A5020114916- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Lymphoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Cancer Treatment and Pharmacology
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Advanced Breast Cancer Therapies
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Renal cell carcinoma treatment
Soochow University
2016-2025
Eye & ENT Hospital of Fudan University
2025
Fudan University
2025
The First People's Hospital of Changzhou
2014-2025
Jilin Province Tumor Hospital
2014-2017
Academy of Medical Sciences
2016
Second Affiliated Hospital of Nanjing Medical University
2016
XinHua Hospital
2016
Academy of Military Medical Sciences
2016
Fudan University Shanghai Cancer Center
2016
Purpose There is currently no standard treatment strategy for patients with advanced metastatic gastric cancer experiencing progression after two or more lines of chemotherapy. We assessed the efficacy and safety apatinib, a novel vascular endothelial growth factor receptor 2 tyrosine kinase inhibitor, in gastroesophageal junction adenocarcinoma whom at least prior chemotherapy had failed. Patients Methods This was randomized, double-blind, placebo-controlled phase III trial. from 32 centers...
Abstract Background It has been well established that circular RNAs (circRNAs) play an important regulatory role during tumor progression. Recent studies have indicated even though circRNAs generally regulate gene expression through miRNA sponges, they may encode small peptides in pathogenesis. However, it remains largely unexplored whether are involved the tumorigenesis of colon cancer (CC). Methods The profiles CC tissues were assessed by circRNA microarray. Quantitative real-time PCR,...
Cancer immunotherapy has shown great promise as a new standard cancer therapeutic modality. However, the response rates are limited for current approach that depends on enhancing spontaneous antitumor immune responses. Therefore, increasing tumor immunogenicity by expressing appropriate cytokines should further improve immunotherapy. IL-33 is member of IL-1 family and released necrotic epithelial cells or activated innate thus considered "danger" signal. The role in promoting type 2...
Apatinib is a tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2(VEGFR-2). This study was conducted to assess the efficacy and safety of apatinib in patients with non-triple-negative metastatic breast cancer who had received prior chemotherapy for their disease. multicenter, open-label, single arm enrolled cancer, pretreated anthracycline, taxanes capecitabine, failed setting at least 1 most 4 regimens one endocrine drug hormone receptor-positive as well...
Abstract Background N‐acetyltransferase 10 ( NAT10 ) is the only enzyme known to mediate N4‐acetylcytidine (ac4C) modification of mRNA and crucial for stability translation efficiency. However, its role in cancer development prognosis has not yet been explored. This study aimed examine possible colon cancer. Methods The expression levels were evaluated by immunohistochemical analyses with a tissue microarray, prognostic value patients was further analyzed. Quantitative real‐time polymerase...
Mesenchymal stem cell (MSC)-based therapy is a promising approach to treat various inflammatory disorders including multiple sclerosis. However, the fate of MSCs in microenvironment largely unknown. Experimental autoimmune encephalomyelitis (EAE) well-studied animal model We demonstrated that autophagy occurred during their application for EAE treatment. Inflammatory cytokines, e.g., interferon gamma and tumor necrosis factor, induced synergistically by inducing expression BECN1/Beclin 1....
Background/Aims: PD-L1 (Programmed cell death 1 ligand 1, PD-L1), an essential immune checkpoint molecule in the tumor microenvironment, is important target for cancer immunotherapy. We have previously reported that its expression human gastric and esophageal tissues significantly associated with progression patients’ postoperative prognoses. Its cells well known to inhibit T cell-mediated anti-tumor response, this mechanism of action has been targeted As now, autonomous effect on not...
Background/Abstract: PD-L1 has been an important target of cancer immunotherapy. We have showed that in human gastric tissues, over-expression was significantly associated with progression and patients' postoperative prognoses. However, as now, how regulates the biological function cells still remains elusive.We constructed stable knockdown expression cell lines by using RNAi method, further investigated changes functions including viability, migration, invasion, cycle, apoptosis,...
Gastric cancer is one of the leading causes cancer-related death due to late diagnosis with high metastatic frequency. In this study, impact tumor secreted exosomes on immune function in environment was investigated using isolated from gastric cell lines MKN-28, MKN-45, and SGC-7901. Results show that derived all these changed gene expression cytokine secretion levels CD8+ T cells. They also block cycle progression, induced apoptosis Image analysis fluorescent labeled three injected...
Tissue-resident CD8+T cells (CD103+CD8+T cells) are the essential effector cell population of anti-tumor immune response in tissue regional immunity. And we have reported that IL-33 can promote proliferation and function tissue-resident CD103+CD8+T cells. As now, immunolocalization prognostic values human hepatocellular carcinoma (HCC) intrahepatic cholangiocarcinoma (ICC) still remain to be illustrated.In our present study, used microarrays HCC ICC, multicolor immunohistochemistry (mIHC),...
Background The goal of this study is to evaluate the effectiveness S-1/Oxaliplatin vs. Doxifluridine/Oxaliplatin regimen and identify miRNAs as potential prognostic biomarkers in gastric cancer patients. expression candidate was quantified from fifty-five late stage FFPE specimens. Experimental Design Gastric patients with KPS>70 were recruited for trial. control group treated 400 mg/twice/day Doxifluridine plus i.v. Oxaliplatin at 130 mg/m2/first day/4 week cycle. testing S-1 40...
Background Combination immunotherapy based on immune checkpoint inhibitors (ICIs) has shown great success in the treatment of many types cancers and become mainstream comprehensive cancers. Ablation combination with achieved tremendous efficacy some preclinical clinical studies. To date, our team proved that ablation ICIs was a promising antitumor therapeutic strategy for liver metastasis colorectal cancer (CRC). Moreover, we found expression T cell immunoglobulin immunoreceptor...
MicroRNAs (miRNAs or miRs) are small, non-coding, single-stranded RNA molecules that regulate gene expression at the post-transcriptional level to repress protein of target genes. Among these, miR-181b has been found be a critical regulatory miRNA linking inflammation and cancer. The functional significance in various tumors translational research suggests it exhibits great potential as predictive prognostic biomarker. Extensive efforts underway identify mRNA targets affected networks, which...
Background/Aims: The status of interferon (IFN) signaling pathway has been shown to be closely associated with the response immune checkpoint blockade therapy against advanced human cancers. IFN-induced protein tetratricopeptide repeats 2 (IFIT2), also known as IFN-stimulated gene 54 (ISG54), is one most highly responsive ISGs, which can inhibit proliferation and migration cancer cells, regulate viral replication, resulting in anti-cancer anti-viral effects. In present study, we aimed...
Desmoid fibromatosis (DF) is a rare low-grade benign myofibroblastic neoplasm that originates from fascia and muscle striae. For giant chest wall DF, surgical resection offer radical form of treatment the causing defects usually need repair reconstruction, which can restore structural integrity rigidity thoracic cage. The past decade witnessed rapid advances in application various prosthetic material surgery. However, three-dimensional (3D)-printed custom-made titanium ribs have never been...
Objective: To investigate the efficacy and feasibility of transoral robotic surgery (TORS) for resection tumors in parapharyngeal spaces. Methods: The clinical data 57 patients who underwent TORS space from September 2018 to February 2024 were retrospectively analyzed. These treated at five medical institutions: First Affiliated Hospital China Medical University, Eye & ENT Fudan Sun Yat-sen Memorial Hospital, Tongji College, Huazhong University Science Technology, Cancer Center. 28 males 29...