A5024887366- Micro and Nano Robotics
- Material Dynamics and Properties
- Pickering emulsions and particle stabilization
- RNA Interference and Gene Delivery
- Lipid metabolism and biosynthesis
- Microfluidic and Bio-sensing Technologies
- Polymer crystallization and properties
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Advanced biosensing and bioanalysis techniques
- Advanced Thermodynamics and Statistical Mechanics
- Nanoplatforms for cancer theranostics
- Phase Equilibria and Thermodynamics
- Supercapacitor Materials and Fabrication
- MicroRNA in disease regulation
- Dendrimers and Hyperbranched Polymers
- Nitrogen and Sulfur Effects on Brassica
- Peroxisome Proliferator-Activated Receptors
- Polymer Surface Interaction Studies
- Conducting polymers and applications
- Modular Robots and Swarm Intelligence
- Ion channel regulation and function
- Radioactive element chemistry and processing
- Perovskite Materials and Applications
- Advancements in Battery Materials
Soochow University
2016-2025
Huazhong University of Science and Technology
2007-2025
Wuhan Third Hospital
2025
Shanghai Institute of Applied Physics
2024
Shanghai University
2023-2024
Chinese Academy of Sciences
2012-2024
Marine Design & Research Institute of China
2023-2024
University of Science and Technology of China
2024
Hefei Institutes of Physical Science
2024
Institute of Intelligent Machines
2024
To date, the in vivo imaging of quantum dots (QDs) has been mostly qualitative or semiquantitative. The development a dual-function PET/near-infrared fluorescence (NIRF) probe can allow for accurate assessment pharmacokinetics and tumor-targeting efficacy QDs.A QD with an amine-functionalized surface was modified RGD peptides 1,4,7,10-tetraazacyclodocecane-N,N',N'',N'''-tetraacetic acid (DOTA) chelators integrin alpha(v)beta(3)-targeted PET/NIRF imaging. A cell-binding assay cell staining...
Integrin alpha(v)beta(3) plays a critical role in tumor angiogenesis and metastasis. Suitably radiolabeled cyclic arginine-glycine-aspartic (RGD) peptides can be used for noninvasive imaging of expression targeted radionuclide therapy. In this study, we developed (64)Cu-labeled multimeric RGD peptides, E{E[c(RGDyK)](2)}(2) (RGD tetramer) E(E{E[c(RGDyK)](2)}(2))(2) octamer), PET integrin expression.Both tetramer octamer were synthesized with glutamate as the linker. After conjugation...
Real-time quantitative PCR was used to study lipoxygenase (LOX) gene expression patterns in kiwifruit (Actinidia deliciosa [A. Chev.] C.F. Liang et A.R. Ferguson var. cv. Hayward) during fruit ripening, and response ethylene low temperature post-harvest storage. Six LOX genes were identified cloned from a EST database. All expressed vegetative tissues the fruit. Expression of AdLox1 AdLox5 increased markedly as developed climacteric stage up-regulated by treatment, following similar pattern...
Antiosteoporosis gene-based drug development strategies are presently focused on targeting osteoblasts to either suppress bone loss or increase mass. Although siRNA/microRNA-based gene therapy has enormous potential, it is severely limited by the lack of specific cell-targeting delivery systems. We report an osteoblast-targeting peptide (SDSSD) that selectively binds via periostin. developed SDSSD-modified polyurethane (PU) nanomicelles encapsulating siRNA/microRNA delivers drugs...
The nonlinear Langevin equation theory of segmental relaxation, elasticity, and mechanical response deformed polymer glasses with aging rejuvenation processes taken into account is applied to study material under a constant strain rate deformation. In the postyield softening regime, amplitude stress overshoot feature, its breadth in strain, are predicted be positively correlated mechanically induced disordering process. key physics increase density fluctuation due generated disorder...
Lycopene β-cyclase (LCYB) is an essential enzyme that catalyzes the conversion of lycopene into α-carotene and β-carotene in carotenoid biosynthesis pathway. However, roles underlying mechanisms LCYB gene plant responses to abiotic stresses are rarely known. This has not been used improve contents sweetpotato, Ipomoea batatas (L.) Lam.. In present study, a new allele gene, named IbLCYB2, was isolated from storage roots sweetpotato line HVB-3. Its overexpression significantly increased...
