A5020206432- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Coronary Interventions and Diagnostics
- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- Cardiac Imaging and Diagnostics
- Graphene and Nanomaterials Applications
- Virus-based gene therapy research
- Bone Tissue Engineering Materials
- Advanced Nanomaterials in Catalysis
- 3D Printing in Biomedical Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Acute Myocardial Infarction Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Photoacoustic and Ultrasonic Imaging
- Supramolecular Self-Assembly in Materials
- Peripheral Artery Disease Management
- Nanomaterials for catalytic reactions
- Piperaceae Chemical and Biological Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Biopolymer Synthesis and Applications
- Seaweed-derived Bioactive Compounds
- Nanoparticles: synthesis and applications
- Advanced Photocatalysis Techniques
Incheon National University
2016-2025
Midwestern University
2024
Incheon Medical Center
2016-2020
Government of the Republic of Korea
2016-2020
Hanyang University Guri Hospital
2018
Korea University Medical Center
2016-2017
Korea University
2017
Soonchunhyang University
2016
The Wallace H. Coulter Department of Biomedical Engineering
2012-2014
Georgia Institute of Technology
2012-2014
Stimuli-responsive release: The high levels of reactive oxygen species (ROS) in prostate cancer cells can be exploited to trigger cancer-targeted gene delivery. A ROS-responsive thioketal-based cationic polymer was synthesized and functionalization with a cancer-targeting peptide led selective enhanced transfection (see scheme).
Stimuli‐responsive materials are so named because they can alter their physicochemical properties and/or structural conformations in response to specific stimuli. The stimuli be internal, such as physiological or pathological variations the target cells/tissues, external, optical and ultrasound radiations. In recent years, these have gained increasing interest biomedical applications due potential for spatially temporally controlled release of theranostic agents This article highlights...
Green synthesis of silver nanoparticles (AgNPs) has gained great interest as a simple and eco-friendly alternative to conventional chemical methods. In this study, AgNPs were synthesized by using extracts marine algae Ecklonia cava reducing capping agents. The formation aqueous extract was confirmed visually color change their surface plasmon resonance peak at 418 nm, measured UV-visible spectroscopy. size, shape, morphology the biosynthesized observed transmission electron microscopy...
Zinc oxide nanoparticles (ZnO NPs) generate reactive oxygen species and thus induce phototoxicity against bacteria cancer cells due to their photocatalytic effects under light irradiation. This review introduces discusses recent research regarding the utilization of ZnO NPs for light-triggered antibacterial anticancer activities.
Piezoelectric nanomaterials that can generate reactive oxygen species (ROS) by piezoelectric polarization under an external mechanical force have emerged as effective platform for cancer therapy. In this study, 2D WS2 nanosheets are functionalized with mitochondria-targeting triphenylphosphonium (TPP) ultrasound (US)-triggered, mitochondria-targeted piezodynamic addition, a glycolysis inhibitor (FX11) inhibit cellular energy metabolism is loaded into TPP- and poly(ethylene glycol)...
Abstract Piezocatalytic cancer therapy, in which piezoelectric nanomaterials generate reactive oxygen species (ROS) via piezocatalytic redox reactions under mechanical stress, has emerged as an effective strategy for treatment. However, the inherent hypoxia tumor microenvironments enormously restricts its efficacy. To address this issue, acid‐degradable Janus‐type multicompartmental carriers able to separately encapsulate gold nanoparticle‐coated poly(ethylene glycol)‐modified zinc oxide...
Oxidative stress and reduced pH are involved in many inflammatory diseases. This study describes a nanoparticle-based system that is responsive to both oxidative an environment effectively release its encapsulated curcumin, immune-modulatory agent with potent anti-inflammatory antioxidant capabilities. Because of the presence Förster resonance energy transfer between curcumin carrier, this also allowed us monitor intracellular behavior. The released upon triggering could efficiently reduce...
Silver nanoparticles (AgNPs) are gaining a great deal of attention in biomedical applications due to their unique physicochemical properties. In this study, green synthesis AgNPs was developed using seaweed polysaccharide fucoidan. The were further coated with chitosan form an electrolyte complex on the surface. chitosan⁻fucoidan complex-coated characterized UV-visible spectroscopy, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM). FT-IR results...
Sonodynamic therapy (SDT), wherein sonosensitizers irradiated with ultrasound (US) produce cytotoxic reactive oxygen species (ROS), has garnered great attention as a promising alternative to photodynamic owing the significantly increased depth of tissue penetration. The development nanocarriers that can selectively deposit into tumor tissues without systemic toxicity is crucial facilitate translation SDT clinical use. In this study, exosomes, class naturally occurring nanoparticles, were...
Sonodynamic therapy has shown promise as an effective alternative to conventional photodynamic owing its ability treat deep-seated tumors.However, the development of stimuli-responsive sonosensitizers with high biocompatibility faces a significant challenge.Methods: In this study, we developed dual desirable biosafety using extracellular vesicles (EVs), class naturally occurring nanoparticles.Indocyanine green (ICG), which functions both sonosensitizer and photoacoustic (PA) imaging agent,...
Glioblastoma (GBM) is the most aggressive malignant brain tumor and has a high mortality rate. Photodynamic therapy (PDT) emerged as promising approach for treatment of tumors. However, use PDT GBM been limited by its low blood‒brain barrier (BBB) permeability lack cancer-targeting ability. Herein, endothelial cell-derived extracellular vesicles (bEVs) were used biocompatible nanoplatform to transport photosensitizers into tumors across BBB. To enhance efficacy, photosensitizer chlorin e6...