A5028289642- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Quantum Computing Algorithms and Architecture
- Advanced biosensing and bioanalysis techniques
- Quantum Information and Cryptography
- Black Holes and Theoretical Physics
- Machine Learning and ELM
- Cosmology and Gravitation Theories
- Domain Adaptation and Few-Shot Learning
- Vector-borne infectious diseases
- Dendrimers and Hyperbranched Polymers
- Immunotherapy and Immune Responses
- Alzheimer's disease research and treatments
- HIV Research and Treatment
- Machine Learning in Materials Science
- Advanced Neural Network Applications
- Astrophysical Phenomena and Observations
- S100 Proteins and Annexins
- Immune cells in cancer
- HIV/AIDS Research and Interventions
- Neurological Disease Mechanisms and Treatments
- Genetic and phenotypic traits in livestock
- Protein Interaction Studies and Fluorescence Analysis
- Quantum-Dot Cellular Automata
Wuzhou University
2024
Ministry of Education of the People's Republic of China
2023
Sichuan University
2018-2023
University of Electronic Science and Technology of China
2019-2023
Shaanxi University of Science and Technology
2022-2023
Soochow University
2021-2022
Guangzhou University of Chinese Medicine
2022
Fudan University
2009-2021
The University of Texas Medical Branch at Galveston
2017-2021
Boston Children's Museum
2020
To understand the high variability of asymptomatic interval between primary human immunodeficiency virus type 1 (HIV-1) infection and development AIDS, we studied evolution C2-V5 region HIV-1 env gene T-cell subsets in nine men with a moderate or slow rate disease progression. They were monitored from time seroconversion for period 6 to 12 years until advanced seven men. Based on analysis viral divergence founder strain, population diversity within sequential points, outgrowth viruses...
Various delivery vectors have been integrated within biologically derived membrane systems to extend their residential time and reduce reticuloendothelial system (RES) clearance during systemic circulation. However, rational design is still needed further improve the in situ penetration efficiency of chemo-drug-loaded delivery-system formulations release profiles at tumor site. Here, a macrophage-membrane-coated nanoparticle developed for tumor-targeted chemotherapy with controlled profile...
Encapsulation of small-molecule drugs in hydrophobic polymers or amphiphilic copolymers has been extensively used for preparing polymeric nanoparticles (NPs). The loadings and loading efficiencies a wide range NPs, however, tend to be very low. In this Communication, we report strategy prepare NPs with exceptionally high drug (>50%) quantitative efficiency. Specifically, dimeric conjugate bearing trigger-responsive domain was designed as the core-constructing unit NPs. Upon co-precipitation...
The extracellular (interstitial) pH (pHe) of solid tumours is significantly more acidic compared to normal tissues. In-vitro, low reduces the uptake weakly basic chemotherapeutic drugs and, hence, their cytotoxicity. This phenomenon has been postulated contribute a 'physiological' resistance in vivo. Doxorubicin weak base agent that commonly used combination chemotherapy clinically treat breast cancers. report demonstrates MCF-7 human cancer cells vitro are susceptible doxorubicin toxicity...
Current strategies for Alzheimer's disease (AD) treatments focus on pathologies in the late stage of progression. Poor clinical outcomes are displayed due to irreversible damages caused by early microglia abnormality which triggers development before identical symptoms emerge. Based crosstalk between and brain microenvironment, a reactive oxygen species (ROS)-responsive polymeric micelle system (Ab-PEG-LysB/curcumin (APLB/CUR)) is reported normalize oxidative inflammatory microenvironment...
The blood–brain barrier (BBB) and the poor ability of many drugs to cross that greatly limits efficacy chemotherapies for glioblastoma multiforme (GBM). present study exploits albumin as drug delivery vehicle promote chemotherapeutic paclitaxel (PTX) by improving stability targeting efficiency PTX/albumin nanoparticles (NPs). Here we characterize PTX-loaded human serum (HSA) NPs stabilized with intramolecular disulfide bonds modified substance P (SP) peptide ligand. fabricated SP-HSA-PTX...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive malignancy with a five year survival rate of <5%. The aberrant expression extracellular matrix (ECM) in tumor stroma forms compact physical barrier, which that leads to insufficient extravasation and penetration nanosized therapies. To overcome severe resistance PDAC conventional therapies, sequentially triggered nanoparticle (aptamer/cell‐penetrating peptide‐camptothecin prodrug, i.e., Apt/CPP‐CPTD NPs) intelligent...
Glioma is regarded as the deadliest and most common brain tumor because of extremely difficult surgical excision ascribed from its invasive nature. In addition, natural blood-brain barrier (BBB) greatly restricts therapeutics' penetration into central nervous system. Carmustine (BCNU) a widely used antiglioma drug in clinical applications. However, serious complications prevent it being applied setting to some extent. Thus, urgent explore novel BCNU delivery systems specially designed for...
Triple-negative breast cancers (TNBCs), devoid of hormone receptors and human epidermal growth-factor receptor-2/Neu expression, bring about poor prognosis induce a high rate systematic metastases. The ineffectiveness current therapies on TNBCs could be attributed to the lack efficient targeted therapy. Paclitaxel (PTX) is considered one first-line chemotherapeutics for TNBC treatment but, due its low aqueous solubility nonspecific accumulation, results in antitumor efficacy. present study...
