A5100452198- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Natural Products and Biological Research
- Bone Metabolism and Diseases
- Characterization and Applications of Magnetic Nanoparticles
- Luminescence Properties of Advanced Materials
- Photoacoustic and Ultrasonic Imaging
- Shoulder Injury and Treatment
- Lanthanide and Transition Metal Complexes
- Quantum Dots Synthesis And Properties
- Nanocluster Synthesis and Applications
- Graphene and Nanomaterials Applications
- Bone Tissue Engineering Materials
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- Mesoporous Materials and Catalysis
- Mesenchymal stem cell research
- Metal-Organic Frameworks: Synthesis and Applications
- Nanoparticles: synthesis and applications
- Advanced Cellulose Research Studies
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Coronary Interventions and Diagnostics
- Bone health and treatments
Michigan State University
2019-2025
Kumoh National Institute of Technology
2024
Korea Research Institute of Bioscience and Biotechnology
2024
National Institute of Food and Drug Safety Evaluation
2024
Yonsei University
2014-2024
Kyung Hee University
2010-2024
Nongwoo Bio (South Korea)
2024
Daegu University
2018-2024
National Academy of Agricultural Science
2014-2023
Konkuk University
2019-2022
Magnetic, fluorescent core–shell nanoparticles consist of a single Fe3O4 nanocrystal core and dye-doped mesoporous silica shell with poly(ethylene glycol) coating (see picture TEM images schematic depictions). These can be used as magnetic resonance fluorescence imaging agents, drug delivery vehicles, thus making them novel candidates for simultaneous cancer diagnosis therapy. Detailed facts importance to specialist readers are published "Supporting Information". Such documents...
Highly versatile nanocomposite nanoparticles were synthesized by decorating the surface of mesoporous dye-doped silica with multiple magnetite nanocrystals. The superparamagnetic property nanocrystals enabled to be used as a contrast agent in magnetic resonance (MR) imaging, and dye molecule framework imparted optical imaging modality. Integrating multitude on resulted remarkable enhancement MR signal due synergistic magnetism. An anticancer drug, doxorubicin (DOX), could loaded pores...
Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated showed protective effects ROS-induced cell death in vitro. Optimal doses of reduced infarct volumes the rate vivo. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note: The publisher is...
Mesoporous silica-coated hollow manganese oxide (HMnO@mSiO(2)) nanoparticles were developed as a novel T(1) magnetic resonance imaging (MRI) contrast agent. We hypothesized that the mesoporous structure of nanoparticle shell enables optimal access water molecules to core, and consequently, an effective longitudinal (R(1)) relaxation enhancement protons, which value was measured be 0.99 (mM(-1)s(-1)) at 11.7 T. Adipose-derived mesenchymal stem cells (MSCs) efficiently labeled using...
Soluble β-amyloid (Aβ) oligomers impair synaptic plasticity and cause loss associated with Alzheimer's disease (AD). We report that murine PirB (paired immunoglobulin-like receptor B) its human ortholog LilrB2 (leukocyte B2), present in brain, are receptors for Aβ oligomers, nanomolar affinity. The first two extracellular immunoglobulin (Ig) domains of mediate this interaction, leading to enhanced cofilin signaling, also seen AD brains. In mice, the deleterious effect on hippocampal...
The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in scavenging reactive oxygen species (ROS). In particular, is largely responsible for removing O2− .OH that are associated with inflammatory response cell death. synthesis reported 2 nm ceria–zirconia nanoparticles (CZ NPs) possess higher Ce3+/Ce4+ ratio faster conversion from Ce4+ to than those exhibited by nanoparticles. obtained Ce0.7Zr0.3O2 (7CZ) NPs greatly improve ROS performance, thus regulating cells...
Ag+ ions are a well-known antibacterial agent, and Ag nanoparticles act as reservoir of these for targeted therapy bacterial infections. However, there no tools to effectively trigger monitor the release from nanoparticles. Photoacoustic (PA) imaging is an emerging noninvasive tool, gold nanorods (AuNRs) excellent contrast agent PA imaging. In this work, we developed Au/Ag hybrid by coating AuNRs with silver (Ag), which decreased their photoacoustic signal. The as-prepared, Ag-coated Au...
