A5002540920- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced Drug Delivery Systems
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- Micro and Nano Robotics
- Angiogenesis and VEGF in Cancer
- Graphene and Nanomaterials Applications
- Molecular Communication and Nanonetworks
- Antimicrobial Peptides and Activities
- Extracellular vesicles in disease
- Virus-based gene therapy research
- Bacteriophages and microbial interactions
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Lipid Membrane Structure and Behavior
- Pluripotent Stem Cells Research
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- Molecular Sensors and Ion Detection
- interferon and immune responses
- Sulfur Compounds in Biology
University of California, San Diego
2014-2024
State Key Laboratory of Medicinal Chemical Biology
2015-2023
Nankai University
2008-2023
Tianjin Institute of Pharmaceutical Research (China)
2018
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2018
Sichuan University
2015-2016
Chinese Academy of Sciences
2010-2012
Tsinghua University
2004
Significance Clinical evidence has indicated that the systemic spread of endotoxins from septic infection plays a crucial role in pathogenesis Gram-negative bacterial sepsis. However, currently there are no effective ways to manage diverse released by different genus, species, and strain. Herein, we demonstrate therapeutic potential macrophage-like nanoparticle for sepsis control through powerful two-step neutralization process: endotoxin first step followed cytokine sequestration second...
Synthetic nanoparticles coated with cellular membranes have been increasingly explored to harness natural cell functions toward the development of novel therapeutic strategies. Herein, we report on a unique bacterial membrane-coated nanoparticle system as new and exciting antibacterial vaccine. Using Escherichia coli model pathogen, collect outer membrane vesicles (OMVs) successfully coat them onto small gold (AuNPs) diameter 30 nm. The resulting AuNPs (BM-AuNPs) show markedly enhanced...
We report cellular nanosponges as an effective medical countermeasure to the SARS-CoV-2 virus. Two types of are made plasma membranes derived from human lung epithelial type II cells or macrophages. These display same protein receptors, both identified and unidentified, required by for entry. It is shown that, following incubation with nanosponges, neutralized unable infect cells. Crucially, nanosponge platform agnostic viral mutations potentially species, well. As long target virus remains...
Platelet-mimicking nanoparticles enable the targeted delivery of small interfering RNA to tumors for anticancer therapy.
Ag+ ions are a well-known antibacterial agent, and Ag nanoparticles act as reservoir of these for targeted therapy bacterial infections. However, there no tools to effectively trigger monitor the release from nanoparticles. Photoacoustic (PA) imaging is an emerging noninvasive tool, gold nanorods (AuNRs) excellent contrast agent PA imaging. In this work, we developed Au/Ag hybrid by coating AuNRs with silver (Ag), which decreased their photoacoustic signal. The as-prepared, Ag-coated Au...
The efforts of detecting bioactive targets with complex, dynamic, and unknown molecular profiles have inspired the development various biosensor platforms. Herein, we report a cell-membrane-modified field effect transistor (FET) as function-based nanosensor for detection quantitative measurement numerous toxins biological samples. By coating carbon nanotube FETs natural red blood cell membranes, resulting biomimetic can selectively interact absorb broad-spectrum hemolytic regardless their...
Adsorbing small charged nanoparticles onto the outer surfaces of liposomes has become an effective strategy to stabilize against fusion prior "seeing" target bacteria, yet allow them fuse with bacteria upon arrival at infection sites. As a result, nanoparticle-stabilized have emerging drug delivery platform for treatment various bacterial infections. To facilitate translation this clinical tests and uses, herein we integrate hydrogel technology more sustained topical delivery. The...
Platelets possess distinct surface moieties responsible for modulating their adhesion to various disease-relevant substrates involving vascular damage, immune evasion, and pathogen interactions. Such broad biointerfacing capabilities of platelets have inspired the development platelet-mimicking drug carriers that preferentially target payloads disease sites enhanced therapeutic efficacy. Among these carriers, platelet membrane-coated nanoparticles (denoted 'PNPs') made by cloaking synthetic...
