A5101943448- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Neuroprotection
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Natural product bioactivities and synthesis
- Calpain Protease Function and Regulation
- Healthcare and Venom Research
- Cholinesterase and Neurodegenerative Diseases
- Phytochemistry and Biological Activities
- Computational Drug Discovery Methods
- Anesthesia and Neurotoxicity Research
- Menopause: Health Impacts and Treatments
- Biological and pharmacological studies of plants
- Chemical synthesis and alkaloids
- Autism Spectrum Disorder Research
- Phytochemicals and Antioxidant Activities
- Botanical Research and Applications
- Genetics and Neurodevelopmental Disorders
- Estrogen and related hormone effects
- Signaling Pathways in Disease
- Curcumin's Biomedical Applications
- Biochemical effects in animals
- Pharmacological Effects of Natural Compounds
Kyung Hee University
2011-2025
Kangbuk Samsung Hospital
2022
Sungkyunkwan University
2022
Soonchunhyang University Hospital
2018
Korea Institute of Science and Technology
2009-2017
Convergence Research Center for Diagnosis Treatment and Care System of Dementia
2016-2017
Hepatitis B Foundation
2016
Chungnam National University
2014
To search for secondary metabolites of Alnus hirsuta (Betulaceae), various chromatographic separations the ethyl acetate soluble fraction stem bark A. led to isolation a new diarylheptanoid glycoside, (3R)-1,7-bis-(4-dihydroxyphenyl)-3-heptanol 3-O-β-D-glucopyranosyl(1→3)-β-D-xylopyranoside (13) and twelve derivatives, namely, oregonin (1), rubranoside A (2), hirsutanonol 5-O-β-D-glucopyranoside (3), B (4), C (5), (6), hirsutenone (7), (5S)-O-methylhirsutanonol (8), platyphylloside (9),...
As the elderly population is increasing, Alzheimer's disease (AD) has become a global issue and many clinical trials have been conducted to evaluate treatments for AD. these failed, development of new theraphies AD with fewer adverse effects remains challenge. In this study, we examined Theracurmin on cognitive decline using 5XFAD mice, an mouse model. more bioavailable form curcumin, generated submicron colloidal dispersion. Mice were treated (100, 300 1,000 mg/kg) 12 weeks subjected novel...
Background and Purpose Alzheimer's disease (AD) is the most prevalent associated with cognitive dysfunction. Current AD therapeutic agents have several gastrointestinal or psychological adverse effects therefore, novel fewer must be developed. Previously, we demonstrated that oleanolic acid, which similar in chemical structure to maslinic ameliorates impairment through activation of tropomyosin receptor kinase (TrkB)–ERK–cAMP response element‐binding protein (CREB) phosphorylation increased...
The complex molecular cascades of ischemic tolerance in brain cells remain unclear. Recently, sphingolipid-related metabolite ceramide has been implicated as a second messenger many biological functions, including neuronal survival and death. present study, therefore, examined the roles (Cer) induced by preconditioning with sublethal oxygen-glucose deprivation (OGD) using primary cultured cortical neurons rats. Preconditioning 1-h OGD produced robust neuroprotection against cell death lethal...
Chronic hepatitis B virus(HBV) infection is a major cause of liver related morbidity and mortality. HBV remains largely underdiagnosed in Asian American population, it also poorly linked to clinical care. We, therefore, assessed the prevalence evaluated linkage care among Korean Americans order develop strategic plans reduce impact high risk community.Serologic screening survey were provided 7157 adults (age 21-100) New Jersey between December 2009 June 2015. All participants tested for...
Mesenchymal stem cells (MSCs) could be a promising solution in the treatment of various diseases including chronic kidney disease (CKD). However, endoplasmic reticulum (ER) stress induced by ischemia area application limits integration and survival MSCs patients. In our study, we generated ER stress-induced conditions using P-cresol. As P-cresol is toxic compound accumulated body CKD patients induces apoptosis inflammation through reactive oxygen species (ROS), observed MSC activated...
The leaves of Aster glehni Fr. Schm. (Asteraceae) have been used to treat insomnia in Korea. Insomnia is a common adverse effect therapeutic agents for Alzheimer's disease (AD), and the control sleep disturbance may prevent dementia. We hypothesized that A. can attenuate cognitive dysfunctions observed AD. ameliorating effects ethanolic extract (AG-D) on memory dysfunction through Morris water maze test, passive avoidance Y-maze test. performed acetylcholinesterase (AChE) activity assay...
A botanical drug derived from the ethanolic extract composed of Clematis chinensis Osbeck (Ranunculaceae), Trichosanthes kirilowii Maximowicz (Cucurbitaceae) and Prunella vulgaris Linné (Lamiaceae) has been used to ameliorate rheumatoid arthritis as an ethical in Korea. In our study, we investigated effect this herbal complex (HCE) on schizophrenia-like behaviours induced by MK-801.HCE (30, 100 or 300 mg/kg, p.o) was orally administered male ICR mice a animal model MK-801. We conducted...