A5074806342- Advanced biosensing and bioanalysis techniques
- Microfluidic and Bio-sensing Technologies
- Nanoparticle-Based Drug Delivery
- Microfluidic and Capillary Electrophoresis Applications
- RNA Interference and Gene Delivery
- Biosensors and Analytical Detection
- Graphene research and applications
- Nanopore and Nanochannel Transport Studies
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- Receptor Mechanisms and Signaling
- Single-cell and spatial transcriptomics
- Graphene and Nanomaterials Applications
- Mass Spectrometry Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Molecular Junctions and Nanostructures
- Organic Electronics and Photovoltaics
- CRISPR and Genetic Engineering
- Neuropeptides and Animal Physiology
- Photoacoustic and Ultrasonic Imaging
- Nonlinear Optical Materials Research
- MicroRNA in disease regulation
- Circadian rhythm and melatonin
- Free Radicals and Antioxidants
- HER2/EGFR in Cancer Research
The First Affiliated Hospital, Sun Yat-sen University
2025
Zhongshan Hospital
2025
Fudan University
2025
Sun Yat-sen University
2025
Columbia University
2011-2023
The University of Texas at Arlington
2022
Weifang Medical University
2021
Jiangsu Normal University
2021
The Ohio State University
2010-2020
Zhejiang Provincial People's Hospital
2019
White polymer light-emitting devices with a peak forward-viewing power efficiency close to 40 lm W−1, corresponding an external quantum of 28.8% and luminous 60 cd A−1, are demonstrated. The based on two newly synthesized yellow-emitting iridium complexes functionalized the sterically hindered diarylfluorene chromophores fabricated by simple solution-processing method.
Water-soluble Au-Fe3O4 heterostructured nanoparticles with high biocompatibility were synthesized and applied as a dual modality contrast agent. These present strong CT/MRI enhancement in rabbit model. Low concentrations of found to obtain similar effect commercial iodine agent the CT image.
High quality, large grain size graphene on polycrystalline nickel film two inch silicon wafers was successfully synthesized by the chemical vapor deposition (CVD) method. The polydimethylsiloxane (PDMS) stamping method used for transferring in this experiment. transferred onto Al2O3/ITO substrates patterned into macroscopic dimension electrodes using conventional lithography followed oxygen plasma etching. Experimental results show that can serve as transparent source and drain high...
Carbon nanotubes (CNTs), one of the unique one-dimensional nanomaterials, have gained great attention because their specific characters, versatile functionalization chemistry, and biological compatibility in past few decades. CNTs can be functionalized via different methods to perform functions. been used various areas biomedicine as nanocarriers, including cancer diagnosis therapy. Different molecules such peptide, antigen, nucleic acid delivered cells by with high efficiency. In this...
The siRNA LOR-1284 targets the R2 subunit of ribonucleotide reductase (RRM2) and has shown promise in cancer therapy. In this study, transferrin (Tf) conjugated lipid nanoparticles (Tf–NP–LOR-1284) were synthesized by microfluidic hydrodynamic focusing (MHF) evaluated for targeted delivery into acute myeloid leukemia (AML) cells. vitro study showed that Tf–NP–LOR-1284 can protect from serum nuclease degradation. Selective uptake was observed MV4-11 addition, qRT-PCR Western blot results...
Isolation of cells from heterogeneous mixtures is critically important in both basic cell biology studies and clinical diagnostics. Cell isolation can be realized based on physical properties such as size, density electrical properties. Alternatively, affinity binding target by surface-immobilized ligands, antibodies, used to achieve specific isolation. Microfluidics technology has recently been conjunction with antibody-based methods capture, purify isolate higher yield rates, better...
The hybrid platinum@iron oxide core–shell nanorods with high biocompatibility were synthesized and applied for combined therapy. These exhibit a good photothermal effect on cancer cells upon irradiation NIR laser. Furthermore, due to the presence of atomic number element (platinum core), show synergistic between radiation Therefore, as-prepared could play an important role in facilitating therapy achieve better therapeutic efficacy.
We report a facile synthesis of bifunctional Fe3O4-Ag125I heterodimers for use as dual-modality imaging agents in magnetic resonance (MR) and single-photon emission computed tomography (SPECT). introduced 125I, which is clinically used radioisotope, SPECT reporter, into Fe3O4-Ag heterodimer nanoparticles to provide new type contrast agent MRI imaging.
Poly(glycerol sebacate) (PGS), a biodegradable elastomer, has been extensively explored in biomedical applications for its favorable mechanical properties and biocompatibility. Efforts have made to fabricate multifunctional PGS copolymer recent years, particular PGS-co-PEG (poly(glycerol sebacate)-co-polyethylene glycol) polymers. However, rare research systematically conducted on the effect of reactant ratios physicochemical biocompatibility till now. In this study, serial PEGylated (PEGS)...
Nanocomposites for integrating imaging and therapy have attracted tremendous attention biomedical applications. Herein, Fe@Bi2S3 nanocomposites modified with polyethylene glycol (PEG) molecules are fabricated synergistic thermoradiotherapy. For such nanocomposites, Bi2S3 exhibits a strong absorbance in the near-infrared (NIR) region, which allows to convert energy from light into heat effective photothermal (PTT), whereas Bi can also significantly enhance radio-mediated cell death induction...
Current single-cell RNA-seq approaches are hindered by preamplification bias, loss of strand origin information, and the inability to observe small-RNA mRNA dual transcriptomes. Here, we introduce a holo-transcriptome sequencing (Holo-Seq) that overcomes all three hurdles. Holo-Seq has same quantitative accuracy uniform coverage with complete information as bulk RNA-seq. Most importantly, can simultaneously small RNAs mRNAs in single cell. Furthermore, acquire RNA transcriptomes 32 human...
In order to accurately identify the low-concentration M-spikes in serum protein electrophoresis (SPE) patterns, a new artificial intelligence (AI) system is explored. 166,003 SPE data sets, which were equally divided into 4 training sets and 1 optimal set, utilized establish evaluate AI system, namely, "AIRSPE". 10,014 internal test 1861 external with immunofixation (IFE) results as gold standard used assess performance of AIRSPE including sensitivity, negative predictive value, concordance....
With the development of nanotechnology, nanocomposites have been used as bimodal contrast agents for magnetic resonance (MR) and computed tomography (CT) imaging. We developed a facile method synthesis iron oxide@bismuth sulfide core-shell nanocomposites. These bifunctional can be made water-soluble via PEG coating present strong MRI/CT enhancement. Evaluation cytotoxicity by MTT assay shows that low cytotoxicity. The results illustrate great potential imaging MR/CT.
Gene expression analysis at the single-cell level is critical to understanding variations among cells in heterogeneous populations. Microfluidic reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) well suited gene assays of single cells. We present a microfluidic approach that integrates all functional steps for RT-qPCR cell, including isolation and lysis as purification, PCR messenger RNA cell lysate. In this approach, reactions multi-step assay lysed can be...