A5003528434- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Pancreatic and Hepatic Oncology Research
- Synthesis and Biological Activity
- Carbohydrate Chemistry and Synthesis
- Radiomics and Machine Learning in Medical Imaging
- Diverse Approaches in Healthcare and Education Studies
- Bioactive Compounds and Antitumor Agents
- Bone and Dental Protein Studies
- Proteoglycans and glycosaminoglycans research
- Advanced biosensing and bioanalysis techniques
- Connective tissue disorders research
- Asymmetric Hydrogenation and Catalysis
- Chemical synthesis and alkaloids
- Nanoparticle-Based Drug Delivery
- Diverse Topics in Contemporary Research
- Seaweed-derived Bioactive Compounds
- Natural product bioactivities and synthesis
- Enzyme Production and Characterization
- Synthesis and Catalytic Reactions
- X-ray Diffraction in Crystallography
- Autophagy in Disease and Therapy
Georgia Institute of Technology
2024-2025
Korea Institute of Ocean Science and Technology
2016-2025
Korea University of Science and Technology
2014-2025
Seoul National University Bundang Hospital
2018-2025
Dankook University
2025
Gilead Sciences (United States)
2023-2025
The University of Texas MD Anderson Cancer Center
2016-2024
CHA Bundang Medical Center
2024
CHA University
2021-2024
University of Pennsylvania
2022-2024
Background: Simvastatin has been shown to increase bone growth when applied topically murine bone; however, it causes considerable soft tissue inflammation at high doses (2.2 mg), making future clinical use problematic. This study evaluated the effect of lower simvastatin and cyclooxygenase (COX) synthase inhibitors on in rats gene expression mice. Methods: Adult female were untreated or treated with a single dose 0.1, 0.5, 1.0, 1.5, 2.2 mg methylcellulose gel polylactic acid membrane (SIM)...
Early diagnosis of the highly pathogenic H5N1 avian influenza virus (AIV) is significant for preventing and controlling a global pandemic. However, there no existing electrical biosensor detecting biomarkers AIV in clinically relevant samples such as chicken serum. Herein, we report first use an aptamer-functionalized field-effect transistor (FET) label-free sensor detection A DNA aptamer employed sensitive selective receptor hemagglutinin (HA) protein, which biomarker AIVs. This immobilized...
Abstract Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with variable presentations and natural histories of disease. We hypothesized that different morphologic characteristics PDAC tumors on diagnostic computed tomography (CT) scans would reflect their underlying biology. Experimental Design: developed quantitative method to categorize the morphology pretherapy CT from multiple datasets patients resectable metastatic correlated these patterns clinical/pathologic...
Stereogenic-at-Mo monoalkoxide and monoaryloxide complexes promote enyne ring-closing metathesis (RCM) reactions, affording the corresponding endo products with high selectivity (typically >98:<2 endo:exo). All catalysts can be prepared used in situ. Five-, six-, seven-membered rings are obtained through reactions substrates that bear all-carbon tethers as well those contain heteroatom substituents. The newly developed catalytic protocols complement related exo-selective Ru-catalyzed...
Concerning the requirements of effective drug candidates to combat against high rising multidrug resistant pathogens, we isolated three new linear lipopeptides, gageostatins A–C (1–3), consisting hepta-peptides and 3-β-hydroxy fatty acids from fermentation broth a marine-derived bacterium Bacillus subtilis. Their structures were elucidated by analyzing combination extensive 1D, 2D NMR spectroscopic data resolution ESIMS data. Fatty acids, namely 3-β-hydroxy-11-methyltridecanoic...
Dramatic increases in reaction rates and enantioselectivities can be effected by the use of surfactants for phase-transfer catalytic epoxidation aromatic enones. Based on X-ray crystal structure most effective catalyst—a modified cinchona alkaloid—a plausible transition state has been modeled (see picture; HOO− yellow, C gray, H white, N blue, O red). Supporting information this article is available WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z462254_s.pdf or from author. Please...
Silver nanoparticles made easy: A simple, effective, and one-pot method toward the synthesis of a defined macrocycle–silver nanoparticle system in water has been described (see figure). Interestingly, cucurbituril (CB)[7]-protected AgNPs showed significantly increased cytotoxicity against MCF-7 NCI-H358 cancer cells, as demonstrated by models vitro. Detailed facts importance to specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or...
Gageotetrins A–C (1–3), a unique class of linear lipopeptides, consisting di- and tetrapeptides new fatty acid were isolated from Marine Bacillus subtilis. The structures 1–3 assigned by spectroscopic data their absolute stereochemistries ascertained chemical derivatization. Compounds displayed good antimicrobial activities with MIC values 0.01–0.06 μM. However, these compounds failed to register any cytotoxicity (GI50 > 30 μg/ml) against human cancer cell lines.
To determine the biological activity of Rhodiola rosea, protein expression iNOS and proinflammatory cytokines was measured after activation murine microglial BV2 cells by LPS under exposure constituents rosea: crude extract, rosin, rosarin, salidroside (each 1-50 μ g/mL). The LPS-induced in suppressed rosea a concentration-dependent manner. Also factors iNOS, IL-1 β , TNF- α kidney prefrontal cortex brain mice oral administration extract (500 mg/kg). neuroprotective effect neuronal were...
Ecofriendly cation metal oxide quantum dots (QDs) are one of the promising candidates to replace for QDs containing expensive indium (In) or hazardous Cd- and Pb-elements. Super-Eg excitation wavelength (λex) dependent Zni-VO complex defects related characteristic emissions green, yellow, orange-red from ZnO completely inhibited by reducing oxygen vacancies through hybridization Zn interstitials in with antibonding O-states graphene (GO) QDs. Thus, only λex independent violet-purple-blue...
Abstract Background Inappropriate antibiotic use, particularly prolonged courses, is a significant driver of resistance. This study aimed to evaluate the impact targeted antimicrobial stewardship program (ASP) intervention on utilization, resistance, and costs in patients receiving antibiotics for more than 15 days. Monthly changes DOT per 1000 patient-days over span 5 years Methods We employed an adult inpatients days since August 2018. An ASP team pharmacists infectious disease physicians...
Abstract Studies of protective factors regarding the suicidal risk in individuals with depression commonly suggest that social resources are important. However, there some incoherent results may be due to cognitive distortion depressed people. Therefore, purpose this study was explore relationship using network variables, a relatively objective measurement method. The 145 participants were college students who studied Seoul, South Korea. Center for Epidemiologic Depression Scale (CES‐D),...
Objectives The purpose of this study is to analyze the effect university students’ self-leadership on interpersonal competence and verify whether stress coping strategies mediate relationship. Methods A structured self-report survey was conducted with 205 students enrolled from first fourth year at a in C region April 10 May 15, 2024. collected data were analyzed using SPSS Statistics 26.0, through t-tests, ANOVA, Pearson’s correlation coefficients, multiple regression analysis, Macro...