Won Chul Lee

ORCID: 0000-0001-8479-0836
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About
Contact & Profiles
Research Areas
  • Advanced MEMS and NEMS Technologies
  • Mechanical and Optical Resonators
  • Graphene research and applications
  • 2D Materials and Applications
  • Force Microscopy Techniques and Applications
  • Advanced Electron Microscopy Techniques and Applications
  • Microfluidic and Bio-sensing Technologies
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Gold and Silver Nanoparticles Synthesis and Applications
  • nanoparticles nucleation surface interactions
  • Nutrition, Health and Food Behavior
  • Advanced Sensor and Energy Harvesting Materials
  • Microfluidic and Capillary Electrophoresis Applications
  • Genetic factors in colorectal cancer
  • Piezoelectric Actuators and Control
  • Biosensors and Analytical Detection
  • Sensor Technology and Measurement Systems
  • Colorectal Cancer Screening and Detection
  • Health and Wellbeing Research
  • Nanopore and Nanochannel Transport Studies
  • Material Dynamics and Properties
  • Laser-Ablation Synthesis of Nanoparticles
  • Pickering emulsions and particle stabilization
  • Near-Field Optical Microscopy
  • Nutritional Studies and Diet

Hanyang University
2016-2025

Genome Insight (South Korea)
2023

Korea Institute of Materials Science
2020-2022

Catholic University of Korea
2006-2019

The University of Tokyo
2012-2017

Japan Science and Technology Agency
2012-2017

Yonsei University
2002-2015

Korea Electronics Technology Institute
2015

University of California, Berkeley
1996-2013

Korea Advanced Institute of Science and Technology
2003-2012

Watching early stage nucleation In classic theory, a metastable disordered dense liquid or amorphous solid cluster spontaneously and irreversibly transforms into crystalline nucleus. Jeon et al. observed the formation of gold crystals on graphene substrate through reduction precursor using an electron beam. Rather than view, they instead pathway that involves dynamic reversible fluctuations developing nuclei between states. The lifetime in state decreases with increasing size, at...

10.1126/science.aaz7555 article EN Science 2021-01-28

A wearable surface-enhanced Raman scattering (SERS) sensor has been developed as a patch type to utilize molecular sweat sensor. Here, the SERS is designed comprise sweat-absorbing layer, which an interface human skin, active and dermal protecting layer that prevents damage contaminations. silk fibroin protein film (SFF) basement absorbs aqueous solutions filtrates molecules larger than nanopores created in β-sheet matrix of SFF. On SFF plasmonic silver nanowire (AgNW) formed enhance signal...

10.1021/acsami.0c18892 article EN ACS Applied Materials & Interfaces 2021-01-06

Direct imaging of nanoparticle solutions by liquid phase transmission electron microscopy has enabled unique in situ studies motion and growth. In the present work, we report on real-time formation two-dimensional arrays very low diffusive limit, where nanoparticles are mainly driven capillary forces solvent fluctuations. We find that superlattice appears to be segregated into multiple regimes. Initially, front drags nanoparticles, condensing them an amorphous agglomerate. Subsequently,...

10.1021/nn203837m article EN ACS Nano 2012-02-23

Nonclassical features of crystallization in solution have been recently identified both experimentally and theoretically. In particular, an amorphous-phase-mediated pathway is found various systems as important route, different from the classical nucleation growth model. Here, we utilize high-resolution situ transmission electron microscopy with graphene liquid cells to study formation Ni nanocrystals. An amorphous phase precipitated initial stage reaction. Within particles, crystalline...

10.1021/jacs.8b11972 article EN Journal of the American Chemical Society 2019-01-04

The rapid detection of bacterial metabolites responsible for cell communication is important the early diagnosis infection and treatment with appropriate antibiotics. Surface-enhanced Raman spectroscopy (SERS) has provided amplified molecular fingerprints, serving as one most promising nondestructive label-free direct methods. However, analysis complex cultures using conventional SERS approach difficult. Here, we design a new paper-based 3D substrate establish facile one-pot Au...

10.1016/j.snb.2022.131504 article EN cc-by-nc-nd Sensors and Actuators B Chemical 2022-01-31

Unit-cell-thick MoS2 is a promising electrocatalyst for the hydrogen evolution reaction (HER) owing to its tunable catalytic activity, which determined based on energetics and molecular interactions of different types HER active sites. Kinetic responses sites, including onset, diffusion electrolyte H2 bubbles, continuation these processes, are important factors affecting activity . Investigating requires direct real-time analysis occurring spatially independent Herein, surface observed in...

10.1002/adma.202206066 article EN Advanced Materials 2022-09-19

Obesity has been investigated as a risk factor for various malignancies, including colon cancer. A case-control study was conducted on patients in three colonoscopy practices New York City to determine possible factors colorectal adenomatous polyps, known precursor lesion most cases of Among 301 case subjects with incident polyps (174 men and 127 women) 506 control (223 283 women), an increased observed increasing body mass index women (odds ratio 2.1, 95% confidence interval 1.1–4.0;...