Tin dioxide (SnO2) has been widely applied as an electron transport layer (ETL) for the n-i-p-type perovskite solar cells (Pero-SCs). However, existence of defects at surface SnO2 and hysteresis behavior devices with ETL limit its application in Pero-SCs. In this study, a fullerene derivative pyrrolidinofullerene C60-substituted phenol (NPC60-OH) was synthesized to modify Pero-SCs first time. The systematic comparative characterizations demonstrated that, after introduction NPC60-OH...
Ultrathin two-dimensional metal-organic frameworks (MOFs) have convincing performances in energy storage, which can be put down to their accessible active sites with rapid charge transfer. Herein, NiCo-layered double hydroxide (LDH) nanosheet arrays are used as self-sacrificial templates situ fabricate ultrathin NiCo-MOF on Ni foam (NS/NF) by using organic ligands without adding metal sources. Two MOF nanosheets different ligands, terephthalate (BDC) and 2-aminoterephthalate (NH2-BDC),...
Abstract Flexible thermoelectrics, including flexible thermoelectric materials and devices, can generate electricity by utilizing the small temperature difference between human body surrounding environment, exhibiting great potential for continuous powering of wearable devices. It has long been assumed that inorganic are usually brittle at room except size‐induced flexibility. Until recently, this perception overturned discovery semiconductors with intrinsic plastic deformability. Herein,...
Amidoxime (AO)-based adsorbents are currently regarded as the most promising materials for extracting uranium (U) from seawater, but have limited adsorption capacities.
Yellow seed coat color (SCC) is a valuable trait in Brassica napus , which significantly correlated to high oil content (SOC) and low lignocellulose (SLC). However, no dominant yellow SCC genes were identified B. . In this study, N53-2 was verified, then 58,981 eQTLs 25 trans-eQTL hotspots double haploid population derived from black material Ken-C8. A rare allele DYSOC1 ( gene of improved 1 ) subsequently cloned hotspot that colocated with SCC, SOC, SLC QTL on ChrA09 through fine mapping...
In vivo imaging of α<sub>v</sub>β<sub>3</sub> expression has important diagnostic and therapeutic applications. Multimeric cyclic RGD peptides are capable improving the integrin α<sub>v</sub>β<sub>3</sub>–binding affinity due to polyvalency effect. Here we report an example <sup>18</sup>F-labeled tetrameric peptide for PET in both xenograft spontaneous tumor models. <b>Methods:</b> The E{E[c(RGDyK)]<sub>2</sub>}<sub>2</sub> was derived with amino-3,6,9-trioxaundecanoic acid (mini-PEG; PEG is...
We review recent progress in developing statistical mechanical theories for the slow activated segmental dynamics and response of deeply supercooled polymer melts glasses. The focus is polymer-based predictive approaches uniquely macromolecular aspects. summarize central concepts that underlie two prominent molten state critically discuss their key predictions confrontation with experiment. influence anisotropic conformation interchain packing on emergence glassy oriented liquid crystals...
Lipid-free apolipoprotein (apo) A-I and discoidal reconstituted high-density lipoproteins (rHDL) containing apoA-I, (A-I)rHDL, inhibit vascular inflammation by increasing 3β-hydroxysteroid-Δ24 reductase (DHCR24) expression.To determine whether the lipid-free apoA-I-mediated (A-I)rHDL-mediated increase in DHCR24 expression induces cytoprotective potentially cardioprotective enzyme, heme oxygenase-1 (HO-1).In vivo: A single intravenous infusion of apoA-I (8 mg/kg) administered 24 hours before...
Inflammatory bowel disease (IBD) such as Crohn's and ulcerative colitis is a chronic autoimmune affecting nearly five million people worldwide. Among all drug delivery system, oral administration the most preferable route for colon-specific targeting treatment of IBD. Herein, an amphiphilic curcumin polymer (PCur) composed hydrophilic poly(ethylene glycol) (PEG) hydrophobic (Cur) linked by disulfide bond was synthesized characterized. The sufficient solubility, nano-scaled size close to...
MicroRNA-21 (miR-21) is an oncomiR that frequently upregulated in human cancers. AntimiR-21 (AM-21) oligonucleotide complementary to miR-21 designed inhibit its gene silencing activities. To facilitate efficient delivery of AM-21, a novel lipid nanoparticle formulation called QTsome, based on combination quaternary amine and tertiary cationic lipids, with distinctive pH-responsive profile, was developed. QTsome/AM-21 comprising DODMA/DOTAP/DOPC/CHOL/mPEG-DPPE AM-21 exhibited mean particle...
A π-conjugated and alcohol-soluble small molecule was used to passivate defects in p–i–n Pero-SCs with a PCE of 21.40% <italic>V</italic><sub>oc</sub> 1.19 V.