A5100419841- Glycosylation and Glycoproteins Research
- Advanced Proteomics Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Renal Diseases and Glomerulopathies
- Metabolomics and Mass Spectrometry Studies
- Monoclonal and Polyclonal Antibodies Research
- Bacteriophages and microbial interactions
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- Tryptophan and brain disorders
- Mass Spectrometry Techniques and Applications
- Galectins and Cancer Biology
- Receptor Mechanisms and Signaling
- Gut microbiota and health
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Sarcoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Genomics and Phylogenetic Studies
- Metabolism and Genetic Disorders
- Liver Disease Diagnosis and Treatment
- Stress Responses and Cortisol
- Osteoarthritis Treatment and Mechanisms
- Histone Deacetylase Inhibitors Research
- Carbohydrate Chemistry and Synthesis
Sichuan University
2015-2025
West China Hospital of Sichuan University
2013-2025
Huazhong University of Science and Technology
2022-2025
Liaoning Provincial People's Hospital
2025
China Medical University
2012-2025
Weifang University
2025
Southwest University of Science and Technology
2025
Hubei University of Medicine
2025
Taihe Hospital
2010-2025
Wuhan Prevention and Treatment Center for Occupational Diseases
2025
Abstract Background This study aimed to evaluate the effectiveness and efficiency of PBL–CBL combined teaching in thyroid surgery make observations from students’ perspectives, based on their satisfaction with learning process. Methods We prospectively enrolled 354 fourth-year students majoring clinical medicine, along 232 residents, September 2014 June 2019. These participants were randomly allocated into either group or traditional lecture-based classroom attend a course about nodules....
Abstract Glycoproteomics is a powerful yet analytically challenging research tool. Software packages aiding the interpretation of complex glycopeptide tandem mass spectra have appeared, but their relative performance remains untested. Conducted through HUPO Human Initiative, this community study, comprising both developers and users glycoproteomics software, evaluates solutions for system-wide analysis. The same spectrometry based datasets from human serum were shared with participants team...
Activation of lymphocytes through their antigen receptors leads to mobilization intracellular Ca2+ ions. This process requires expression SLP adaptors and involves phosphorylation phospholipase C-γ isoforms by the Tec-related protein tyrosine kinase Btk in B cells Itk T cells. The SH2 domain is essential for mutations this lead X-linked agammaglobulinemia immuno deficiency humans. Here we show that, contrast domains from other signaling proteins, exhibit a restricted binding specificity....
The glycoprotein spike (S) on the surface of severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a determinant for viral invasion and host immune response. Herein, we characterized site-specific N-glycosylation S protein at level intact glycopeptides. All 22 potential N-glycosites were identified in S-protein protomer found to be preserved among 753 SARS-CoV-2 genome sequences. glycosites exhibited glycoform heterogeneity as expected human cell-expressed subunit. We masses that...
Major depressive disorder is a devastating mental illness leading to lifetime prevalence of higher than 16% on individuals. The treatment delay and inevitable adverse effects are major limitations current depression interventions. Emerging evidence indicates that curcumin produced significant antidepressant properties in both rodents humans without effects. Therefore, it necessary further clarify the actions underlying mechanism depressed patients. A total 108 male adults aged between 31 59...
Recently, it has been established that the human resident microbiota plays key roles in health maintenance. Therefore, become an emerging prevention and treatment target for metabolic syndrome. The associated with chronic inflammation shown to contribute onset of type 2 diabetes mellitus (T2DM). Moreover, is altered development T2DM its comorbid medical conditions/diseases, including diabetic retinopathy, kidney toxicity, atherosclerosis, hypertension, foot ulcers, cycstic fibrosis...
Angiotensin-converting enzyme 2 (ACE2) is a potent negative regulator capable of restraining overactivation the renin-angiotensin system, which contributes to exuberant inflammation after bacterial infection. However, mechanism through ACE2 modulates this inflammatory response not well understood. Accumulating evidence indicates that infectious insults perturb activity, allowing for uncontrolled inflammation. In current study, we demonstrate pulmonary levels are dynamically varied during...
The hypoglycemic effect of Phellinus linteus polysaccharide extract (PLPE) has been documented in several previous studies, but the functional interactions among PLPE, gut microbiota, and remain unclear. We examined regulatory PLPE on molecular mechanism underlying improvement insulin resistance, using a type 2 diabetic rat model. Here, 24 male Sprague-Dawley rats were randomly divided into four groups that subjected to intervention saline (normal model control group), metformin (120...
Abstract A recent study has discovered that mesenchymal stem cells (MSCs) are recruited into tumors and MSC‐derived exosomes in a novel mechanism of cell‐to‐cell communication human cancers. Here, this study, we explore the impact microRNA‐208a (miR‐208a)‐enriched derived from bone marrow‐derived (BMSCs) on osteosarcoma cells. Human MG‐63 Saos‐2 were exposed to BMSCs‐derived treated with either miR‐208a mimic or inhibitor. The MTT assay, transwell migration soft agar colony formation assay...
Extracellular vesicle (EV)-based therapies have emerged as a promising means in regenerative medicine. However, the conventional EV therapy strategy displays some limitations, such inefficient production and lack of tissue-specific repair effects. Here, it is reported that neonatal-tissue-derived (NEXT) potent for precision tissue repair. In brief, large amounts EVs with higher yield/purity can be readily isolated from desired tissues less time/cost compared to cell-culture-based method....
Abstract To investigate the ability of ratio blood urea nitrogen (BUN) to serum albumin (BAR) in patients with sepsis intensive care units (ICUs) predict prognosis short-and long-term death. Data are from Marketplace for Intensive Care Medical Information IV (MIMIC-IV v2.0) database as defined by SEPSIS-3. The primary outcome was 30-day mortality and secondary 360-day mortality. Kaplan–Meier (KM) survival curves were plotted describe differences BAR different subgroups area under curve (AUC)...
Abstract In situ precise detection of bioactive molecules with high sensitivity and spatiotemporal resolution is essential for studying physiological events disease diagnosis. The utilization versatile fluorescent probes in fluorescence imaging offers a powerful tool vivo biomarkers closely associated pathological conditions. However, the dynamic behavior leading to rapid clearance small molecule from regions interest severely compromises their potential imaging. Notably, self‐immobilizing...
Abstract Oxidative stress plays a crucial role in organ aging and related diseases, yet the endogenous regulators involved remain largely unknown. This work highlights importance of metabolic homeostasis protecting against oxidative large intestine. By developing low-input user-friendly pipeline for simultaneous profiling five distinct cysteine (Cys) states, including free SH, total Cys oxidation (Sto), sulfenic acid (SOH), S -nitrosylation (SNO), -glutathionylation (SSG), we shed light on...
Systemic sclerosis (SSc) is a perplexing autoimmune disorder, characterized by mysterious causes, high mortality rates, and lack of effective treatments. The role abnormal glycosylation in the onset diseases has been recognized for some time. Nonetheless, intricate details intact glycopeptides SSc remain elusive owing to challenges their detection. In this study, we plasma immunoglobulin G (IgG) N-glycopeptides from 30 patients healthy controls (HCs) via our recently developed glycopeptide...
An increasing number of studies show that teachers have one the most stressful occupations. Long-term work stress may lead to burnout, which gravely affects teachers' physical and mental health, lowers quality their work, and, in turn, impairs students' health development imperils sound education. This article analyzes harm done by teacher defines its causes, suggests preventive strategies.