A5009470616- Cytokine Signaling Pathways and Interactions
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Psoriasis: Treatment and Pathogenesis
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Autoimmune and Inflammatory Disorders Research
- Cell Adhesion Molecules Research
- Systemic Sclerosis and Related Diseases
- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- Immunotherapy and Immune Responses
- Inflammatory mediators and NSAID effects
- Pharmacological Effects of Natural Compounds
- Macrophage Migration Inhibitory Factor
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Signaling Pathways in Disease
- Immunodeficiency and Autoimmune Disorders
- Atherosclerosis and Cardiovascular Diseases
- IgG4-Related and Inflammatory Diseases
- Natural product bioactivities and synthesis
Catholic University of Korea
2012-2024
Bucheon St. Mary's Hospital
2013-2024
Uijeongbu St. Mary's Hospital
2019
Seoul St. Mary's Hospital
1996-2019
University of Washington
2005
Catholic Medical Center
2000
St. Mary’s Hospital
2000
St Mary's Hospital
1997-1999
Abstract Circulating autoantibodies and immune complex deposition are pathological hallmarks of systemic lupus erythematosus (SLE). B cell differentiation into plasma cells (PCs) some T subsets that function as helpers can be therapeutic targets SLE. Mechanistic target rapamycin (mTOR) signaling is implicated in the formation germinal centers (GCs). We assessed effect metformin, which inhibits mTOR, on development autoimmunity using Roquinsan/san mice. Oral administration metformin inhibited...
Objective The NLRP 3 inflammasome is closely linked to the pathophysiology of a wide range inflammatory diseases. This study was undertaken identify small molecules that directly bind in order develop pharmacologic interventions for 3‐related Methods A structure‐based virtual screening analysis performed with ~62,800 compounds select efficient inhibitors. production caspase 1‐p10 and interleukin‐1β ( IL ‐1β) measured by immunoblotting enzyme‐linked immunosorbent assay examine activation. Two...
The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It been suggested IL-33/ST2 involved the pathogenesis of rheumatoid arthritis (RA), because IL-33 its receptor have specifically mapped to RA synovium. aim this study was determine levels sST2 sera synovial fluids patients with RA. serum level significantly higher (294.9 ± 464.0 pg/mL) than healthy controls (96.0 236.9 pg/mL, P =...
Abstract IL-23, a clinically novel cytokine, targets CD4+ T cells. Recent IL-1Ra−/− mouse studies have demonstrated that IL-23 indirectly stimulates the differentiation of osteoclast precursors by enhancing IL-17 release from IL-17, in turn, osteoclastogenesis precursor In this study, we found up-regulates receptor activator NF-κB ligand expression cells, and thus contributes to osteoclastogenesis. This indirect pathway is mediated STAT3. We also can influence positively under special...
Objective: Systemic sclerosis (SSc) is a progressive fibrotic disease that affects the skin and internal organs. Despite evidence implicating increased interleukin-17 (IL-17) activity in SSc, role of IL-17 SSc remains uncertain. The purpose this study was to investigate whether plays pathophysiological two different murine models SSc. Methods: Bleomycin (BLM)-induced fibrosis chronic graft-versus-host (cGVHD) were used. Histological analysis performed using Masson's trichrome...
Interleukin (IL)-27 is a novel cytokine of the IL-6/IL-12 family that has been reported to be involved in pathogenesis autoimmune diseases and pivotal role as both pro- anti-inflammatory cytokine. We investigated vivo effects IL-27 on arthritis severity murine collagen-induced (CIA) model its mechanism action regarding control regulatory T (Tregs) IL-17-producing helper 17 (Th17) cells. IL-27-Fc-treated CIA mice showed lower arthritis. IL-17 expression spleens was significantly decreased...
Abstract Rheumatoid arthritis (RA) is a systemic inflammatory disease that mainly affects the synovial joints. Although involvement of fibroblast growth factor (FGF) signaling pathway has been suggested as an important modulator in RA development, no clear evidence provided. In this study, we found fluid basic FGF (bFGF) concentration was significantly higher than osteoarthritis (OA) patients. bFGF stimulates proliferation and migration human fibroblast-like synoviocytes (FLSs) by activation...
Mesenchymal stem cells (MSCs) can protect against cartilage breakdown in osteoarthritis (OA) via their immunomodulatory capacities. However, the optimization strategy for using MSCs remains challenging. This study's objective was to identify vivo effects of metformin-stimulated adipose tissue-derived human (Ad-hMSCs) OA. An animal model OA established by intra-articular injection monosodium iodoacetate into rats. rats were divided a control group and two therapy groups (treated with Ad-hMSCs...
