Melanoma skin cancer is one of the most dangerous cancers and main cause skin-cancer-related mortality. Hyaluronic acid (HA) has been used as an effective transdermal delivery carrier chemical drugs biopharmaceuticals. In this work, a nanographene oxide–HA conjugate (NGO–HA) was synthesized for photothermal ablation therapy melanoma using near-infrared (NIR) laser. Confocal microscopy ex vivo bioimaging clearly visualized remarkable NGO–HA to tumor tissues in mice, which might be ascribed...

A wearable surface-enhanced Raman scattering (SERS) sensor has been developed as a patch type to utilize molecular sweat sensor. Here, the SERS is designed comprise sweat-absorbing layer, which an interface human skin, active and dermal protecting layer that prevents damage contaminations. silk fibroin protein film (SFF) basement absorbs aqueous solutions filtrates molecules larger than nanopores created in β-sheet matrix of SFF. On SFF plasmonic silver nanowire (AgNW) formed enhance signal...

Abstract Microplastics (MPs) are present not only in the environment but also drinking water, food, and consumer products. These MPs being toxic, carcinogenic, endocrine disrupting, genetic risk creators cause several diseases. Despite various approaches, development of onsite applicable, facile, quick MP detection methods is still challenging. Here, 3D‐plasmonic gold nanopocket (3D‐PGNP) nanoarchitecture formed on a paper substrate for simultaneous filtration detection. The paper‐based...

Abstract Optical properties of afterglow luminescent particles (ALPs) in mechanoluminescence (ML) and mechanical quenching (MQ) have attracted great attention for diverse technological applications. However, these unique phenomena need to be more clearly explained the specific photonic application. Here, ALPs are designed development a wearable rewritable display system as communication toolbox under dark conditions or underwater environments with limited communication. This demonstrates...

Fluorescent nanosized carbon dots (Cdots) are an emerging bioimaging agent with excellent chemical inertness and marginal cytotoxicity in comparison to widely used semiconductor quantum dots. In this work, we report the application of Cdots for real time target specific delivery hyaluronic acid (HA) derivatives. Polyethylene glycol (PEG) diamine-capped were synthesized by pyrolysis citric a hot solvent. The showed strong fluorescence under UV excitation emission properties dependending on...

Gold nanoparticles (AuNPs) have been extensively investigated as an emerging delivery carrier of various biopharmaceuticals. Instead nonspecific polyethylene glycol (PEG) conjugated interferon α (IFNα) for the clinical treatment hepatitis C virus (HCV) infection, in this work, a target-specific long-acting system IFNα was successfully developed using hybrid materials AuNP and hyaluronic acid (HA). The HA-AuNP/IFNα complex prepared by chemical binding thiolated HA physical to AuNP. According...

Metabolomics shows tremendous potential for the early diagnosis and screening of cancer. For clinical application as an effective diagnostic tool, however, improved analytical methods complex biological fluids are required. Here, we developed a reliable rapid urine analysis system based on surface-enhanced Raman spectroscopy (SERS) using 3D-stacked silver nanowires (AgNWs) glass fiber filter (GFF) sensor applied it to pancreatic cancer prostate Urine samples were pretreated with...

Abstract Despite wide applications of bone morphogenetic protein–2 (BMP‐2), there are few methods to incorporate BPM‐2 within polymeric scaffolds while maintaining biological activity. Solid free‐form fabrication (SFF) tissue‐engineering scaffold is successfully carried out with poly(lactic‐ co ‐glycolic acid) grafted hyaluronic acid (HA‐PLGA) encapsulating intact BMP‐2/poly(ethylene glycol) (PEG) complex. HA‐PLGA conjugate synthesized in dimethyl sulfoxide (DMSO) by the conjugation reaction...

Titanium (Ti) and its alloys with a high mechanical strength small diameter can be effectively exploited for minimally invasive dental implantation. Here, we report multipass caliber-rolled Ti alloy of Ti13Nb13Zr (MPCR-TNZ) strong fatigue characteristics. For further applications, MPCR-TNZ was surface-modified reduced graphene oxide (RGO) loaded osteogenic dexamethasone (Dex) via π–π stacking on the graphitic domain RGO. The Dex-loaded RGO-MPCR-TNZ (Dex/RGO-MPCR-TNZ) resulted in...

