A5100364641- Radiomics and Machine Learning in Medical Imaging
- COVID-19 Clinical Research Studies
- Nanoplatforms for cancer theranostics
- Functional Brain Connectivity Studies
- Long-Term Effects of COVID-19
- Advanced MRI Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Nanoparticle-Based Drug Delivery
- COVID-19 diagnosis using AI
- COVID-19 and healthcare impacts
- Lung Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Multiple Sclerosis Research Studies
- MRI in cancer diagnosis
- Seismology and Earthquake Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Medical Imaging Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Computational Techniques and Applications
- Neural dynamics and brain function
- Pain Mechanisms and Treatments
- AI in cancer detection
- Pleural and Pulmonary Diseases
- Gold and Silver Nanoparticles Synthesis and Applications
Soochow University
2016-2025
First Affiliated Hospital of Soochow University
2015-2025
First People's Hospital of Yunnan Province
2023-2025
Chinese PLA General Hospital
2021-2025
Chongqing Medical University
2024
Tianjin University
2024
Children's Hospital of Chongqing Medical University
2024
Beijing HuiLongGuan Hospital
2024
Peking University
2024
Yunnan Metallurgical Group (China)
2024
Enhanced near-field at noble metal nanoparticle surfaces due to localized surface plasmon resonance (LSPR) has been researched in fields ranging from biomedical photoelectrical applications. However, it is rarely explored on nonmetallic nanomaterials discovered recent years, which can also support LSPR by doping-induced free charge carriers, let alone the investigation of an intricate system involving both. Here we construct a dual plasmonic hybrid nanosystem Au-Cu9S5 with well controlled...
It is well established that interleukin (IL)-22 has hepatoprotective and antifibrotic functions in acute liver injury models; however, its function patients with fibrosis cirrhosis (LC) remains obscure. In the current study, we demonstrated expression of numerous IL-22 pathway-associated genes was significantly up-regulated hepatitis B virus (HBV)-infected tissues, compared to normal controls, through microarray analysis. agreement these findings, liver-infiltrating IL-22(+) cells were...
Purpose: To analyze functional connectivity (FC) of the visual cortex using resting-state MRI in human primary open-angle glaucoma (POAG) patients.Materials and Methods: Twenty-two patients with known POAG 22 age-matched controls were included this IRB-approved study.Subjects evaluated by 3 T MR blood oxygenation level dependent three-dimensional brain volume imaging (3D-BRAVO) MRI.Data processing was performed standard software.FC maps generated from Brodmann areas (BA) 17/18/19/7 a...
The long-term consequences of human umbilical cord-derived mesenchymal stem cell (UC-MSC) treatment for COVID-19 patients are yet to be reported. This study assessed the 1-year outcomes in with severe COVID-19, who were recruited our previous UC-MSC clinical trial.In this prospective, longitudinal, cohort study, 100 enrolled phase 2 trial prospectively followed up at 3-month intervals 1 year evaluate safety and effectiveness treatment. primary endpoint was an altered proportion whole-lung...
BackgroundLong-term effects of human mesenchymal stem cell (MSC) treatment on COVID-19 patients have not been fully characterized. The aim this study was to evaluate the safety and efficacy a MSC administered severe enrolled in our previous randomized, double-blind, placebo-controlled clinical trial (NCT 04288102).MethodsA total 100 experiencing received either (n = 65, 4 × 107 cells per infusion) or placebo 35) combined with standard care days 0, 3, 6. Patients were subsequently evaluated...
Abstract This study aimed to investigate the topological properties of brain functional networks in patients with tinnitus varying durations. A total 51 (divided into recent‐onset (ROT) and persistent (PT) groups) 27 healthy controls (HC) were recruited. All participants underwent resting‐state MRI audiological assessments. Graph theory was used examine network topology. The results showed that ROT group exhibited lower clustering coefficient, gamma, sigma local efficiency compared both HC...
