A5101802194- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Genetic and Kidney Cyst Diseases
- Ginseng Biological Effects and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Nanomaterials in Catalysis
- Venous Thromboembolism Diagnosis and Management
- Food Quality and Safety Studies
- Diverse Approaches in Healthcare and Education Studies
- Atrial Fibrillation Management and Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Renal and related cancers
- Metabolism, Diabetes, and Cancer
- Neurological Disorders and Treatments
- Conducting polymers and applications
- Transition Metal Oxide Nanomaterials
- Real-time simulation and control systems
- Garlic and Onion Studies
- Silk-based biomaterials and applications
- 3D Printing in Biomedical Research
- Crystallization and Solubility Studies
- Neurological Disease Mechanisms and Treatments
- Blood properties and coagulation
- MicroRNA in disease regulation
Seoul National University Bundang Hospital
2013-2025
Asan Medical Center
2019-2024
Korea University
2010-2024
Sookmyung Women's University
2013-2024
Inje University Ilsan Paik Hospital
2024
University of Seoul
2021-2024
University of Ulsan
2013-2024
Ulsan College
2019-2024
Bridge University
2024
Harvard University Press
2024
The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in scavenging reactive oxygen species (ROS). In particular, is largely responsible for removing O2− .OH that are associated with inflammatory response cell death. synthesis reported 2 nm ceria–zirconia nanoparticles (CZ NPs) possess higher Ce3+/Ce4+ ratio faster conversion from Ce4+ to than those exhibited by nanoparticles. obtained Ce0.7Zr0.3O2 (7CZ) NPs greatly improve ROS performance, thus regulating cells...
International guidelines recommend avoiding intravenous thrombolysis (IVT) in patients with ischemic stroke who have a recent intake of direct oral anticoagulant (DOAC). To determine the risk symptomatic intracranial hemorrhage (sICH) associated use IVT DOAC ingestion. This international, multicenter, retrospective cohort study included 64 primary and comprehensive centers across Europe, Asia, Australia, New Zealand. Consecutive adult received (both without thrombectomy) were included....
Abstract Piezocatalytic cancer therapy, in which piezoelectric nanomaterials generate reactive oxygen species (ROS) via piezocatalytic redox reactions under mechanical stress, has emerged as an effective strategy for treatment. However, the inherent hypoxia tumor microenvironments enormously restricts its efficacy. To address this issue, acid‐degradable Janus‐type multicompartmental carriers able to separately encapsulate gold nanoparticle‐coated poly(ethylene glycol)‐modified zinc oxide...
Compound K (CK) is a major intestinal metabolite of ginsenosides derived from ginseng radix. Although antidiabetic and antihyperlipidemic activities CK have been investigated in recent years, action mechanism remains poorly understood. Therefore, we examined whether affects the lipid metabolism insulin-resistant HepG2 human hepatoma cells. In this study, significant increase AMP-activated protein kinase (AMPK) was observed when cells were treated with CK. Activation AMPK also demonstrated by...
One of the properties human breast cancer cells is stemness, which characterized by self-renewal capability and drug resistance. Protein kinase D1 (PRKD1) functions as a key regulator many cellular processes downregulated in invasive cells. In this study, we found that PRKD1 was upregulated MCF-7-ADR Additionally, discovered expression negatively regulated miR-34a binding to 3'-UTR. increased following performance tumorsphere formation assay We also reduction ectopic or siRNA treatment...
Among various bioreactors used in the field of tissue engineering and regenerative medicine, a magnetic bioreactor is more capable providing steady force to cells while avoiding direct manipulation materials. However, most them are complex difficult fabricate, with drawbacks terms consistency biocompatibility. In this study, system hydrogel were manufactured by single-stage three-dimensional (3D) printing digital light processing (DLP) technique for differentiation myoblast cells. The was...
