A5049158733- Spondyloarthritis Studies and Treatments
- Bone and Joint Diseases
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Psoriasis: Treatment and Pathogenesis
- HIV-related health complications and treatments
- HIV Research and Treatment
- Systemic Sclerosis and Related Diseases
- Bone health and osteoporosis research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Musculoskeletal synovial abnormalities and treatments
- Orthopedic Surgery and Rehabilitation
- Bone Metabolism and Diseases
- Inflammasome and immune disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Gout, Hyperuricemia, Uric Acid
- Inflammatory Myopathies and Dermatomyositis
- Pulmonary Hypertension Research and Treatments
- Hip disorders and treatments
- Vasculitis and related conditions
- Salivary Gland Disorders and Functions
- Nutrition and Health in Aging
- Hepatitis C virus research
- Spine and Intervertebral Disc Pathology
Catholic University of Korea
2015-2024
Incheon St. Mary's Hospital
2015-2024
Johns Hopkins University
2024
Johns Hopkins Medicine
2024
Incheon Catholic University
2020
Center for Rheumatology
2016
Seoul St. Mary's Hospital
2007-2015
St. Paul's Hospital
2014
Chungbuk National University Hospital
2011-2012
Chungbuk National University
2010-2012
Interleukin (IL)-21 is a cytokine that controls the functional activity of effector T helper cells and differentiation Th17 cells, promotes B-cell differentiation. To test whether IL-21 participates in pathogenesis primary Sjögren's syndrome (SS), serum level was measured expression labial salivary glands (LSG) examined. Serum levels 40 SS, rheumatoid arthritis (RA), 38 systemic lupus erythematosus (SLE) patients 20 healthy were measured. SS assessed for correlations with laboratory data,...
Objective. Synovial fluid (SF) is one of the most important materials that reflect pathophysiological process arthritis. A metabolomic and lipidomic study SF was performed with aim identifying tentative diagnostic markers or therapeutic candidates for rheumatoid arthritis (RA). Methods. aspirated from 10 patients RA osteoarthritis (OA). OA were collected analyzed by ultraperformance liquid chromatography quadruple time-of-flight mass spectrometry. Associations among clinical variables,...
Objectives. To determine the longitudinal effects of TNF inhibitors on BMD and radiographic progression in patients with AS to assess independent factors associated increased lumbar spine.
We aimed to investigate the association of serum UA level with muscle strength assessed by handgrip (HGS) in a large Korean adult population. Cross-sectional data were obtained from seventh Korea National Health and Nutrition Examination Survey (KNHANES) 2016. The KNHANES 2016 study included 8150 subjects, whom 4230 subjects analyzed this study. between HGS was investigated adjustment for confounding factors. Serum divided into sex-specific tertiles After potential factors, significantly...
The aim of this study was to determine whether the incidence cancer has increased among patients with systemic sclerosis (SSc) in Korea.The subjects consisted 112 who had been consecutively evaluated for at least 6 months between 1990 and 2007. We retrospectively reviewed their medical records, investigated rate compared it that Korea National Cancer Centre database.Nine out developed (four males five females). average age diagnosis 56.4 years mean disease duration 8.9 years. standardized...
The effects of several antihypertensive drugs on bone mineral density (BMD) and micro-architectural changes in ovariectomized (OVX) mice were investigated. Eight-week-old female C57/BL6 used for this study. Three days after ovariectomy, treated intraperitoneally with nifedipine (15 mg/kg), telmisartan (5 enalapril (20 propranolol (1 mg/kg) or hydrochlorothiazide (12.5 35 consecutive days. Uterine atrophy all was confirmed to evaluate estrogen deficiency state. BMD analyses performed tibial...
Objective. To examine factors related to a low trabecular bone score (TBS) and the association between TBS vertebral fractures in patients with ankylosing spondylitis (AS). Methods. One hundred (all male, aged < 50 yrs) who fulfilled modified New York criteria for classification of AS were enrolled. The mineral density (BMD) assessed using dual-energy X-ray absorptiometry. Clinical variables, inflammatory markers, presence also assessed. Sacroiliitis grade spinal structural damage...