Tumor-associated macrophages (TAMs) constitute over 50% of the number cells within tumor, playing a major role in tumor progression and invasion. Remodeling immune microenvironment by modulating TAM polarization has been emerging as new promising therapeutic strategy. However, high interstitial fluid pressure dense extracellular matrix lead to insufficient penetration nanosized therapies. To overcome this dilemma, an acid-triggered size-changeable nanoparticle (aptamer/acid sensitive linker...
In clinical therapy, the poor prognosis of hepatocellular carcinoma (HCC) is mainly attributed to failure chemotherapeutical agents accumulate in tumor as well their serious systemic toxicity. this work, we developed actively tumor-targeting trilayer micelles with microenvironment-sensitive cross-links a novel nanocarrier for HCC therapy. These comprised biodegradable PEG-pLys-pPhe polymers, which pLys could react disulfide-containing agent form redox-responsive cross-links. vitro drug...
The activation of caspase-3 is an important hallmark in Parkinson's disease. It could induce neuron death by apoptosis and microglia inflammation. As a result, inhibition the would exert synergistic dual effect brain order to prevent progress Silencing genes RNA interference inhibit caspase-3. We developed brain-targeted gene delivery system based on non-viral vector, dendrigraft poly-L-lysines. A rabies virus glycoprotein peptide with 29 amino-acid linked poly-L-lysines render vectors...
Ligand-mediated polymeric micelles have enormous potential for improving the efficacy of glioma therapy. Linear–dendritic drug–polymer conjugates composed doxorubicin (DOX) and polyethylene glycol (PEG) were synthesized with or without modification choline derivate (CD). The resulting MeO–PEG–DOX8 CD–PEG–DOX8 could self-assemble into a nanosized diameter around 30 nm high drug loading content up to 40.6 32.3%, respectively. optimized formulation 20% had superior cellular uptake antitumor...
Tumor microenvironment plays a vital role in the process of tumor development, proliferation, invasion, and metastasis. It is well acknowledged that reduction pH, reactive oxygen species (ROS), increased level glucose transporter 1 (GLUT1) have become featured intracellular extracellular biochemical markers cancer owing to oncogenic transformation abnormal metabolism. To establish distinctive drug delivery system directed against features, we develop newly engineered polymeric nanoplatform...
An ideal gene-carrying vector is supposed to exhibit outstanding gene-condensing capability with positively charged macromolecules protect the carried gene during in vivo circulation and a rapid dissociation upon microenvironmental stimuli at aimed sites release escorted gene. Currently, it still remains challenge develop an carrier efficient transfection ability low toxicity for clinical applications. Herein, we have innovatively introduced reactive oxygen species (ROS)-biodegradable boric...
Pseudomonas aeruginosa is an opportunistic and nosocomial pathogen of humans with hundreds its virulence factors regulated by quorum sensing (QS) system. Small noncoding RNAs (sRNAs) are also key regulators bacterial virulence. However, the QS regulatory sRNAs (Qrrs) that have been characterized in P. still largely unknown. Here, sRNA AmiL (PA3366.1) amiEBCRS operon PAO1 was identified as a novel Qrr transcriptome sequencing (RNA-Seq). The expression negatively las or rhl system, which RhlR...
Efficient drug accumulation in tumor cells is essential for cancer therapy. Herein, we developed dimeric prodrug self-delivery nanoparticles (NPs) with enhanced loading and bioreduction responsiveness triple negative breast (TNBC) Specially designed camptothecin (CPTD) containing a disulfide bond was constructed to realize intracellular redox potential controlled release. Direct conjugation of hydrophobic CPTD poly(ethylene glycol) PEG5000, prodrug-based amphiphilic CPTD–PEG5000 co-polymer...
The hybrid architecture of convolutional neural networks (CNNs) and Transformer are very popular for medical image segmentation. However, it suffers from two challenges. First, although a CNNs branch can capture the local features using vanilla convolution, cannot achieve adaptive feature learning. Second, global features, ignores channel cross-dimensional self-attention, resulting in low segmentation accuracy on complex-content images. To address these challenges, we propose novel hand with...
We study the dynamics of domain walls formed through spontaneous breaking an approximate $\mathbb{Z}_2$ symmetry in a scalar field, focusing on their collapse under influence quantum and thermal corrections induced by $\mathbb{Z}_2$-violating Yukawa coupling to Dirac fermions bath. The effects render potential bias between true false vacua temperature-dependent may lead notable variations annihilation temperature walls, addition shift caused temperature-independent corrections. These...
ABSTRACT Although human immunodeficiency virus type 1 (HIV-1) recombinants have been found with high frequency, little is known about the forces that select for these viruses or their importance to pathogenesis. Here we document emergence and dynamics of 11 distinct HIV-1 in a man who was infected two subtype B strains progressed rapidly AIDS without developing substantial cellular humoral immune responses. numerous frequency oscillations were observed, single recombinant lineage eventually...