10.1093/jnci/83.5.359 article EN JNCI Journal of the National Cancer Institute 1991-03-06

Background. Radiation, including radiation therapy (RT) for a variety of conditions, is known to be lung carcinogen. Methods. Data from the Surveillance, Epidemiology, and End Results program National Cancer Institute 1973-1986 were utilized investigate whether RT breast cancer affects risk subsequent cancer. The relative was calculated by comparing incidence rate in patients with irradiated that those nonirradiated Results. It found overall increased women who underwent irradiation compared...

10.1002/1097-0142(19930515)71:10<3054::aid-cncr2820711027>3.0.co;2-n article EN Cancer 1993-05-15

Colloidal nanocrystals inherently undergo structural changes during chemical reactions. The robust structure-property relationships, originating from their nanoscale dimensions, underscore the significance of comprehending dynamic behavior in reactive media. Moreover, complexity and heterogeneity inherent atomic structures require tracking transitions individual at three-dimensional (3D) resolution. In this study, we introduce method time-resolved Brownian tomography to investigate temporal...

10.1038/s41467-025-56476-8 article EN cc-by-nc-nd Nature Communications 2025-01-29

Transmission electron microscopy (TEM) is a crucial analysis method in materials science and structural biology, as it offers high spatiotemporal resolution for characterization reveals structure-property relationships dynamics at atomic molecular levels. Despite technical advancements EM, the nature of beam makes EM imaging inherently detrimental to even low-dose applications. We introduce SHINE, Self-supervised High-throughput Image denoising Neural network Electron microscopy,...

10.1126/sciadv.ads5552 article EN Science Advances 2025-04-02

The possible association of colorectal adenomatous polyps, a precursor lesion for cancer, with cigarette smoking, alcohol consumption, and coffee caffeine consumption was investigated in case-control study. Between April 1986 March 1988, 271 cases patients pathologically confirmed incident polyps 457 control subjects were collected from three colonoscopy practices New York City. Information on exposure obtained by structured interviews. After adjustment age, statistically significant odds...

10.1016/1047-2797(93)90025-y article EN cc-by-nc-nd Annals of Epidemiology 1993-05-01

Drying a colloidal solution of nanoparticles is versatile method to construct self-assembled structures nanoparticles. However, mechanistic understanding has mostly relied on empirical knowledge obtained from the final self-assembly as relevant processes during solvent drying are likely kinetic and far equilibrium. Here, we present in situ TEM studies nanoparticle under various conditions, including concentrations initial types substrates. The capability tracking trajectories individual...

10.1021/acs.jpclett.6b02859 article EN The Journal of Physical Chemistry Letters 2017-01-17

A microfluidics-based method for the 3D fabrication of anisotropic particles is reported. The uses a vertical microchannel where tunable light patterns solidify photocurable resins stacking multiple layers resins, thus enabling an application stereolithography concepts to conventional flow lithography. Multilayered, tapered, and angular compartmental microparticles are demonstrated.

10.1002/smll.201502968 article EN Small 2015-11-09

Crystal structures determine material properties, suggesting that crystal phase transformations have the potential for application in a variety of systems and devices. Phase transitions are more likely to occur smaller crystals; however, quantum-sized semiconductor nanocrystals, microscopic mechanisms by which not well understood. Herein, transformation 2D CdSe quantum nanosheets caused off-stoichiometry is revealed, progress directly observed situ transmission electron microscopy. The...

10.1002/advs.202205690 article EN cc-by Advanced Science 2023-01-13

The aim of this study was to analyze the prevalence and clinical characteristic metabolic syndrome adults, over 40 years old, living in Korea.This carried out for 2 years, 2003-2004, on total 5,330 individuals (2,197 men 3,133 women) selected by stratified random cluster sampling among adults old. Metabolic defined based both NCEP-ATP III criteria Modified ATP applying WHO-APR (Asian Pacific Region)'s abdominal obesity (waist circumference > 90 cm men, 80 instead criteria.Using criteria,...

10.3904/kjim.2005.20.4.310 article EN cc-by-nc The Korean Journal of Internal Medicine 2005-01-01

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclopolymerization of diethyl dipropargylmalonate by transition metal catalystsMun Sam Ryoo, Won Chul Lee, and Kwon ChoiCite this: Macromolecules 1990, 23, 12, 3029–3031Publication Date (Print):June 1, 1990Publication History Published online1 May 2002Published inissue 1 June 1990https://pubs.acs.org/doi/10.1021/ma00214a001https://doi.org/10.1021/ma00214a001research-articleACS PublicationsRequest reuse permissionsArticle...

10.1021/ma00214a001 article EN Macromolecules 1990-06-01

We analyze the deformability of individual red blood cells (RBCs) using SiCMA technology. Our approach is adequate to quickly measure large numbers in heterogeneous populations. Individual are trapped a large-scale array micro-wells, and dielectrophoretic (DEP) force applied deform cells. The simple structures micro-wells DEP electrodes facilitate analysis thousands RBCs parallel. This unique method allows correlation cell deformation with surface cytosolic characteristics define...

10.1063/1.4704923 article EN Applied Physics Letters 2012-04-23
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