unilateral blunt transection their tendon. Animals were then randomized into repaired or non-repaired treatments, further groups that returned 1 week (RTA1) (RTA3) limb...
The rapid shift towards online learning in higher education has transformed the landscape of essential academic skills, with presentation abilities emerging as a crucial competency for student success. This paper addresses challenges and opportunities associated teaching skills distance context. Traditional face-to-face interactions have been replaced by digital tools that, while offering unique benefits, also present significant hurdles skill acquisition. A five-step approach is outlined,...
Abstract The 2023 Orthopaedic Trauma Association's Basic Science Focus Forum featured a symposium on additive manufacturing (AM) in orthopaedics. Three experts presented various aspects of AM: Dr. Malcolm DeBaun discussed custom 3D-printed implants for segmental bone loss, Samir Mehta explored 3D printing education and surgical planning, Guha Manogharan addressed challenges opportunities AM hybrid manufacturing. highlighted AM's significant impact across clinical, educational, industrial...
Model-based estimation of in vivo contact forces arising between components a total knee replacement is challenging because such depend upon accurate modeling muscles, tendons, ligaments, contact, and multibody dynamics. Here we describe an approach to solving this problem with results that are tested by comparison loads measured for single subject made available through the Grand Challenge Competition Predict Tibiofemoral Loads. The makes use “dual-joint” paradigm which joint alternately...
Background: Over the past several decades, there has been a steady increase in pediatric anterior cruciate ligament (ACL) tears, particularly young female basketball and soccer players. Because allograft tissue for ACL reconstruction (ACLR) shown high rates of failure, autograft may be best option ACLR this population. However, differences structure mechanical behavior these tissues are not clear. Purpose: To characterize microstructural properties ACLs using rare cadaveric cohort (mean age,...
Abstract The meniscus plays a central load‐bearing role in the knee joint. Unfortunately, injury is common and can lead to joint degeneration osteoarthritis (OA). In small animal models, progressive degenerative changes occur with unloading of via destabilization medial (DMM). However, few large models DMM exist joint‐wide initiation disease has not yet been defined these models. Thus, goal this study develop validate model surgically induced use multimodal (mechanical, histological,...
This manuscript summarizes presentations of a symposium on key considerations in design biomechanical models at the 2019 Basic Science Focus Forum Orthopaedic Trauma Association. The first section outlines most important characteristics high-quality study. second considers choices associated with designing experiments using finite element modeling versus synthetic bones human specimens. third discusses appropriate selection experimental protocols and analyses. fourth pros cons use research...
Conventional microdiscectomy treatment for intervertebral disc herniation alleviates pain but does not repair the annulus fibrosus, resulting in a high incidence of recurrent and persistent dysfunction. The lack acute inflammation that arise after injury can further compromise result disc-wide degeneration long term. To address this clinical need, we developed tension-activated patches (TARPs) fibrosus local delivery anti-inflammatory factor anakinra (a recombinant interleukin-1 receptor...
a rat model of supraspinatus overuse has suggested mechanisms governing tendon degeneration; however, delineating which changes are pathologic or simply physiologic adaptations to increased loading remains question. The objective this study was develop and characterize exercise that induces systemic local shoulder without mechanical injury the tendon.exercise rats completed treadmill training protocol for 12 weeks. Body, fat pad, heart weights were determined. Supraspinatus collagen content,...
Exercise protocol induces muscle, tendon, and bone adaptations in the rat shoulder tendon collagen content, cross-sectional area, mechanical properties were measured.Supraspinatus muscle weight, expression of mitochondrial oxidative phosphorylation (OXPHOS) proteins measured.Humeri analyzed with μCT mechanically tested.Results: exercise decreased fat pad mass.Supraspinatus hypertrophied had increased OXPHOS proteins.Humerus trabecular anisotropic orientation, cortical showed tissue mineral...
Abstract The biological mechanisms regulating tenocyte differentiation and morphological maturation have not been well-established, partly due to the lack of reliable in vitro systems that produce highly aligned collagenous tissues. In this study, we developed a scaffold-free, three-dimensional (3D) tendon culture system using mouse cells differentially adherent growth channel. Transforming Growth Factor-β (TGFβ) signaling is involved various processes tendon, cell fate, recruitment...