A5033850014- Biosensors and Analytical Detection
- Bacteriophages and microbial interactions
- Atmospheric chemistry and aerosols
- Atmospheric and Environmental Gas Dynamics
- Atmospheric Ozone and Climate
- Acoustic Wave Resonator Technologies
- Magnetic confinement fusion research
- Advanced biosensing and bioanalysis techniques
- Listeria monocytogenes in Food Safety
- Advanced Chemical Sensor Technologies
- Salmonella and Campylobacter epidemiology
- Probiotics and Fermented Foods
- T-cell and B-cell Immunology
- Psoriasis: Treatment and Pathogenesis
- Viral gastroenteritis research and epidemiology
- Food Quality and Safety Studies
- Air Quality and Health Impacts
- Superconducting Materials and Applications
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- NF-κB Signaling Pathways
- Natural product bioactivities and synthesis
- Rheumatoid Arthritis Research and Therapies
- Macrophage Migration Inhibitory Factor
- Phytoplasmas and Hemiptera pathogens
Kyungpook National University
2016-2025
Catholic University of Korea
2009-2023
Chungnam National University
2023
Seoul St. Mary's Hospital
2009-2023
National Cancer Center
2009-2022
Korea Research Institute of Chemical Technology
2010-2020
Hankuk University of Foreign Studies
2020
Yonsei University
2005-2019
Kosin University
2018-2019
National Institute of Environmental Research
2019
Recent studies of the pathogenesis rheumatoid arthritis (RA) have revealed that both synovial fibroblasts and T cells participate in perpetuation joint inflammation as dynamic partners a mutual activation feedback, via secretion cytokines chemokines stimulate each other. In this study, we investigated role IL-17, major Th1 cytokine produced by activated cells, RA fibroblasts. Transcripts IL-17R (IL-17 receptor) IL-17RB receptor B) were present fibroblast-like synoviocytes (FLS) patients....
Abstract DOT1L has emerged as an anticancer target for MLL-associated leukaemias; however, its functional role in solid tumours is largely unknown. Here we identify that cooperates with c-Myc and p300 acetyltransferase to epigenetically activate epithelial–mesenchymal transition (EMT) regulators breast cancer progression. recognizes SNAIL , ZEB1 ZEB2 promoters via interacting the c-Myc-p300 complex facilitates lysine-79 methylation acetylation towards histone H3, leading dissociation of...
Cold induces expression of a number genes that encode proteins enhance tolerance to freezing temperatures in plants. A cis-acting element responsive cold and drought, the C-repeat/dehydration-responsive (C/DRE), was identified Arabidopsis thaliana stress-inducible RD29A COR15a found other cold-inducible various C/DRE-binding factor/DRE-binding protein (CBF/DREB) is an essential component cold-acclimation response, but signaling pathways networks are mostly unknown. Here we used targeted...
To examine the regulatory role of interleukin-22 (IL-22) in expression RANKL and induction osteoclastogenesis rheumatoid arthritis (RA).Concentrations IL-22 serum synovial fluid RA patients were measured using enzyme-linked immunosorbent assay. fibroblasts treated with recombinant human (rhIL-22), messenger RNA (mRNA) protein was real-time polymerase chain reaction, Western blotting, intracellular immunostaining. Human monocytes cocultured IL-22-prestimulated macrophage colony-stimulating...
High-frequency in situ measurements at Gosan (Jeju Island, Korea) during November 2007 to December 2008 have been combined with interspecies correlation analysis estimate national emissions of halogenated compounds (HCs) East Asia, including the chlorofluorocarbons (CFCs), halons, hydrochlorofluorocarbons (HCFCs), hydrofluorocarbons (HFCs), perfluorocarbons (PFCs), sulfur hexafluoride (SF6), and other chlorinated brominated compounds. Our results suggest that overall China is dominant...
Abstract. We report a 40-year history of SF6 atmospheric mole fractions measured at the Advanced Global Atmospheric Gases Experiment (AGAGE) monitoring sites, combined with archived air samples, to determine emission estimates from 1978 2018. Previously we reported global rate 7.3±0.6 Gg yr−1 in 2008 and over past decade emissions have continued increase by about 24 % 9.04±0.35 show that changing patterns consumption developed (Kyoto Protocol Annex-1) developing countries (non-Annex-1) rapid...
This study aimed to isolate lactic acid bacteria (LAB) from a traditional Ethiopian fermented product, Tella, and evaluate their functional properties. Of forty-three isolates, seven LAB were screened identified as Pediococcus pentosaceus, Latilactobacillus curvatus, Leuconostoc mesenteroides, Lactiplantibacillus plantarum species. The isolates tested for alcohol tolerance, bile resistance, auto-aggregation, co-aggregation, hydrophobicity, antibacterial activity, antibiotic susceptibility....
Stromal cell-derived factor 1 (SDF-1) is a potent chemoattractant for memory T cells in inflamed rheumatoid arthritis (RA) synovium. This study was undertaken to investigate the effect of interleukin-17 (IL-17) and CD40-CD40L interaction on SDF-1 production RA fibroblast-like synoviocytes (FLS).Synovial fluid (SF) serum levels patients were measured by enzyme-linked immunosorbent assay (ELISA). The produced cultured FLS evaluated real-time polymerase chain reaction ELISA after treated with...
High‐frequency in‐situ measurements of a wide range halogenated compounds including chlorofluorocarbons (CFCs), halons, hydrochlorofluorocarbons (HCFCs), hydrofluorocarbons (HFCs), perfluorinated (PFCs), sulfur hexafluoride (SF 6 ), and other chlorinated brominated have been made at Gosan (Jeju Island, Korea). Regional emissions HCFC‐22 (CHClF 2 ) calculated from inverse modeling were combined with interspecies correlation methods to estimate national for China, major emitter industrial...
Abstract Dichloromethane (CH 2 Cl ) and perchloroethylene (C 4 are chlorinated very short lived substances (Cl‐VSLS) with anthropogenic sources. Recent studies highlight the increasing influence of such compounds, particularly CH , on stratospheric chlorine budget therefore ozone depletion. Here, a multiyear global‐scale synthesis inversion was performed to optimize (2006–2017) C (2007–2017) emissions. The approach combines long‐term surface observations from global monitoring networks,...
Chronic autoimmune inflammation, which is commonly observed in rheumatoid arthritis (RA), disrupts the delicate balance between bone resorption and formation causing thedestruction of joints. We undertook this study to verify effects natural grape-seed proanthocyanidin extract (GSPE), an antioxidant, on chronic inflammation destruction. GSPE administration ameliorated arthritic symptoms collagen-induced (CIA), are representative cartilage treatment reduced tartrate-resistant acid phosphatase...
Abstract The green tea polyphenol epigallocatechin-3-gallate is a potent antioxidant. Here, we describe the effects of on T cell differentiation and osteoclast in an animal model arthritis. Mice with collagen-induced arthritis were injected intraperitoneally epigallocatechin-3-gallate, 3 times/wk after primary immunization. Surface markers helper 17 cells regulatory analyzed by flow cytometry. Flow cytometry, Western blotting, enzyme-linked immunosorbent assays used to evaluate effect...