This study aimed to investigate whether the presence of low bone mineral density (BMD) in patients with axial spondyloarthritis (axSpA) predicts formation new syndesmophytes over 2 years. One hundred and nineteen fulfilling imaging arm Assessment SpondyloArthritis International Society axSpA criteria were enrolled. All under 50 years age. The modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) was assessed by two trained readers blinded patients' data. BMD (lumbar spine, femoral neck...
Pulmonary arterial hypertension (PAH) is a major cause of mortality in connective tissue disease (CTD). The survival rates and mortality-predictive factors nationwide registry Korean patients with CTD-PH measured by echocardiography were determined.Patients enrolled between April 2008 December 2012. Hemodynamic parameters clinical data (WHO-functional class [FC], organ involvement, laboratory tests treatment agents) recorded. Survival calculated using the Kaplan-Meier method....
To compare the trabecular bone score (TBS) between patients with axial spondyloarthritis (axSpA) and matched normal controls identify risk factors associated a low TBS.TBS BMD were assessed in two groups (axSpA control) using DXA. Osteoporosis inflammatory markers also assessed. Disease activity radiographic progression sacroiliac joint spine evaluated axSpA group. Multivariate linear regression analysis was performed to TBS.In group, 248 subjects enrolled; an equal number of age-...
Background/Aims We investigated whether transthoracic echocardiography-suspected pulmonary hypertension (PH) affects survival in systemic lupus erythematosus (SLE) patients and examined factors associated with PH occurrence survival. Methods This retrospective single-center study included 154 Korean SLE fulfilling the American College of Rheumatology criteria (January 1995 to June 2013). Student t test, Mann-Whitney U Kaplan-Meier curves, log-rank tests were used for comparisons. Results A...
Background: Systemic lupus erythematosus (SLE) is a rare autoimmune disease for which population-based survey on the prevalence of in South Korea has not yet been conducted. Our goal was to estimate nationwide SLE.Methods: The International Classification Diseases, Tenth Revision (ICD-10) code SLE diagnosis—M32—was tentatively given when patients were suspected have before 2009. As such, positive predictive value (PPV) M32 shown medical bills reflecting true uncertain. We attempted using...
Abstract Introduction Ankylosing spondylitis (AS) is associated with an increased incidence of vertebral fractures (VFs); however the actual and predictors morphometric VFs are unknown. The present study examined new in a large AS cohort. Methods In total, 298 patients who fulfilled modified New York criteria were enrolled spinal radiographs evaluated biennially. Clinical laboratory data radiographic progression assessed according to Bath Disease Activity Index, erythrocyte sedimentation...
To compare trabecular bone scores (TBS) between axial SpA (axSpA) patients with and without vertebral fractures investigate associations TBS fractures.Two hundred fifty-five fulfilling the imaging arm of Assessment SpondyloArthritis International Society axSpA criteria were enrolled. BMD assessed using dual-energy X-ray absorptiometry. Vertebral fracture thoracic lumbar spine was defined according to Genant criteria. Osteoporosis risk factors, inflammatory markers, DAS spinal structural...
Hyaluronic acid in pleural tissues from patients with mesothelioma, carcinoma, and asbestosis of the lung was quantified by using specific glycosaminoglycan-degrading enzymes. In all cases quantity hyaluronic mg/g dry tissue at least 0.10 mg, whereas carcinomatous pleura contained 0.02 to 0.03 tissue.
Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes mild to severe joint inflammation. During RA pathogenesis, fibroblast-like synoviocytes (FLS) acquire tumor-like phenotype and mediate cartilage destruction both directly indirectly by producing proinflammatory cytokines matrix metalloproteinases (MMPs). KLF4, member of the KLF family, plays significant roles in cell survival, proliferation, differentiation. A recent study reported increased expression KLF4 synovial tissue...