Nanoagents of integrating multiple imaging and therapeutic modalities have attracted tremendous attention for biomedical applications. Herein, we synthesize porous hollow Fe3O4 as a theranostic agent MRI combined photothermal/chemo cancer therapy. The as-prepared iron oxide nanoagents allow T2-weighted MR imaging. Interestingly, demonstrate that the structure endows an outstanding photothermal property cell killing, in comparison with other types nanomaterials. Under exposure NIR laser, heat...
PURPOSE:To predict programmed death-ligand 1 (PD-L1) expression of tumor cells in non-small cell lung cancer (NSCLC) patients by using a radiomics study based on CT images and clinicopathologic features. MATERIALS AND METHODS:A total 390 confirmed NSCLC who performed chest scan i mmunohistochemistry (IHC) examination PD-L1 tumors with clinic data were collected this retrospective study, which divided into two cohorts namely, training (n = 260) validation 130) cohort. Clinicopathologic...
We report a facile synthesis of bifunctional Fe3O4-Ag125I heterodimers for use as dual-modality imaging agents in magnetic resonance (MR) and single-photon emission computed tomography (SPECT). introduced 125I, which is clinically used radioisotope, SPECT reporter, into Fe3O4-Ag heterodimer nanoparticles to provide new type contrast agent MRI imaging.
Because of the blood-brain barrier and high infiltration glioma cells, diagnostic accuracy treatment efficiency gliomas are still facing challenges. There is an urgent need to explore integration therapeutic methods achieve accurate diagnosis, guide surgery, inhibit postoperative recurrence. In this work, we developed a macrophage loaded with photothermal nanoprobe (MFe3O4-Cy5.5), which able cross accumulate into deep multimodal imaging guided surgery purposes. With desirable probing depth...
The long-term effects and outcomes of human mesenchymal stem cell (MSC) therapy in patients with severe coronavirus disease 2019 (COVID-19) remain poorly understood. This study aimed to evaluate the extended safety efficacy MSC treatment COVID-19 who participated our earlier randomized, double-blind, placebo-controlled clinical trial, follow-up conducted over 3 years. One hundred were randomized receive either an infusion (n = 65, 4 × 107 cells/dose, on days 0, 3, 6) or a placebo, both...
Tinnitus persists as a significant public health challenge with elusive neurochemical underpinnings. Emerging evidence implicates dysregulated excitatory-inhibitory neurotransmission in the anterior cingulate cortex (ACC), limbic-auditory hub governing tinnitus salience. This study investigates dynamic ACC changes during progression. Using single-voxel magnetic resonance spectroscopy (MRS), GABA+/creatine (Cr) and Glx (glutamate+glutamine)/Cr ratios were measured of 16 recent-onset (RO; <6...
Cancer imaging and therapy in the second near-infrared (NIR II) window have gained increasing interest owing to high light penetration depth minimal optical scattering NIR II region (1000-1350 nm). Meanwhile, integrating multiple diagnostic therapeutic functions into one simple nanoparticle system is of vital significance for cancer theranostics. Herein, we prepare worm-like platinum (Pt) nanoparticles (Pt nanoworms) a facile way. The Pt nanoworms with surface modification show long blood...
Preoperative assessment of lymphovascular invasion(LVI) rectal cancer has very important clinical significance. However, accurate preoperative imaging evaluation LVI is highly challenging because the resolution MRI still limited. Relatively few studies have focused on prediction with tool radiomics, especially in patients negative statue MRI-based extramural vascular invasion (mrEMVI).The purpose this study was to explore predictive value biparametric radiomics features for mrEMVI.The data...
No previous study investigated the anatomical changes of scalp and hair follicles between tertiary androgenetic alopecia severe areata using high-resolution magnetic resonance imaging (HR-MRI). This aimed to explore value HR-MRI in assessing alopecia.
With the development of nanotechnology, nanocomposites have been used as bimodal contrast agents for magnetic resonance (MR) and computed tomography (CT) imaging. We developed a facile method synthesis iron oxide@bismuth sulfide core-shell nanocomposites. These bifunctional can be made water-soluble via PEG coating present strong MRI/CT enhancement. Evaluation cytotoxicity by MTT assay shows that low cytotoxicity. The results illustrate great potential imaging MR/CT.