A5011324779- Catalytic Processes in Materials Science
- Nanoparticle-Based Drug Delivery
- Metal-Organic Frameworks: Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Catalysis and Oxidation Reactions
- Particle Accelerators and Free-Electron Lasers
- Particle accelerators and beam dynamics
- Advanced Chemical Physics Studies
- Magnetism in coordination complexes
- Micro and Nano Robotics
- Advanced Drug Delivery Systems
- CO2 Reduction Techniques and Catalysts
- Gyrotron and Vacuum Electronics Research
- Hemoglobin structure and function
- Lanthanide and Transition Metal Complexes
- Immune Cell Function and Interaction
- Nanocluster Synthesis and Applications
- Organometallic Compounds Synthesis and Characterization
- Nonlinear Optical Materials Research
- Carbon dioxide utilization in catalysis
- RNA Interference and Gene Delivery
- Bacteriophages and microbial interactions
- Air Quality Monitoring and Forecasting
- Superconducting Materials and Applications
- Molecular Communication and Nanonetworks
Fudan University
2010-2025
University of California, San Diego
2017-2022
Massachusetts Institute of Technology
2019-2022
Peking University
2002-2018
Army Logistics University
2018
Boston College
2013-2017
Chestnut Hill College
2015
Southwest Petroleum University
2014
Zhejiang Sci-Tech University
2010
Northeast Normal University
2008-2009
We have developed a general synthetic route to encapsulate small molecules in monodisperse zeolitic imid-azolate framework-8 (ZIF-8) nanospheres for drug delivery. Electron microscopy, powder X-ray diffraction, and elemental analysis show that the small-molecule-encapsulated ZIF-8 are uniform 70 nm particles with single-crystalline structure. Several molecules, including fluorescein anticancer camptothecin, were encapsulated inside of framework. Evaluation fluorescein-encapsulated MCF-7...
Drug-loaded urease-powered Janus cell robots enhance binding efficiency with biological targets and improve therapeutic efficacy.
Platelet-mimicking nanoparticles enable the targeted delivery of small interfering RNA to tumors for anticancer therapy.
The efforts of detecting bioactive targets with complex, dynamic, and unknown molecular profiles have inspired the development various biosensor platforms. Herein, we report a cell-membrane-modified field effect transistor (FET) as function-based nanosensor for detection quantitative measurement numerous toxins biological samples. By coating carbon nanotube FETs natural red blood cell membranes, resulting biomimetic can selectively interact absorb broad-spectrum hemolytic regardless their...
Composite nanomaterials are attractive for a diverse range of applications in catalysis, plasmonics, sensing, imaging, and biology. In such composite nanomaterials, it is desired, yet still challenging to create controlled alignment between components with lattices disparate scales. To address this challenge, we report new concept colloidal synthesis, which self-assembled molecular layers control the materials during synthesis. illustrate concept, cetyltrimethylammonium bromide (CTAB)...
Abstract Anti‐adhesion therapies interfere with the bacterial adhesion to host and thus avoid direct disruption of cycles for killing, which may alleviate resistance development. Herein, an anti‐adhesion nanomedicine platform is made by wrapping synthetic polymeric cores outer membranes. The resulting bacterium‐mimicking nanoparticles (denoted “OM‐NPs”) compete source bacteria binding host. “top‐down” fabrication OM‐NPs avoids identification adhesins bypasses design agonists targeting these...
Inspired by the natural pathogen-host interactions and adhesion, this study reports on development of a novel targeted nanotherapeutics for treatment
Abstract The effect of lattice strain on the catalytic properties Pd nanoparticles is systematically studied. Synthetic strategies for preparation a series shape‐controlled nanocrystals with generated from different sources has been developed. All these were created same capping agent under similar reaction conditions. First, was synthesized that enclosed in {111} surfaces: Single‐crystalline octahedra, single‐crystalline AuPd core–shell and twinned icosahedra. Next, various {100}‐terminated...
Fracture-free and conformal Pd–[email protected] core–shell metal–organic framework material is synthesized by a surfactant-mediated method. The hierarchical nanoporous exhibits great size-selective hydrogenation catalysis demonstrates potentials for many different applications. As service to our authors readers, this journal provides supporting information supplied the authors. Such materials are peer reviewed may be re-organized online delivery, but not copy-edited or typeset. Technical...
Therapeutic enzymes used for genetic disorders or metabolic diseases oftentimes suffer from suboptimal pharmacokinetics and stability. Nanodelivery systems have shown considerable promise improving the performance of enzyme therapies. Here, we develop a cell membrane-camouflaged metal-organic framework (MOF) system with enhanced biocompatibility functionality. The MOF core can efficiently encapsulate while maintaining their bioactivity. After introduction natural membrane coatings, resulting...
