A5017651819- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Advanced Drug Delivery Systems
- Antimicrobial Peptides and Activities
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Biochemical and Structural Characterization
- Lipid Membrane Structure and Behavior
- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Drug Solubulity and Delivery Systems
- Nicotinic Acetylcholine Receptors Study
- Chemical Synthesis and Analysis
- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Advancements in Transdermal Drug Delivery
- Hemoglobin structure and function
- Liver Disease Diagnosis and Treatment
- Click Chemistry and Applications
- Cancer-related Molecular Pathways
- Ocular Surface and Contact Lens
Fudan University
2016-2025
Quzhou University
2025
Shanghai University
2022-2024
Shanghai Zhangjiang Laboratory
2024
Huashan Hospital
2018-2023
Zhongshan Hospital
2005-2022
Minhang District Central Hospital
2017-2022
State Key Laboratory of Medical Neurobiology
2018-2022
Ministry of Education of the People's Republic of China
2013
Chinese People's Liberation Army
2013
The safe and efficient delivery of chemotherapeutic agents remains critical to anticancer therapy. Herein, we report on a targeted drug system based upon modified cell membrane coating technique nanocrystals (NCs). Specifically, red blood (RBC) was with targeting peptides through facile insertion method involving avidin–biotin interactions. RBC membrane-coated NCs (RBC-NCs) exhibited high loading, long-term stability, excellent biocompatibility, prolonged retention time, all which make them...
RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these without the need for direct chemical conjugation. Insertion of both folate and nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines.
Abstract Protein corona presents a major obstacle to bench-to-bedside translation of targeted drug delivery systems, severely affecting targeting yields and directing unfavorable biodistribution. Corona-mediated provides new impetus for specific by precisely manipulating interaction modes functional plasma proteins on nano-surface. Here bio-inspired liposomes (SP-sLip) were developed modifying liposomal surface with short nontoxic peptide derived from Aβ 1-42 that specifically interacts the...
Abstract Patients with advanced melanoma that is of low tumor‐associated antigen (TAA) expression often respond poorly to PD‐1/PD‐L1 blockade therapy. Epigenetic modulators, such as hypomethylation agents (HMAs), can enhance the antitumor immune response by inducing TAA expression. Here, a dual bioresponsive gel depot acidic pH and reactive oxygen species (ROS) within tumor microenvironment (TME) for codelivery anti‐PD1 antibody (aPD1) Zebularine (Zeb), an HMA, engineered. aPD1 first loaded...
The oncoproteins MDM2 and MDMX negatively regulate the activity stability of tumor suppressor protein p53, conferring development survival. Antagonists targeting p53-binding domains kill cells both in vitro vivo by reactivating p53 pathway, promising a class antitumor agents for cancer therapy. Aided native chemical ligation mirror image phage display, we recently identified D-peptide inhibitor p53-MDM2 interaction termed D PMI-α (TNWYANLEKLLR) that competes with binding at an affinity 219...
Defensins constitute a major class of cationic antimicrobial peptides in mammals and vertebrates, acting as effectors innate immunity against infectious microorganisms. It is generally accepted that defensins are bactericidal by disrupting the anionic microbial membrane. Here, we provide evidence membrane activity human α‐defensins does not correlate with antibacterial killing. We further show α‐defensin neutrophil peptide‐1 (HNP1) binds to cell wall precursor lipid II reduction levels...
Surgical resection is a mainstay of brain tumor treatments. However, the completed excision malignant challenged by its infiltrative nature. Contrast enhanced magnetic resonance imaging widely used for defining in clinic. However ability visualization hindered transient circulation lifetime, nontargeting specificity, and poor blood barrier (BBB) permeability commercially available MR contrast agents. In this work, we developed two-order targeted nanoprobe which MR/optical reporters,...
Abstract Lysosomes of brain capillary endothelial cells are implicated in nicotine acetylcholine receptor (nAChR)‐mediated transcytosis and act as an enzymatic barrier for the transport peptide ligands to brain. A D ‐peptide ligand nAChRs (termed CDX), which binds with IC 50 value 84.5 n M , was developed by retro–inverso isomerization. CDX displayed exceptional stability lysosomal homogenate serum, demonstrated significantly higher efficiency vitro blood–brain monolayer compared parent L...
Organophosphate poisoning is highly lethal as organophosphates, which are commonly found in insecticides and nerve agents, cause irreversible phosphorylation inactivation of acetylcholinesterase (AChE), leading to neuromuscular disorders via accumulation acetylcholine the body. Direct interception organophosphates systemic circulation thus provides a desirable strategy treatment condition. Inspired by presence AChE on red blood cell (RBC) membranes, we explored biomimetic nanoparticle...
Inspired by the knowledge that most antibodies recognize a conformational epitope because of epitope's specific three-dimensional shape rather than its linear structure, we combined scaffold-based peptide design and surface molecular imprinting to fabricate novel nanocarrier harboring stable binding sites captures membrane protein. In this study, disulfide-linked α-helix-containing peptide, apamin, was used mimic extracellular, structured N-terminal part protein p32 then serve as an template...
Candid candoxin: A 16-residue peptide (CDX) that is derived from candoxin binds with a high affinity to nicotinic acetylcholine receptors (see picture), which are highly expressed on the blood–brain barrier. In vivo biodistribution and anti-glioblastoma effect indicate potential of CDX as ligand enable brain-targeted drug delivery.
A hybrid nanomaterial integrating unique toxin-absorbing nanosponges with hydrogel is developed for local antivirulence therapy against methicillin-resistant Staphylococcus aureus (MRSA) infection. The composition optimized to retain toxin after administration while not compromising transport into the gel neutralization. Mice treated nanosponge–hydrogel show markedly reduced MRSA skin lesion development.
Targeting ligands are anticipated to facilitate the precise delivery of therapeutic agents diseased tissues; however, they may also severely affect interaction nanocarriers with plasma proteins. Here, we study immunocompatibility brain-targeted liposomes, which inversely correlates absorbed natural IgM. Modification long, stable positively charged peptide on liposomes is inclined absorb IgM, leading rapid clearance and enhanced immunogenicity. Small peptidomimetic D8 developed by...