Implantable endovascular devices such as bare metal, drug eluting, and bioresorbable stents have transformed interventional care by providing continuous structural mechanical support to many peripheral, neural, coronary arteries affected blockage. Although effective in achieving immediate restoration of blood flow, the long-term re-endothelialization inflammation induced are difficult diagnose or treat. Here we present nanomaterial designs integration strategies for electronic stent with...
The growth of one metal-organic framework (MOF) on another MOF for constructing a heterocompositional hybrid is an interesting research topic because the curiosity regarding occurrence this phenomenon and value MOFs as multifunctional materials or routes fine-tuning properties. In particular, anisotropic fascinating development possessing atypical shapes heterostructures abnormal Herein, we clarify understanding behavior secondary initial template, such isotropic ways associated with their...
Magnetische, fluoreszierende Kern-Schale-Nanopartikel, die aus einem Fe3O4-Nanokristallkern und einer farbstoffdotierten mesoporösen Kieselgelhülle mit Polyethylenglycol-Beschichtung bestehen (siehe TEM-Bilder schematische Darstellung), können als Magnetresonanz- Imaging-Agentien sowie zum Wirkstofftransport eingesetzt werden, was sie zu neuartigen Kandidaten für eine simultane Krebsdiagnose -therapie macht. Detailed facts of importance to specialist readers are published as "Supporting...
Here, it is shown that graphene oxide (GO) can be utilized as both a cell‐adhesion substrate and growth factor protein‐delivery carrier for the chondrogenic differentiation of adult stem cells. Conventionally, cells achieved by culturing in pellets adding protein transforming factor‐β3 (TGF‐β3), factor, to culture medium. However, mainly provide cell‐cell interaction diffusional limitation TGF‐β3 may occur inside pellet these factors limit In this study, GO sheets (size = 0.5–1 μm) were...
It is well known that ultraviolet light activates mitogen-activated protein (MAP) kinase by increasing the reactive oxygen species (ROS) in body, enhancing activating 1(AP-1) complexes (c-Jun and c-Fos), matrix metalloproteinases (MMPs) degrading collagen elastin. In this study, we confirmed polyphenolic rich Spatholobus suberectus (SS) stem extracts suppressed (UV)-induced photo-aging. The major active components of SS were identified as gallic acid, catechin, vanillic syringic acid...
Acoustic imaging is affordable and accessible without ionizing radiation. Photoacoustic increases the contrast of traditional ultrasound can offer good spatial resolution when used at high frequencies with excellent temporal resolution. Prussian blue nanoparticles (PBNPs) are an emerging photoacoustic agent strong optical absorption in near-infrared region. In this study, we developed a simple efficient method to label human mesenchymal stem cells (hMSCs) PBNPs imaged them imaging. First,...
Developing in vivo cell tracking is an important prerequisite for further development of cell-based therapy. So far, few computed tomography (CT) studies have been described due to its notoriously low sensitivity and lack efficient labeling protocols. A simple method presented render human mesenchymal stem cells (hMSCs) sufficiently radiopaque by complexing 40 nm citrate-stabilized gold nanoparticles (AuNPs) with poly-l-lysine (PLL) rhodamine B isothiocyanate (RITC). AuNP-PLL-RITC does not...
Rheumatoid arthritis (RA) is an autoimmune disease that affects 1-2% of the human population worldwide, and effective therapies with targeted delivery for local immune suppression have not been described. We address this problem by developing a novel theranostic nanoparticle RA assessed its therapeutic targeting effects under image-guidance.
Nanomaterials are promising tools in water remediation because of their large surface area and unique properties compared to bulky materials. We synthesized an organosilica nanoparticle (OSNP) tuned its composition for anionic dye removal. The adsorption mechanisms electrostatic attraction hydrogen bonding between the amine on OSNP dye, charge can be adsorb either or cationic dyes. Using phenol red as a model we studied effect group, pH, ionic strength, time, concentration, nanomaterial mass...
We demonstrate the first enzymatic hydrogenation of 2-hexenedioic acid and muconic to adipic using enoate reductases (ERs).
Glioblastoma is one of the most aggressive and invasive types brain cancer with a 5-year survival rate 6.8%. With limited options, patients often have poor quality life are moved to palliative care after diagnosis. As result, there an extreme need for novel theranostic method that allows early diagnosis noninvasive treatment as current peptide-based delivery standards may off-target effects. Prussian Blue nanoparticles (PBNPs) recently been investigated photoacoustic imaging (PAI)...