A5100414528- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Protein Hydrolysis and Bioactive Peptides
- Synthesis and Catalytic Reactions
- Free Radicals and Antioxidants
- Asymmetric Hydrogenation and Catalysis
- Proteins in Food Systems
- Electrocatalysts for Energy Conversion
- RNA and protein synthesis mechanisms
- Synthetic Organic Chemistry Methods
- Job Satisfaction and Organizational Behavior
- Polymer Surface Interaction Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Organic Chemistry Cycloaddition Reactions
- Enzyme Structure and Function
- Ion Channels and Receptors
- RNA modifications and cancer
- Synthesis of β-Lactam Compounds
- Carbohydrate Chemistry and Synthesis
- Peptidase Inhibition and Analysis
- Advanced battery technologies research
- Advanced Photocatalysis Techniques
- Knowledge Management and Sharing
- Food and Agricultural Sciences
- Fluorine in Organic Chemistry
Gangnam Severance Hospital
2020-2022
Yonsei University
2020-2022
Seoul National University
2012-2022
Ajou University
2022
Government of the Republic of Korea
2020
Seoul Institute
2020
Kangwon National University
2019
Creative Research
2017-2018
CHA University
2017
The University of Tokyo
2016
A tRNA synthase in metabolic control Leucyl-tRNA synthetase 1 (LARS1), which covalently couples leucine to its cognate transfer RNAs (tRNAs), appears have broader roles the of metabolism. The enzyme also serves as a sensor for mechanistic target rapamycin complex (mTORC1), regulates protein synthesis, metabolism, autophagy, and cell growth. Yoon et al. show that cells deprived glucose, LARS1 is phosphorylated by Unc-51 like autophagy activating kinase (see Perspective Lehman Abraham). This...
Dramatic increases in reaction rates and enantioselectivities can be effected by the use of surfactants for phase-transfer catalytic epoxidation aromatic enones. Based on X-ray crystal structure most effective catalyst—a modified cinchona alkaloid—a plausible transition state has been modeled (see picture; HOO− yellow, C gray, H white, N blue, O red). Supporting information this article is available WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z462254_s.pdf or from author. Please...
A novel enantioselective synthetic method for the construction of a quaternary carbon center from malonates via phase-transfer catalytic (PTC) alkylation has been developed. The asymmetric α-alkylation diphenylmethyl tert-butyl α-alkylmalonates with alkylating agents under catalysis conditions (aq 50% KOH, toluene, 0°C) in presence (S,S)-3,4,5-trifluorophenyl-NAS bromide (8) as PTC catalyst afforded corresponding α,α-dialkylmalonates high chemical (up to 99%) and optical yields 97% ee) which...
Abstract Free‐standing nanoparticle films are of great importance for developing future nano‐electronic devices. We introduce a protein‐based fabrication strategy free‐standing monolayer films. α‐Synuclein, an amyloidogenic protein, was utilized to yield tightly packed gold‐nanoparticle film interconnected by protein β‐sheet interactions. Owing the stable protein–protein interaction, successfully expanded 4‐inch diameter sheet, which has not been achieved with any other monolayers. The...
This study investigates why and when coworker knowledge sharing encourages employee voice behavior by exploring psychological safety as a mediator promotion focus moderator. We tested the hypotheses using 68 dyads (study 1) 289 2) collected from South Korea. In both studies, we found positive indirect relationship between through safety. Moreover, in Study 2, examined how moderates effects of on via The implications directions for future research are discussed.
Background/Objectives: C24 ceramide plays a crucial role in skin regeneration and wound healing; however, its hydrophobic nature limits application therapeutic formulations. This study aims to enhance the bioavailability efficacy of by developing ceramide-based lipid nanoparticles (C24-LNP) evaluate their impact on healing. Methods: C24-LNP was synthesized characterized for aqueous stability bioavailability. In vitro experiments were conducted assess effects keratinocyte proliferation...
Highly enantioselective synthesis of a potent metabotropic receptor ligand, (2S)-α-(hydroxymethyl)-glutamic acid (2, HMG) was accomplished by the catalytic Michael addition 2-naphthalen-1-yl-2-oxazoline-4-carboxylic tert-butyl ester (3b), using phosphazene base, BEMP, in CH2Cl2 at −60 °C presence (S)-binaphthyl quaternary ammonium salt 4.
Chemical investigation of a Korean marine sponge, Monanchora sp., yielded nine new sesterterpenoids (1–9) along with phorbaketals A–C (10–12). The planar structures were established on the basis NMR and MS analysis, absolute configurations 1–9 defined using modified Mosher's method CD spectroscopic data analysis. Compounds 1–8, designated as D–K, possess spiroketal-modified benzopyran moiety such phorbaketal A, their structural variations are due to oxidation and/or reduction tricyclic core...
A highly enantioselective synthetic method for (R)-α-alkylserines was developed by the phase-transfer catalytic alkylation of o-biphenyl-2-oxazoline-4-carboxylic acid tert-butyl ester (4i) using cinchona-derived catalyst N(1)-(9-anthracenylmethyl)-O(9)-allyl-dihydrocinchonidinium bromide (up to 96% ee).
The phase-transfer catalytic alkylation of N,N-dialkylmalonamic tert-butyl esters in the presence 1 mol% (S,S)-3,4,5-trifluorophenyl-NAS bromide afforded highly enantioselective (S)-mono-α-alkylated products (up to 96% ee), which could be readily converted into versatile chiral building blocks without loss chirality.
An enantioselective synthetic method for α-alkylserines by the phase-transfer catalytic alkylation of 2-phenyl-2-oxazoline-4-carbonylcamphorsultam (4a) was developed. The α-alkylation 4a using P2-Et at −78 °C gave (75∼99%, 90∼97% de), which could be easily hydrolyzed to α-alkylserines.
Abstract Recent development of the chemical inhibitors specific to oncogenic KRAS (Kirsten Rat Sarcoma 2 Viral Oncogene Homolog) mutants revives much interest control KRAS-driven cancers. Here, we report that AIMP2-DX2, a variant tumor suppressor AIMP2 (aminoacyl-tRNA synthetase-interacting multi-functional protein 2), acts as cancer-specific regulator stability, augmenting tumorigenesis. AIMP2-DX2 specifically binds hypervariable region and G-domain in cytosol prior farnesylation. Then,...
Functions are diversified by producing hierarchical structures from a single raw material. Biologically compatible milk protein of κ-casein has been employed to fabricate higher-order suprastructures. In the presence dithiothreitol and heat treatment, transforms into amyloid fibrils with distinctive morphology attributable mechanism-based fibrillar polymorphism. As elongate yield high aspect ratio during high-temperature incubation, resulting laterally associate liquid crystalline state...
Photoelectrochemical (PEC) water splitting provides an attractive route for large-scale solar energy storage, but issues surrounding the efficiency and stability of photoelectrode materials impose serious restrictions on its advancement. In order to relax one criteria, band gap, a promising strategy involves complementing conventional PEC setup with additional power sources. Here we introduce new concept: combined reverse electrodialysis (RED). RED is membrane-based generation technology...
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A new Merrifield-resin-derived glycinimine tert-butyl ester (9) was prepared and applied to the enantioselective synthesis of non-natural α-amino acids. High enantioselectivities (86 >99% ee) were accomplished by employing aldimine linker under phase-transfer alkylation conditions, using 50% aqueous CsOH in toluene/chloroform (7:3) at 0 °C presence N-(9-anthracenylmethyl)-O(9)-allylcinchonidium bromide (10 mol %).