Abstract Anti‐adhesion therapies interfere with the bacterial adhesion to host and thus avoid direct disruption of cycles for killing, which may alleviate resistance development. Herein, an anti‐adhesion nanomedicine platform is made by wrapping synthetic polymeric cores outer membranes. The resulting bacterium‐mimicking nanoparticles (denoted “OM‐NPs”) compete source bacteria binding host. “top‐down” fabrication OM‐NPs avoids identification adhesins bypasses design agonists targeting these...
Inspired by the natural pathogen-host interactions and adhesion, this study reports on development of a novel targeted nanotherapeutics for treatment
A hybrid nanomaterial integrating unique toxin-absorbing nanosponges with hydrogel is developed for local antivirulence therapy against methicillin-resistant Staphylococcus aureus (MRSA) infection. The composition optimized to retain toxin after administration while not compromising transport into the gel neutralization. Mice treated nanosponge–hydrogel show markedly reduced MRSA skin lesion development.
Therapeutic enzymes used for genetic disorders or metabolic diseases oftentimes suffer from suboptimal pharmacokinetics and stability. Nanodelivery systems have shown considerable promise improving the performance of enzyme therapies. Here, we develop a cell membrane-camouflaged metal-organic framework (MOF) system with enhanced biocompatibility functionality. The MOF core can efficiently encapsulate while maintaining their bioactivity. After introduction natural membrane coatings, resulting...
Adsorbing small charged nanoparticles onto liposome surfaces to stabilize them against fusion and payload leakage has resulted in a new class of liposomes capable environment-responsive drug delivery. Herein, we engineered formulation with lipid composition sensitive bacterium-secreted phospholipase A2 (PLA2) adsorbed chitosan-modified gold (AuChi) the surface. The resulting AuChi-stabilized (AuChi-liposomes) showed prohibited activity negligible leakage. However, upon exposure either...
The increasing popularity of biomimetic design principles in nanomedicine has led to therapeutic platforms with enhanced performance and biocompatibility. This includes the use naturally derived cell membranes, which can bestow nanocarriers cell-specific functionalities. Herein, we report on a strategy enabling efficient encapsulation drugs via remote loading into membrane vesicles from red blood cells. is accomplished by supplementing additional cholesterol, stabilizing nanostructure...
The design of organic photothermal agents (PTAs) for in vivo applications face a demanding set performance requirements, especially intense NIR-absorptivity and sufficient photobleaching resistance. J-aggregation offers facile way to tune the optical properties dyes, thus providing general platform PTAs with desired performance. Herein, we present supramolecular strategy build water-stable, nonphotobleaching, NIR-absorbing nano-PTA (J-NP) from halogenated BODIPY dyes (BDP) efficient therapy....
Active transport of gas molecules is critical to preserve the physiological functions organisms. Oxygen, as most essential molecule, plays significant roles in maintaining metabolism and viability cells. Herein, we report a nanomotor-based delivery system that combines fast propulsion acoustically propelled gold nanowire nanomotors (AuNW) with high oxygen carrying capacity red blood cell membrane-cloaked perfluorocarbon nanoemulsions (RBC-PFC) for active intracellular oxygen. The kinetics...
Infections caused by multidrug-resistant Gram-negative bacteria have emerged as a major threat to public health worldwide. The high mortality and prevalence, along with the slow pace of new antibiotic discovery, highlight necessity for disease management paradigms. Here, we report on development multiantigenic nanotoxoid vaccine based macrophage membrane-coated nanoparticles eliciting potent immunity against pathogenic Pseudomonas aeruginosa. design this biomimetic nanovaccine leverages...
The coronavirus SARS-CoV-2 can survive in wastewater for several days with a potential risk of waterborne human transmission, hence posing challenges containing the virus and reducing its spread. Herein, we report on an active biohybrid microrobot system that offers highly efficient capture removal target from various aquatic media. algae-based is fabricated by using click chemistry to functionalize microalgae angiotensin-converting enzyme 2 (ACE2) receptor against spike protein. resulting...