Objective To determine the presence of specific immune recognition type II collagen (CII) and its immunodominant epitope CII (255–274) in patients with rheumatoid arthritis (RA). Methods T cell proliferative responses to bovine a synthetic peptide encompassing peripheral blood mononuclear cells (PBMC) synovial fluid (SFMC) from RA patients, PBMC osteoarthritis (OA) healthy controls were assayed by mixed lymphocyte culture. Results The stimulation index (SI) number positive (SI ≥2) higher (n...
The objectives were to investigate the in vivo effects of treatment with rebamipide on pain severity and cartilage degeneration an experimental model rat osteoarthritis (OA) explore its mode action.OA was induced rats by intra-articular injection monosodium iodoacetate (MIA). Oral administration initiated day MIA injection, 3 or 7 days after. Limb nociception assessed measuring paw withdrawal latency threshold. We analyzed samples macroscopically histomorphologically, used...
White fat cells secrete adipokines that induce inflammation and obesity has been reported to be characterized by high serum levels of inflammatory cytokines such as IL-6 TNF-α. Rheumatoid arthritis (RA) is a prototype arthritis, but the relationship between RA controversial. We made an obese model: collagen-induced (CIA). C57BL/6 mice were fed 60-kcal diet (HFD) from age 4 weeks they immunized twice with type II collagen (CII). After immunization, CIA showed higher index scores histology...
Chronic autoimmune inflammation, which is commonly observed in rheumatoid arthritis (RA), disrupts the delicate balance between bone resorption and formation causing thedestruction of joints. We undertook this study to verify effects natural grape-seed proanthocyanidin extract (GSPE), an antioxidant, on chronic inflammation destruction. GSPE administration ameliorated arthritic symptoms collagen-induced (CIA), are representative cartilage treatment reduced tartrate-resistant acid phosphatase...
Increases in oxidative stress are thought to be associated with the development of osteoarthritis (OA). Eupatilin, one major compounds present artemisia species, was shown have both anti-oxidative and anti-inflammatory properties. Here, we investigated vivo effects eupatilin on pain severity cartilage degradation an experimental rat model OA, along mechanisms action underlying these effects. Experimental OA induced via intra-articular injection monosodium iodoacetate (MIA), oral...
Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disease characterized by upregulation of cell death osteoclastogenesis. Necrostatin (NST)-1s chemical inhibitor receptor-interacting serine/threonine-protein kinase (RIPK)1, which plays role in necroptosis. We investigated whether NST-1s decreases responses mouse model collagen-induced (CIA). decreased the progression CIA synovial expression proinflammatory cytokines. Moreover, treatment necroptosis mediators such as RIPK1,...
Abstract Objective Although oral tolerance is a well‐known phenomenon, the role of dendritic cells (DCs) not well characterized. This study was conducted to better understand differential played by each Peyer's patch DC subset in induction type II collagen (CII) murine collagen‐induced arthritis (CIA). Methods CII fed 6 times DBA/1 mice beginning 2 weeks before immunization, and effect on assessed. We compared proportion CD11c+,CD11b+ DCs CD11c+,CD8α+ patches CII‐fed tolerized phosphate...
Rebamipide, a gastroprotective agent, has the ability to scavenge reactive oxygen radicals. Increased oxidative stress is implicated in pathogenesis of rheumatoid arthritis (RA). We undertook this study investigate impact rebamipide on development and pathophysiologic mechanisms by which attenuates severity murine model RA.Collagen-induced (CIA) was induced DBA/1J mice. Anti-type II collagen antibody titers interleukin-17 (IL-17) levels were determined using enzyme-linked immunosorbent...
Objective Dual‐specificity phosphatase 5 (DUSP‐5) is a that specifically dephosphorylates both phosphoserine and phosphotyrosine residues of MAPK. The dysregulated activation MAPK contributes to the pathogenesis rheumatoid arthritis. This study was undertaken investigate therapeutic potential DUSP‐5 in preventing development autoimmune arthritis an animal model. Methods Autoimmune induced DBA/1J mice by immunization with type II collagen (CII). Eight days after CII immunization, were...
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is an important transcription that plays a pivotal role in cellular defense against oxidative injury. Nrf2 signaling involved attenuating autoimmune disorders such as rheumatoid arthritis (RA). B cells play several roles the pathogenesis of RA, autoantibody production, antigen presentation, and T-cell activation. We investigated anti-arthritic mechanisms sulforaphane, activator Nrf2, terms its effect on cells. To investigate sulforaphane...
Abstract Objective To determine the antiangiogenic effect of cyclosporin A (CSA) in rheumatoid arthritis (RA). Methods We investigated CSA on production vascular endothelial growth factor (VEGF) by synovial fibroblasts. Fibroblast‐like synoviocytes (FLS) were prepared from tissues RA patients, and cultured presence CSA. The VEGF FLS was measured culture supernatants enzyme‐linked immunosorbent assay. messenger RNA (mRNA) expression activator protein 1 (AP‐1) binding activity for...