The residents' knowledge, attitudes and practices related to ambient air pollution health will help improve the understanding of environmental protection make policies more targeted effective. This study aimed at knowing behaviors towards health.A cross-sectional survey was conducted in Ningbo, China January 2015. Personal information questions pertaining were collected through questionnaire investigations. Descriptive statistics, chi-square tests multiple unconditional logistic regression...

Abstract Background This study aimed to investigate the associations between ultra-processed food (UPF) consumption and risk of cardiovascular disease all-cause mortality in UK Biobank Cohort. Methods observational prospective evaluated 60 298 participants aged 40 years or older. We used NOVA classification system identify categorize UPF. The among UPF consumption, (CVD) incidence were estimated using multivariable Cox proportional hazards models. Dose–response analysis CVD was performed a...

Background Although inflammation has been linked to nonalcoholic fatty liver disease (NAFLD), most studies have focused only on a single indicator, leading inconsistent results. Therefore, large prospective study that includes variety of well-documented and composite indicators is needed. This aimed thoroughly investigate the potential associations between different systemic inflammatory NAFLD in UK Biobank cohort. Methods After excluding ineligible participants, 378,139 individuals were...

Abstract Regulatory T cells (Tregs), a key mediator in regulating anti-tumor immune suppression, tumor escape, metastasis and relapse, are considered an important therapeutic target immunotherapy of human cancers. In the present investigation, elevated CD19 + CD24 CD38 regulatory B (Bregs) were observed PBMCs invasive carcinoma breast (IBCa) patients compared with that fibroadenoma (FIBma) or healthy individuals, positive correlation existed between Bregs CD4 CD25 CD127 − Tregs ( r = 0.316,...

Background Evidence about the association between Bisphenol A (BPA) and risk of recurrent miscarriage (RM) in human being is still limited. Objective We evaluated urinary BPA concentrations with RM being. Methods hospital-based 1:2 matched case-control study on was carried out Suzhou Kunshan Jiangsu Province China August 2008 November 2011. Total 264 eligible urine samples (102 patients 162 controls) were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The Wilcoxon...

To evaluate the burden of air pollution on years life lost (YLL) in addition to mortality, we conducted a time series analysis based data pollution, meteorological conditions and 163,704 non-accidental deaths Ningbo, China, 2009-2013. The mean concentrations particulate matter with aerodynamic diameter <10 μm, <2.5 sulfur dioxide nitrogen were 84.0 μg/m(3), 60.1 25.1 μg/m(3) 41.7 respectively. An increase 10-μg/m(3) was associated 4.27 (95% confidence interval [CI] 1.17-7.38), 2.97 CI...

Large-scale molecular profiling data have offered extraordinary opportunities to improve survival prediction of cancers and other diseases detect disease associated genes. However, there are considerable challenges in analyzing large-scale data.We propose new Bayesian hierarchical Cox proportional hazards models, called the spike-and-slab lasso Cox, for predicting outcomes detecting We also develop an efficient algorithm fit proposed models by incorporating Expectation-Maximization steps...

&lt;b&gt;&lt;i&gt;Background and Objectives:&lt;/i&gt;&lt;/b&gt; Few studies have investigated the bidirectional relationship between disability multimorbidity, which are common conditions among older population. Based on data from China Health Retirement Longitudinal Study (CHARLS) Survey of Health, Ageing in Europe (SHARE), we aimed to investigate multimorbidity. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; The activities daily living (ADLs) instrumental (IADLs) scales were used measure...

Abstract Background Although studies have shown that sleep quality (duration) is associated with health-related of life (HRQoL), most these been small-sized and targeted at young middle-aged adults. In addition, few explored the path mechanism disorders leading to impaired HRQoL. Objectives This study aimed determine association between duration HRQoL among elderly in United Kingdom, assess whether depression mediated association, explore role physical activity (PA) association. Methods Data...

While cognitive impairment after stroke is common, trends before are poorly understood, especially among the Chinese population who have a relatively high burden. We aimed to model trajectories of function and new-onset Chinese.A total 13,311 participants aged ≥ 45 years without history were assessed at baseline between June 2011 March 2012 in least one test 2013 (wave 2) 2018 4). Cognitive was using global cognition score, which included episodic memory, visuospatial abilities, 10-item...

Large-scale "omics" data have been increasingly used as an important resource for prognostic prediction of diseases and detection associated genes. However, there are considerable challenges in analyzing high-dimensional molecular data, including the large number potential predictors, limited samples, small effect each predictor. We propose new Bayesian hierarchical generalized linear models, called spike-and-slab lasso GLMs, genes using large-scale data. The proposed model employs a mixture...

The World Health Organization recently released a novel metric for healthy aging: intrinsic capacity (IC). relationship between IC and the incidence of dementia, its subtypes, is unknown. We aimed to analyze dementia subtypes. Moreover, we tested whether genetic susceptibility could be modified by IC.

Gene-environment (G × E) interactions play a critical role in understanding the etiology of diseases and exploring factors that affect disease prognosis. There are several challenges detecting G E for censored survival outcomes, such as high dimensionality, complexity environmental effects, specificity analysis. The effect heredity, which incorporates dependence main effects analysis, has been widely applied study interaction detection. However, it not yet to Bayesian Cox proportional...

Abstract Growing evidence indicates that nomogram combined with the biomarkers of systemic inflammation response could provide more accurate prediction than conventional staging systems in tumors. This study aimed to establish an effective prognostic for resectable thoracic esophageal squamouscell carcinoma (ESCC) based on clinicopathological parameters and inflammation-based scores. We retrospectively investigated 916 ESCC patients who underwent radical esophagectomy. The predictive...

Abstract Dietary quality is an important factor influencing prediabetes, but few studies have applied the Chinese Diet Balance Index (DBI-16) to evaluate dietary of individuals with prediabetes and explore associations between prediabetes. In our study, lower-bound score, higher-bound score diet distance, were respectively calculated assess based on each food group. Logistic regression was used calculate odds ratio (OR) 95% confidence interval (95%CI) unfavorable leading in every subgroup....

Previous studies have indicated that improvement in sleep duration might correlate with better cognition. We aimed to examine the associations between changes and cognitive function.A change from short (SSD) moderate (MSD) was associated global cognition scores (β=0.54, P <0.01). A SSD long (LSD) (β=-0.94, <0.001) or a LSD (β=-1.38, <0.01) lower For individuals MSD, a≥2 h increase (β=-0.89, decrease (β=-0.70, cognition.For sleepers, correlated there no need reduce duration. Excessive...

Abstract To examine the prospective associations between total cholesterol (TC) variability and cognitive function in a large sample of Chinese participants aged 45 years above. A 6,377 people who participated China Health Retirement Longitudinal Study (CHARLS) were included. TC was defined as intra-individual standard deviation over two blood tests CHARLS 2011 2015 (Wave 1 Wave 3). Cognitive assessed by global cognition score, which included three tests: episodic memory, figure drawing...

Background Few studies have investigated the bidirectional association between depression and multimorbidity from a longitudinal perspective. We aimed to explore relationship in middle-aged elderly Chinese population.Methods Participants aged 45 years older China Health Retirement Longitudinal Study (CHARLS) were included. Depression was measured with 10-item version of Center for Epidemiological Studies Scale (CESD-10). In stage I, we assessed baseline follow-up multimorbidity. II, examined...