Light-absorbing nanoparticles for localized heat generation in tissues have various biomedical applications diagnostic imaging, surgery, and therapies. Although numerous plasmonic carbon-based with strong optical absorption been developed, their clearance, potential cytotoxicity, long-term safety issues remain unresolved. Here, we show that "generally regarded as safe (GRAS)" melanoidins prepared from glucose amino acid offer a high light-to-heat conversion efficiency, biocompatibility,...

A dual-diagnostic system of endom­icroscope and microneedle sensor is developed to demonstrate high-resolution imaging combined with electrical real-time detection NO released from cancer tissues. The can be a new platform for facile, precise, rapid, accurate cancers in various biomedical applications. As service our authors readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may re-organized online delivery, but not copy-edited or...

A surface-enhanced Raman scattering (SERS) sensor comprising silver nanowires (AgNWs) and genetically engineered M13 bacteriophages expressing a tryptophan–histidine–tryptophan (WHW) peptide sequence (BPWHW) was fabricated by simple mixing of BPWHW AgNW solutions, followed vacuum filtration onto glass-fiber filter paper (GFFP) membrane. The AgNWs stacked on the GFFP formed high density SERS-active hot spots at points nanowire intersections, surface-coated functioned as bioreceptor for...

Abstract Plasmonic biosensors have demonstrated superior performance in detecting various biomolecules with high sensitivity through simple assays. Scaled‐up, reproducible chip production a density of hotspots large area has been technically challenging, limiting the commercialization and clinical translation these biosensors. A new fabrication method for 3D plasmonic nanostructures density, volume therefore inherently improved detection capabilities is developed. Specifically, Au...

The rapid detection of bacterial metabolites responsible for cell communication is important the early diagnosis infection and treatment with appropriate antibiotics. Surface-enhanced Raman spectroscopy (SERS) has provided amplified molecular fingerprints, serving as one most promising nondestructive label-free direct methods. However, analysis complex cultures using conventional SERS approach difficult. Here, we design a new paper-based 3D substrate establish facile one-pot Au...

Over the past 45 years, discovery of surface-enhanced Raman scattering (SERS), which enhances molecules absorbed on or near nanostructured metal surfaces, has brought significant potential as a powerful spectroscopic and analytical technique for various fields ultrasensitive sensing applications. In preference to rigid substrates, recent advances in development flexible SERS sensors have enabled fulfillment practical on-site diagnostic applications with rapid efficient sampling approaches....

Abstract Rapid and precise acute myocardial infarction (AMI) diagnosis is essential for preventing patient death. In addition, the complementary roles of creatine kinase muscle brain (CK‐MB) cardiac troponin I (cTnI) biomarkers in early late stages AMI demand their simultaneous detection, which difficult to implement using conventional fluorescence electrochemical technologies. Here, a nanotechnology‐based one‐stop immuno‐surface‐enhanced Raman scattering (SERS) detection platform reported...

A label-free detection method for noninvasive biofluids enables rapid on-site disease screening and early-stage cancer diagnosis by analyzing metabolic alterations. Herein, we develop three-dimensional plasmonic hexaplex nanostructures coated on a paper substrate (3D-PHP). This flexible highly absorptive 3D-PHP sensor is integrated with commercial saliva collection tube to create an efficient sensing platform lung via surface-enhanced Raman scattering (SERS) measurement of human saliva. The...

This paper reports the twisted and coiled soft actuator (abbreviated with STCA) spandex fiber. The STCA exhibits higher actuation strain at lower temperature than previous nylon actuators NTCAs). While NTCAs are fabricated using a twist-insertion process until coils formed, new method is developed to fabricate ultra-stretch of spandex, whereby again after coil has been formed. A 6-gear-twist-insertion device that increases stability fabrication speed STCA. superior performance exhibited by...

A nano graphene oxide–hyaluronic acid (NGO–HA) conjugate was successfully prepared for target specific delivery of an anti-cancer drug loaded by π–π stacking via HA receptor mediated endocytosis. In vitro tests confirmed the pH dependent release and effect complex.