A5076461726- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Wound Healing and Treatments
- Advanced biosensing and bioanalysis techniques
- Plant nutrient uptake and metabolism
- Plant Stress Responses and Tolerance
- Electrospun Nanofibers in Biomedical Applications
- Advanced Sensor and Energy Harvesting Materials
- Liver Disease Diagnosis and Treatment
- Potato Plant Research
- Advancements in Photolithography Techniques
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Sulfur Compounds in Biology
- Graphene and Nanomaterials Applications
- Industrial Vision Systems and Defect Detection
- Advanced Nanomaterials in Catalysis
- Electron and X-Ray Spectroscopy Techniques
- Nerve injury and regeneration
- Conducting polymers and applications
- Phagocytosis and Immune Regulation
- interferon and immune responses
- MicroRNA in disease regulation
- Photosynthetic Processes and Mechanisms
Sichuan Agricultural University
2015-2025
Army Medical University
2017-2025
Southwest Hospital
2021-2025
Nanjing Medical University
2024-2025
Fudan University
2015-2024
Wuhan University
2024
Jiangsu Academy of Agricultural Sciences
2024
Shanghai University of Traditional Chinese Medicine
2019-2024
Xi'an Jiaotong University
2024
Yiwu Science and Technology Research Institute
2024
Various delivery vectors have been integrated within biologically derived membrane systems to extend their residential time and reduce reticuloendothelial system (RES) clearance during systemic circulation. However, rational design is still needed further improve the in situ penetration efficiency of chemo-drug-loaded delivery-system formulations release profiles at tumor site. Here, a macrophage-membrane-coated nanoparticle developed for tumor-targeted chemotherapy with controlled profile...
Abstract Patients with advanced melanoma that is of low tumor‐associated antigen (TAA) expression often respond poorly to PD‐1/PD‐L1 blockade therapy. Epigenetic modulators, such as hypomethylation agents (HMAs), can enhance the antitumor immune response by inducing TAA expression. Here, a dual bioresponsive gel depot acidic pH and reactive oxygen species (ROS) within tumor microenvironment (TME) for codelivery anti‐PD1 antibody (aPD1) Zebularine (Zeb), an HMA, engineered. aPD1 first loaded...
Abstract Engineering therapeutic angiogenesis in impaired tissues is critical for chronic wound healing. Materials can be engineered to deliver specific biological cues that enhance angiogenesis. However, currently available materials have limitations use engineering since the complex inflammation environment of wounds requires spatiotemporal control. Immune cells are central component microenvironment and orchestrate immune responses This study presents a novel approach using delivery...
Excessive production of inflammatory chemokines and reactive oxygen species (ROS) can cause a feedback cycle inflammation response that has negative effect on cutaneous wound healing. The use wound-dressing materials simultaneously absorb scavenge ROS constitutes novel 'weeding uprooting' treatment strategy for conditions. In the present study, composite hydrogel comprising an amine-functionalized star-shaped polyethylene glycol (starPEG) heparin chemokine sequestration as well Cu5.4O...
Excessive extracellular matrix deposition drives fibroblasts into a state of high mechanical stress, exacerbating pathological fibrosis and hypertrophic scar formation, leading to tissue dysfunction. This study reports minimally invasive convenient approach obtaining scarless using silk fibroin microneedle patch (SF MNs). We found that by tuning the MN size density only, biocompatible MNs significantly decreased elevation index in rabbit ear model increased ultimate tensile strength close...
Reperfusion injury exists as the major obstacle to full recovery of neuron functions after ischemic stroke onset and clinical thrombolytic therapies. Complex cellular cascades including oxidative stress, neuroinflammation, brain vascular impairment occur within neurovascular units, leading microthrombus formation ultimate death. In this work, a multitarget micelle system is developed simultaneously modulate various cell types involved in these events. Briefly, rapamycin encapsulated...
Current strategies for Alzheimer's disease (AD) treatments focus on pathologies in the late stage of progression. Poor clinical outcomes are displayed due to irreversible damages caused by early microglia abnormality which triggers development before identical symptoms emerge. Based crosstalk between and brain microenvironment, a reactive oxygen species (ROS)-responsive polymeric micelle system (Ab-PEG-LysB/curcumin (APLB/CUR)) is reported normalize oxidative inflammatory microenvironment...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most intractable malignancy, with an only 6% 5-year relative survival rate. The dismal therapeutic effect attributed to chemotherapy resistance and unique pathophysiology abundant inflammatory cytokines abnormal hyperplasia extracellular matrix (ECM). Based on theory that bone marrow mesenchymal stem cells (BM-MSCs) can influence tumorous microenvironment malignant growth PDAC, we employed exosomes (Exos) derived from BM-MSCs as...
The blood–brain barrier (BBB) and the poor ability of many drugs to cross that greatly limits efficacy chemotherapies for glioblastoma multiforme (GBM). present study exploits albumin as drug delivery vehicle promote chemotherapeutic paclitaxel (PTX) by improving stability targeting efficiency PTX/albumin nanoparticles (NPs). Here we characterize PTX-loaded human serum (HSA) NPs stabilized with intramolecular disulfide bonds modified substance P (SP) peptide ligand. fabricated SP-HSA-PTX...
Anticancer therapies, which can induce cell death and elevate antitumor immune response in the meantime, are considered as effective treatments for many types of cancers. Immunogenic (ICD) induced by chemodrugs is a promising typical strategy to achieve cytotoxicity immunological enhancement together. However, due low level ICD induction less tumor-targeting accumulation, application traditional inducers limited. Here, core-shell magnetic nanoparticles (ETP-PtFeNP:α-enolase targeting peptide...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive malignancy with a five year survival rate of <5%. The aberrant expression extracellular matrix (ECM) in tumor stroma forms compact physical barrier, which that leads to insufficient extravasation and penetration nanosized therapies. To overcome severe resistance PDAC conventional therapies, sequentially triggered nanoparticle (aptamer/cell‐penetrating peptide‐camptothecin prodrug, i.e., Apt/CPP‐CPTD NPs) intelligent...
Glioma is regarded as the deadliest and most common brain tumor because of extremely difficult surgical excision ascribed from its invasive nature. In addition, natural blood-brain barrier (BBB) greatly restricts therapeutics' penetration into central nervous system. Carmustine (BCNU) a widely used antiglioma drug in clinical applications. However, serious complications prevent it being applied setting to some extent. Thus, urgent explore novel BCNU delivery systems specially designed for...
Pancreatic ductal adenocarcinoma (PDAC) is considered as one of the most aggressive malignancies due to its unique microenvironment which cardinal histopathological feature remarkable desmoplasia stroma, taking up about 80% tumor mass. The desmoplastic stroma negatively affects drug diffusion and infiltration T cells, leading an immunosuppressive microenvironment. However, this can limit physical spread pancreatic cancer via a neighbor suppression effect. Here, central targeting responsive...