A5100735734- Sphingolipid Metabolism and Signaling
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Lipoproteins and Cardiovascular Health
- Phagocytosis and Immune Regulation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peroxisome Proliferator-Activated Receptors
- Blood Coagulation and Thrombosis Mechanisms
- Pancreatitis Pathology and Treatment
- Ferroptosis and cancer prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Clusterin in disease pathology
- Cellular transport and secretion
- Regulation of Appetite and Obesity
- Immunotherapy and Immune Responses
- Drug Transport and Resistance Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Hormonal Regulation and Hypertension
- ATP Synthase and ATPases Research
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Estrogen and related hormone effects
- Cancer Immunotherapy and Biomarkers
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Immune Response and Inflammation
First Affiliated Hospital of Fujian Medical University
2025
Fujian Medical University
2025
Center for Excellence in Brain Science and Intelligence Technology
2025
Chinese Academy of Sciences
2025
University of Chinese Academy of Sciences
2025
Kunming Institute of Zoology
2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2025
Lund University
2013-2024
Zhongda Hospital Southeast University
2024
Baotou Central Hospital
2014-2024
A novel human apolipoprotein designated M (apoM) is described. The unique N-terminal amino acid sequence of apoM was found in an approximately 26-kDa protein present a extract triglyceride-rich lipoproteins (TGRLP). isolated cDNA (734 base pairs) encoded 188-amino residue-long protein, distantly related to the lipocalin family. mRNA detected liver and kidney. Western blotting demonstrated be high density lipoprotein (HDL) lesser extent TGRLP low (LDL). first 20 residues constituted...
Abstract Background Macrophage proinflammatory activation contributes to the pathology of severe acute pancreatitis (SAP) and, simultaneously, macrophage functional changes, and increased pyroptosis/necrosis can further exacerbate cellular immune suppression during process SAP, where cyclic GMP–AMP synthase (cGAS)–stimulator interferon genes (STING) plays an important role. However, function mechanism cGAS–STING in SAP-induced lung injury (LI) remains unknown. Methods Lipopolysaccharide...
Alkaline sphingomyelinase (alk-SMase) hydrolyzes dietary sphingomyelin and generates sphingolipid messengers in the gut. In present study, we purified enzyme, identified a part of amino acid sequence, found cDNA GenBank™ coding for protein. The contains 1841 bp, open reading frame encodes 458 acids. Transient expression linked to Myc tag COS-7 cells increased alk-SMase activity cell extract by 689-fold medium 27-fold. High was also anti-Myc immunoprecipitated proteins cross-reacted with...
Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor (MDSCs) in a tumor microenvironment, contributing to escape from immunological attack. Although dendritic cell-based cancer vaccines initiate antitumor immune responses, tumor-educated (TEDCs) involved tolerance induction have attracted much attention recently. In this study, we investigated effect β-glucan on TEDCs found that treatment could promote maturation migration...
790 Background: Fexagratinib (former AZD4547), a selective and potent oral inhibitor of FGFR1-3, has shown promising efficacy safety in phase I trials among solid tumor pts with FGFR1-3 alterations, including mUC. This study (NCT05086666) aimed to assess Fexa previously treated Chinese mUC FGFR alterations. Methods: Pts harboring FGFR3 alterations (including activating mutations or fusion detected via NGS panel) who failed at least 1 prior therapy were platinum- ineligible, enrolled....
Abstract —The triglyceride (TG) concentration in plasma is an independent risk factor for coronary heart disease. There evidence that TG-rich lipoprotein (TGRLP), ie, chylomicrons (CMs), chylomicron remnants (CMRs), and VLDLs associate with VII prothrombin the association enhances a platelet Xa–mediated activation when CM-prothrombin complex exposed to platelets. In this study, we examined of vitamin K–dependent coagulation factors VII, IX, X, prothrombin, as well anticoagulation protein C...
Apolipoprotein M (apoM) is a 26-kDa protein that mainly associated with high-density lipoprotein (HDL) in human plasma, small proportion present triglyceride-rich lipoproteins (TGRLP) and low-density (LDL). Human apoM gene located p21.31 on chromosome 6 (chromosome 17, mouse). cDNA (734 base pairs) encodes 188-amino acid residue-long protein. It belongs to lipocalin superfamily. tissue expression array study indicates only expressed liver kidney amounts are found fetal kidney. In situ mRNA...
An important issue in quantitative trait loci (QTL) detection is the use of phenotypic measurement as a dependent variable. Daughter yield deviations (DYDs) unit choice are not available for all traits interest. The de‐regressed proofs (DRPFs) estimated breeding values (EBVs) an alternative to using daughter deviations. objective this study was examine possible differences between DYDs and DRPFs within QTL detection. pedigree used part granddaughter design German effort. Consisting marker...
Abstract Objective To determine plasma apolipoprotein M (apoM) levels and other lipid profiles in hepatocellular carcinoma (HCC) patients compared to chronic liver diseases normal subjects. Materials methods 36 HCC, 68 hepatitis, 29 cirrhosis 64 controls were subjected the present study. Serum lipids, lipoproteins, AI (apoAI) apoB determined by conventional methods. Plasma apoM semi-quantitatively both dot-blotting western blotting analysis. Results of triglycerides (TG), HDL-cholesterol,...