Frequency-domain analyses of R-R intervals are used widely to estimate levels autonomic neural traffic the human heart. Because respiration modulates activity, we determined for nine healthy subjects influence breathing frequency and tidal volume on interval power spectra (fast-Fourier transform method). We also surveyed published literature determine current practices in this burgeoning field scientific inquiry. Supine breathed at rates 6, 7.5, 10, 15, 17.1, 20, 24 breaths/min with nominal...

Objective The NLRP 3 inflammasome is closely linked to the pathophysiology of a wide range inflammatory diseases. This study was undertaken identify small molecules that directly bind in order develop pharmacologic interventions for 3‐related Methods A structure‐based virtual screening analysis performed with ~62,800 compounds select efficient inhibitors. production caspase 1‐p10 and interleukin‐1β ( IL ‐1β) measured by immunoblotting enzyme‐linked immunosorbent assay examine activation. Two...

Nuclear factor of activated T-cells 5 (NFAT5), an osmo-sensitive transcription factor, can be by isotonic stimuli, such as infection. It remains unclear, however, whether NFAT5 is required for damage-associated molecular pattern-triggered (DAMP-triggered) inflammation and immunity. Here, we found that several DAMPs increased expression in macrophages. In particular, serum amyloid A (SAA), primarily generated the liver, substantially upregulated activity through TLR2/4-JNK signalling pathway....

We investigated the clinical and laboratory characteristics of pregnancies with systemic lupus erythematosus (SLE) identified flare predictors during pregnancy. Additionally, we examined activity pregnancy outcomes in SLE patients who continued, discontinued or underwent no hydroxychloroquine (HCQ) treatment retrospectively analyzed 179 128 at Seoul St. Mary's Hospital, Korea, between 1998 2012 then assessed profiles maternal fetal outcomes. Overall, 90.5% resulted a successful delivery were...

Abstract Lipid mediators are crucial for the pathogenesis of rheumatoid arthritis (RA); however, global analyses have not been undertaken to systematically define lipidome underlying dynamics disease evolution, activation, and resolution. Here, we performed untargeted lipidomics analysis synovial fluid serum from RA patients at different activities clinical phases (preclinical phase active sustained remission). We found that profile in joint was severely perturbed this correlated with extent...

Abstract Background We aimed to investigate the gut microbiota of patients with established rheumatoid arthritis (RA) who have been managed disease-modifying anti-rheumatic drugs (DMARDs) for a long time. focused on factors that might affect composition microbiota. Furthermore, we investigated whether predicts future clinical responses conventional synthetic DMARDs (csDMARDs) in an insufficient response initial therapy. Methods recruited 94 RA and 30 healthy participants. Fecal microbiome...

The pathophysiology of exocrine dysfunction observed in Sjögren's syndrome (SS) is not fully understood. purpose this study was to investigate whether autoantibodies against human AQP5 are present the sera SS patients. Frozen sections mouse submandibular salivary glands, CHO cells over-expressing a AQP5–GFP fusion protein or GFP, and MDCK were used indirect immunofluorescence assay detect anti-AQP5 from patients with primary SS. lysates HEK-293 GFP for immunoprecipitation. Serum IgG but...

'Invasive pannus' is a pathological hallmark of rheumatoid arthritis (RA). This study aimed to investigate secretome profile synovial fibroblasts patients with RA (RA-FLSs), major cell type comprising the invasive pannus.Secreted proteins from RA-FLSs were first identified using liquid chromatography-tandem mass spectrometry analysis. Ultrasonography was performed for affected joints define synovitis severity at time arthrocentesis. Expression levels myosin heavy chain 9 (MYH9) in and...

We investigated obstetric outcomes and comorbidities during pregnancy in females with preexisting lupus nephritis (LN) identified predictors for renal flare. In cases of flare pregnancy, we assessed the long-term post-delivery outcome. performed a retrospective analysis 183 systemic erythematosus (SLE) pregnancies including blood chemistry, urinalysis, urinary protein, disease activity recorded at prepregnancy, one month, six months, year post-delivery. Pregnancies LN had greater frequency...

Most previous research investigating osteoporosis in rheumatoid arthritis (RA) has focused on female patients and there is a lack of data regarding clinical characteristics male with RA. The aim this study was to compare the frequency between RA healthy patients, identify risk factors for low bone mineral density (BMD) We conducted retrospective, cross-sectional including 76 South Korean aged over 50 years age-matched individuals. BMD measured at lumbar spine (L1-4) left hip (femoral neck...