Abstract Blood transfusion is oftentimes required for patients suffering from acute trauma or undergoing surgical procedures in order to help maintain the body's oxygen levels. The continued demand worldwide blood products expected put significant strain on available resources and infrastructure. Unfortunately, efforts develop viable alternatives human red cells are generally unsuccessful. Here, a hybrid natural–synthetic nanodelivery platform that combines biocompatibility of natural RBC...
The increasing popularity of biomimetic design principles in nanomedicine has led to therapeutic platforms with enhanced performance and biocompatibility. This includes the use naturally derived cell membranes, which can bestow nanocarriers cell-specific functionalities. Herein, we report on a strategy enabling efficient encapsulation drugs via remote loading into membrane vesicles from red blood cells. is accomplished by supplementing additional cholesterol, stabilizing nanostructure...
Active transport of gas molecules is critical to preserve the physiological functions organisms. Oxygen, as most essential molecule, plays significant roles in maintaining metabolism and viability cells. Herein, we report a nanomotor-based delivery system that combines fast propulsion acoustically propelled gold nanowire nanomotors (AuNW) with high oxygen carrying capacity red blood cell membrane-cloaked perfluorocarbon nanoemulsions (RBC-PFC) for active intracellular oxygen. The kinetics...
The lack of pharmaceutical antidotes for deadly toxicants has motivated tremendous research interests in seeking synthetic nanoscavengers to absorb and neutralize harmful biological or chemical agents. Herein, we report a cell-membrane-cloaked oil nanosponge formulation capable dual-modal detoxification. biomimetic consists an olive nanodroplet wrapped by red blood cell membrane. In such construct, the core can nonspecifically soak up through physical partition membrane shell specifically...
The dipole polarizabilities, moments, density of states, and second-order nonlinear optical (NLO) properties organoimido derivatives hexamolybdates have been investigated by using time-dependent functional response theory. This class organic−inorganic hybrid compounds possesses remarkably large eye-catching molecular NLO response, especially [Mo6O17(NC16H12NO2)(FeNC10H9)]2− (7) [Mo6O17(NC16H12NO2)(NC6H2(NH2)3)]2− (6) with static polarizability (βvec) computed to be 15766.27 × 10−30 esu...
The recent emergence of biomimetic nanotechnology has facilitated the development next-generation nanodelivery systems capable enhanced biointerfacing. In particular, direct use natural cell membranes can enable multivalent targeting functionalities. Herein, we report on remote loading small molecule therapeutics into cholesterol-enriched platelet membrane-derived vesicles for disease-targeted delivery. Using this approach, high yields two model drugs, doxorubicin and vancomycin, are...
Abstract Polymeric nanoparticles coated with membrane of intact red blood cells have emerged as biomimetic toxin nanosponges (RBC‐NS) that absorb and neutralize bacterial virulence factors associated numerous infections. Despite its promise, a clear correlation between in vitro neutralization complex toxins vivo therapeutic efficacy remains elusive. In this study, the whole secreted proteins (wSP) methicillin‐resistant Staphylococcus aureus (MRSA) are collected to induce lethality mice. The...
A double-solvent mediated overgrowth method is developed to form cavities in single-crystalline MOF microcrystals. Due the different solvent effects, hollow structures are created.
The reduction of CO2 mediated by transition metals has garnered significant interest, yet little is known about the using f-element compounds. Herein, to CO tetravalent uranium (UIV) compound UO2 investigated via matrix isolation infrared spectroscopy and quantum chemical study. Our results reveal that a stable carbonate intermediate OUIVCO3 (A) can be prepared at low temperatures (4-12 K). Through photolytic reactions A under visible-light irradiations (495 nm < λ 580 nm), charge-separated...
Particulate therapeutics fabricated from polymeric materials have become increasingly popular over the past several decades. Generally, systems are easy to synthesize and tunable parameters, giving them significant potential for wide use in clinic. They come many different forms, including nanoparticles, microparticles, colloidal gels. Here, current preparation methods each type of platform discussed, along with some representative applications. To achieve enhanced performance, lipid...
Abstract The structural properties of loess are susceptible to change when subjected external loads and complex environments, leading various geological disasters. To investigate the mechanical behavior strengthening mechanism stabilized with biopolymers such as xanthan gum guar gum, especially for soils low bearing capacity stability in engineering applications, we conducted research on improvement soil tests including unconfined compressive strength, disintegration, direct shear,...
The static first hyperpolarizabilities and origin of nonlinear optical (NLO) properties [(2-methylnaphthyl)imido]hexamolybdates derivatives have been investigated by density functional theory (DFT). [(2-methylnaphthyl)imido]hexamolybdate has considerable large hyperpolarizability, 6.780 × 10−30 esu, it is larger than that [(2,6-dimethylphenyl)arylimido]hexamolybdate due to the double aromatic rings in naphthylimido ligand. ligand acts as an electron-donor polyanion electron-acceptor....