A5040179504- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Microfluidic and Bio-sensing Technologies
- Cancer Immunotherapy and Biomarkers
- Microbial Inactivation Methods
- interferon and immune responses
- Graphene and Nanomaterials Applications
- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Ion channel regulation and function
- 3D Printing in Biomedical Research
- NF-κB Signaling Pathways
- Conducting polymers and applications
- Circular RNAs in diseases
- Bone Tissue Engineering Materials
- Cardiac Ischemia and Reperfusion
- Neonatal Respiratory Health Research
- Ubiquitin and proteasome pathways
- Virus-based gene therapy research
- Microfluidic and Capillary Electrophoresis Applications
Jilin University
2013-2025
Guangxi Medical University
2024
China Rehabilitation Research Center
2024
Capital Medical University
2024
The University of Texas Southwestern Medical Center
2019-2023
The University of Texas MD Anderson Cancer Center
2010-2023
Mayo Clinic
2021-2023
Jilin Medical University
2023
The Ohio State University
2013-2022
Southwestern Medical Center
2020
Tumour cell phagocytosis by antigen presenting cells (APCs) is critical to the generation of antitumour immunity. However, cancer can evade upregulating anti-phagocytosis molecule CD47. Here, we show that CD47 blockade alone inefficient in stimulating glioma phagocytosis. combining with temozolomide results a significant pro-phagocytosis effect due latter's ability induce endoplasmic reticulum stress response. Increased tumour subsequently enhances cross-presentation and activation cyclic...
Abstract The recent success of mRNA therapeutics against pathogenic infections has increased interest in their use for other human diseases including cancer. However, the precise delivery genetic cargo to cells and tissues remains challenging. Here, we show an adaptive strategy that enables docking different targeting ligands onto surface mRNA-loaded small extracellular vesicles (sEVs). This is achieved by using a microfluidic electroporation approach which combination nano- milli-second...
The limitations of conventional cancer treatment are driving the emergence and development nanomedicines. Research in liposomal nanomedicine for therapy is rapidly increasing, opening up new horizons treatment. Liposomal nanomedicine, which focuses on targeted drug delivery to improve therapeutic effect while reducing damage normal tissues cells, has great potential field therapy. This review aims clarify advantages systems We describe recent understanding spatiotemporal fate liposomes...
Polylactic acid (PLA) is widely used in biological areas due to its excellent compatibility, bioabsorbability, and degradation behavior human bodies. Pure polylactic has difficulty meeting all the requirements that specific field may demand. Therefore, PLA based nanocomposites are extensively investigated over past few decades. include copolymers nanometer size with or as matrix nanofillers annexing agent. The small scale effect surface of nanomaterials help improve properties make more...
Abstract Sub-wavelength antireflection moth-eye structures were fabricated with Nickel mold using Roll-to-Plate (R2P) ultraviolet nanoimprint lithography (UV-NIL) on transparent polycarbonate (PC) substrates. Samples well replicated patterns established an average reflection of 1.21% in the visible light range, 380 to 760 nm, at normal incidence. An excellent property a wide range incidence angles was shown below 4% 50°. Compared unpatterned ultraviolet-curable resin coating, resulting...
Abstract A major challenge in the development of cancer nanomedicine is inability for nanomaterials to efficiently penetrate and deliver therapeutic agents into solid tumors. Previous studies have shown that tumor vasculature extracellular matrix regulate transvascular interstitial transport nanoparticles, both critical successfully delivering Within malignant microenvironment, blood vessels are morphologically abnormal functionally exhibit substantial permeability. Furthermore, (ECM),...
Of great interest to modern medicine and biomedical research is the ability inject individual target cells with desired genes or drug molecules. Some advances in cell electroporation allow for high throughput, viability, excellent dosage control, yet no platform available combination of all three. In an effort solve this problem, here we show a "3D nano-channel (NEP) chip" on silicon designed meet these three criteria. This NEP chip can simultaneously deliver molecules into 40 000 per cm2...
Current transfection technologies lead to significant inter-clonal variations. Previously we introduced a unique electrotransfection technology, Nanochannel-Electroporation (NEP), which can precisely and benignly transfect small cell populations (~100-200 cells) with single-cell resolution. Here report on the development of novel 3D NEP system for large scale transfection. A properly-engineered array nanochannels, capable handling/transfecting ~60 000 cells cm(-2), was fabricated using...
Carbon nanotubes (CNTs), one of the unique one-dimensional nanomaterials, have gained great attention because their specific characters, versatile functionalization chemistry, and biological compatibility in past few decades. CNTs can be functionalized via different methods to perform functions. been used various areas biomedicine as nanocarriers, including cancer diagnosis therapy. Different molecules such peptide, antigen, nucleic acid delivered cells by with high efficiency. In this...
(1) Purpose: To improve the capability of EfficientNet, including developing a cropping method called Random Center Cropping (RCC) to retain original image resolution and significant features on images’ center area, reducing downsampling scale EfficientNet facilitate small images RPCam datasets, integrating attention Feature Fusion (FF) mechanisms with obtain containing rich semantic information. (2) Methods: We adopt Convolutional Neural Network (CNN) detect classify lymph node metastasis...
Injection molding technology has been in development for almost 150 years.Injection is a that melts the material with aid of screw and an external heating device then injects it into mold to form corresponding product as cools.At present, many types materials can be used products by injection molding.Many requirements problems processing different have also caursed birth processes.At applied fields, from daily necessities are closely related our lives parts components aerospace field.At...