A5100416299- Marine Sponges and Natural Products
- Marine Toxins and Detection Methods
- Microbial Natural Products and Biosynthesis
- Environmental Toxicology and Ecotoxicology
- Protist diversity and phylogeny
- Marine and coastal ecosystems
- Synthetic Organic Chemistry Methods
- Natural product bioactivities and synthesis
- Chemical synthesis and alkaloids
- Chemical Synthesis and Analysis
- Microbial Metabolism and Applications
- Nicotinic Acetylcholine Receptors Study
- Microbial Community Ecology and Physiology
- Bioactive Compounds and Antitumor Agents
- Plant biochemistry and biosynthesis
- Methane Hydrates and Related Phenomena
- Cholinesterase and Neurodegenerative Diseases
- Molecular spectroscopy and chirality
- Polyamine Metabolism and Applications
- Synthesis of Organic Compounds
- Energy and Environmental Systems
- Synthesis and Reactivity of Heterocycles
- Diverse Topics in Contemporary Research
- Consumer Perception and Purchasing Behavior
- melanin and skin pigmentation
Korea Electronics Technology Institute
2024
Korea University of Science and Technology
2009-2024
Korea Institute of Ocean Science and Technology
2016-2024
Government of the Republic of Korea
2020
Harvard University
2017
Korea Institute of Geoscience and Mineral Resources
2013
Seoul National University
2005
Chemical investigation of a marine-derived fungus, Penicillium steckii 108YD142, resulted in the discovery new tanzawaic acid derivative, Q (1), together with four known analogues, acids A (2), C (3), D (4), and K (5). The structures derivatives 1-5 were determined by detailed analysis 1D, 2D NMR LC-MS data, along chemical methods literature data analysis. These compounds significantly inhibited nitric oxide (NO) production (1) lipopolysaccharide (LPS)-induced inducible synthase (iNOS)...
Highly enantioselective synthesis of a potent metabotropic receptor ligand, (2S)-α-(hydroxymethyl)-glutamic acid (2, HMG) was accomplished by the catalytic Michael addition 2-naphthalen-1-yl-2-oxazoline-4-carboxylic tert-butyl ester (3b), using phosphazene base, BEMP, in CH2Cl2 at −60 °C presence (S)-binaphthyl quaternary ammonium salt 4.
A new α-pyrone merosesquiterpenoid possessing an angular tetracyclic carbon skeleton, ochraceopone F (1), and four known secondary metabolites, aspertetranone D (2), cycloechinulin (3), wasabidienone E (4), mactanamide (5), were isolated from the marine fungus Aspergillus flocculosus derived a sponge Stylissa sp. collected in Vietnam. The structures of Compounds 1–5 elucidated by analysis 1D 2D NMR spectra MS data. All compounds evaluated for anti-proliferation activity their suppression...
Ten new norterpene alkaloids, coscinoderines A–J (1–10), were isolated from the marine sponge Coscinoderma bakusi. Each coscinoderine contains a 1,2,5-trisubstituted pyridinium moiety bearing terpene unit at C-2 position. Their structures elucidated by analysis of NMR and HRMS data, absolute stereochemistry 4 with 2-methylbutyl group attached to nitrogen was determined comparison calculated measured ECD spectra. The isolation expands repertoire alkaloids sponges.
Three furan-containing scalarane sesterterpenoids (1⁻3) and a novel pyrrole-containing analog (4) were isolated from the sponge Scalarispongia species. Compound 3, reported in literature as synthetic derivative of furoscalarol 2, was for first time natural source. During separation performed using silica column presence methanol, 16-methoxy derivatives (5, 6) obtained unintended reaction 2. The products 3 4 artifact 5 showed moderate to high cytotoxicity against six human cancer cell lines,...
A stereocontrolled synthesis of the left halves halichondrins was reported. An intramolecular oxy-Michael reaction under basic conditions used to construct [6,6]-spiroketal in a manner. With this approach, halichondrins, homohalichondrins, and norhalichondrins were synthesized.
We describe a synthetic approach for set of fluorescent thieno[3,2-b]pyridine-5(4H)-one derivatives and their photophysical properties. These fluorophores are prepared by series reactions employing the Suzuki–Miyaura cross-coupling reaction regioselective aza-[3 + 3] cycloaddition 3-aminothiophenes with α,β-unsaturated carboxylic acids. Our findings revealed that properties chemically tunable an appropriate choice functional group on scaffold.
Three new phenazine derivatives (1–3), along with known compounds (4–7) of saphenic acid derivatives, were isolated from a deep-sea sediment-derived yeast-like fungus Cystobasidium larynigs collected the Indian Ocean. The structures (1–3) determined by analysis spectroscopic data, semi-synthesis and comparison optical rotation values. All (1–7), except for 2, showed nitric oxide (NO) production inhibitory effect against lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells...
Abstract Background and Purpose Mitochondrial dysfunction contributes to the pathogenesis maintenance of chemotherapy‐induced peripheral neuropathy (CIPN), a significant limitation cancer chemotherapy. Recently, stimulation mitophagy, pivotal process for mitochondrial homeostasis, has emerged as promising treatment strategy neurodegenerative diseases, but its therapeutic effect on CIPN not been explored. Here, we assessed mitophagy‐inducing activity...
Chemical investigation of
The chemical investigation of the marine sponge
Three new sulfated steroidal glycosides (3–5), along with known cholesterol derivatives (1,2), were isolated from the visceral extract of cone snail Conus pulicarius. The structure each compound was elucidated by nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. three compounds exhibited significant in vitro cytotoxicity (GI50 values down to 0.49 μM) against K562 human leukemia cell line.
A chemical investigation of a methanol extract Spongia sp., marine sponge collected from the Philippines, identified 12 unreported scalarane-type alkaloids—scalimides A–L (1–12)—together with two previously described scalarin derivatives. The elucidation structure scalaranes based on interpretation their NMR and HRMS data revealed that 1–12 featured β-alanine-substituted E-ring but differed each other through variations in oxidation states substitutions occurring at C16, C24, C25. Evaluation...
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A total of eight new oxygenated 4-exo-methylene sterols, 1–8, together with one artifact 9 and six known sterols 11–16, were isolated from the marine sponge Theonella swinhoei collected Bohol province in Philippines. Structures 1–8 determined 1D 2D NMR data. Among 8α-hydroxytheonellasterol (4) spontaneously underwent an allylic 1,3-hydroxyl shift to produce 15α-hydroxytheonellasterol (9) as artifact; this was rationalized by quantum mechanical calculations transition state. In addition,...
Enantioselective routes for the total synthesis of ieodomycins A & B, and three stereochemical analogues ieodomycin B <italic>via</italic> a late-stage elaboration side chain.