In this work, we prepared octa-hydroxyhexyl viologen-substituted polyhedral oligomeric silsesquioxane (OHHV-POSS) as an organic–inorganic composite material applicable for large-area flexible electrochromic devices (FECDs). The hybrid structure supported by the POSS cage and enhanced interaction between hydroxyl end-groups lithium salts can effectively increase ionic conductivity of ion gel films, thereby improving performance capabilities. Homogeneous was obtained with polyvinyl butyral a...
Although compound K (CK), an intestinal metabolite of ginseng protopanaxadiol saponins, has been known to induce apoptosis in various cancer cells, association AMP-activated protein kinase (AMPK) with HT-29 colon cells remains unclear. We hypothesized that CK may exert anticancer activity through modulating the AMPK pathway cells. CK-induced was associated disruption mitochondrial membrane potential, release apoptogenic factors (cytochrome c and apoptosis-inducing factor) from mitochondria,...
The susceptibility vessel sign (SVS) is a hypointense signal visualized because of the effect thrombi, sensitively detected on susceptibility-weighted magnetic resonance imaging. relationship SVS parameters with stroke subtype and recanalization status after endovascular treatment remains uncertain.The data from 89 patients acute caused by anterior circulation infarcts who underwent imaging before were examined. Independent reviewers, blinded to status, measured diameter, length, estimated...
The current guideline recommends moderate- to vigorous-intensity physical activity (PA) at least 40 min/day for 3 4 days/week. Although recent evidence has demonstrated that low-dose PA could reduce cardiovascular mortality, the relationship between and risk of stroke remains uncertain.Using data from a nation-wide sample cohort in Korea, we examined 336 326 individuals who received general health examination 2009 2010. Level was assessed using questionnaire weekly frequencies regarding...
Abstract The two oxidation states of ceria nanoparticles, Ce 3+ and 4+ , play a pivotal role in scavenging reactive oxygen species (ROS). In particular, is largely responsible for removing O 2 − . OH that are associated with inflammatory response cell death. synthesis reported nm ceria–zirconia nanoparticles (CZ NPs) possess higher /Ce ratio faster conversion from to than those exhibited by nanoparticles. obtained 0.7 Zr 0.3 (7CZ) NPs greatly improve ROS performance, thus regulating cells...
Background and Purpose- Despite early aneurysm repair aggressive management for complications, subarachnoid hemorrhage (SAH) results in at least 25% mortality rate 50% persistent neurological deficit. We investigated whether ceria nanoparticles which have potent antioxidative activities can protect against via attenuating fatal brain injuries. Methods- Uniform, 3 nm, water-dispersed were prepared from short sol-gel reaction of cerium (III) ions with aminocaproic acid aqueous phase. SAH was...
Colorectal cancer (CRC) as the second leading cause of global deaths poses critical challenges in clinical settings. Cancer-derived small extracellular vesicles (sEVs), which are secreted by cells, have been shown to mediate tumor development, invasion, and even metastasis, thus received increasing attention for development diagnostic or therapeutic platforms. In present study, sEV-targeted systematic evolution ligands exponential enrichment (E-SELEX) is developed generate a high-quality...
Abstract Alpha‐2‐Glycoprotein 1, Zinc‐binding (AZGP1, ZAG) is a secreted protein that synthesized by adipocytes and epithelial cells; it downregulated in several malignancies such as breast, prostate, liver lung cancers. However, its function remains unclear cholangiocarcinoma (CCA). Here, we evaluated the impact AZGP1 CCA using Gene Expression Omnibus (GEO) GEPIA. In addition, analysed expression quantitative reverse transcription PCR western blotting. of was nearly deficient patients cell...
Background Elevated heart rate in patients with acute ischemic stroke is associated increased risk of mortality. Beta‐blocker therapy well known to reduce rate. Methods and Results This study was a post hoc analysis maximum rates ≥100 bpm. use, assessed on the eighth day after index stroke, categorized as persistent or nonpersistent based usage up 39 months. The primary outcome composite recurrence, myocardial infarction, mortality within first year. Long‐term mortality, secondary outcome,...