Angiogenesis and synoviocyte hyperplasia, called 'pannus,' are pathologic hallmarks of rheumatoid arthritis (RA). To determine the clinical significance angiogenic cytokines in RA, levels pro-angiogenic cytokines, including VEGF, placenta growth factor (PlGF), IL-6, were measured synovial fluid (SF, n = 54) sera RA patients (n 157) using ELISA. Patients 103) with disease activity score 28 (DAS28) > 3.2, which indicates moderate to high activity, underwent follow-up blood sampling at 6 months...

Background/Aims To determine the prevalence of autonomic dysfunction among Korean patients with primary Sjogren's syndrome (pSS) and its associations clinical features pSS. Methods We analyzed 154 participants from Initiative Syndrome (KISS) as a prospective pSS cohort age- sex-matched healthy controls. A standardized 5-minute, supine, resting heart rate variability (HRV) test was performed, defined standard deviation normal-to-normal RR intervals (SDNN) < 30 ms in 50 years old SDNN 20 ≥...

This study sought to investigate the associations between personality traits and medication adherence identify predictors of good in rheumatoid arthritis (RA) patients.A total 207 RA patients using disease-modifying anti-rheumatic drugs were invited for an interview questionnaire study. Medication was measured Compliance Questionnaire Rheumatology (CQR). Personality analyzed with five-factor model Korean version Big Five Inventory 10. Psychological factors assessed Patient Health...

Abstract Aims To investigate demographic, clinical, laboratory, and immunological characteristics of patients with systemic lupus erythematosus (SLE) in southeastern areas South Korea, to perform survival analysis. Methods We retrospectively evaluated 413 SLE diagnosed 3 tertiary rheumatology centers Korea from 1992 2016 by reviewing their medical charts. All fulfilled the 1997 revised American College Rheumatology classification criteria for SLE. Results Most were women (92%), mean...

Stromal vascular fraction (SVF) has recently emerged as a potential therapeutic modality, due to its multipotent cellular components in tissue regeneration. Systemic sclerosis (SSc) is progressive autoimmune disease that results hand disability by skin fibrosis and microangiopathies. We performed an open-label study investigate the efficacy safety of SVF injection SSc patients (Clinical Trial number: NCT03060551).We gathered 20 with disability, planning for 24-week follow-up period. was...

To assess the effects of biological and targeted synthetic disease-modifying antirheumatic drugs (DMARDs) on lipid profiles in patients with moderate-to-severe rheumatoid arthritis (RA).This retrospective single-center observational study included RA taking a tumor necrosis factor-α inhibitor (TNFi), abatacept, tocilizumab, or Janus kinase (JAKi) for at least 6 months. Changes profile were assessed months after start treatment, associations between changes clinical efficacy, concomitant...

Objective Seronegative rheumatoid arthritis (RA) is defined as RA without circulating autoantibodies such factor and anti-citrullinated protein antibodies; thus, early diagnosis of seronegative can be challenging. Here, we aimed to identify diagnostic biomarkers for by performing lipidomic analyses sera urine samples from patients with RA. Methods We performed untargeted analysis 111 patients, 45 osteoarthritis (OA) 25 healthy controls (HC). These were divided into a discovery cohort (n =...

This study was performed to investigate the clinical characteristics of lupus cystitis and determine risk factors outcomes in patients with systemic erythematosus (SLE). We retrospectively reviewed 1064 at Seoul St. Mary's Hospital Seoul, Korea, from 1998 2013. Twenty-four had cystitis. Lupus defined as unexplained ureteritis and/or detected by imaging studies, cystoscopy, or bladder histopathology without urinary microorganisms stones. Three-fourths concurrent mesenteric vasculitis (LMV)....

Rheumatoid arthritis (RA) is closely associated with the oral and gut microbiomes. Fungal cell wall components initiate inflammatory in mouse models. However, little known regarding role of fungal community pathogenesis RA. To evaluate association between RA microbiome, investigations bacterial communities patients are necessary. Therefore, we investigated compositions associations fecal 30 healthy controls 99 The relative abundances Bifidobacterium Blautia decreased, whereas abundance...

Objective The relationship between mechanical stress and radiographic progression in rheumatoid arthritis (RA) is unclear. assumption that greater the dominant hand. Therefore, aim of present study was to compare presence erosions joint space narrowing (JSN) non-dominant Methods Data from 194 patients recently diagnosed with seropositive RA, hand radiographs taken at time diagnosis 2-year follow-up, were analyzed retrospectively. Radiographs scored using van der Heijde-modified Sharp Score...