A5101859411- HIV Research and Treatment
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- HIV/AIDS Research and Interventions
- Respiratory Support and Mechanisms
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 detection and testing
- Mesenchymal stem cell research
- T-cell and B-cell Immunology
- Gut microbiota and health
- COVID-19 and healthcare impacts
- Congenital Diaphragmatic Hernia Studies
- Cancer-related molecular mechanisms research
- Mosquito-borne diseases and control
- Geotechnical Engineering and Underground Structures
- Reproductive System and Pregnancy
- Vector-borne infectious diseases
- Extracellular vesicles in disease
- HIV-related health complications and treatments
- Structural Response to Dynamic Loads
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Inflammasome and immune disorders
First Hospital of Jilin University
2025
Jilin University
2025
Guangzhou University
2025
Chinese PLA General Hospital
2020-2024
Beijing University of Chemical Technology
2024
Powerchina Huadong Engineering Corporation (China)
2023-2024
PowerChina (China)
2023-2024
National Clinical Research Center for Digestive Diseases
2020-2023
Southern Medical University
2023
302 Military Hospital of China
2016-2020
In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection, the relationship between severity and host immune response is not fully understood. Here we performed single-cell RNA sequencing in peripheral blood samples of 5 healthy donors 13 patients with COVID-19, including moderate, convalescent cases. Through determining transcriptional profiles cells, coupled assembled T cell receptor B sequences, analyzed functional properties cells. Most...
No effective drug treatments are available for coronavirus disease 2019 (COVID-19). Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage, death, or long-term functional disability in survivors require clinical evaluation. We performed a parallel assigned controlled, non-randomized, phase 1 trial evaluate safety of human umbilical cord-derived mesenchymal stem cells (UC-MSCs) infusions treatment patients with moderate and severe...
Treatment of severe Coronavirus Disease 2019 (COVID-19) is challenging. We performed a phase 2 trial to assess the efficacy and safety human umbilical cord-mesenchymal stem cells (UC-MSCs) treat COVID-19 patients with lung damage, based on our 1 data. In this randomized, double-blind, placebo-controlled trial, we recruited 101 damage. They were randomly assigned at 2:1 ratio receive either UC-MSCs (4 × 10
Chronic HIV-1 infection is generally characterized by progressive CD4+ T cell depletion due to direct and bystander death that closely associated with persistent replication an inflammatory environment in vivo. The mechanisms underlying the loss of cells patients chronic are incompletely understood. In this study, we simultaneously monitored caspase-1 caspase-3 activation circulating cells, which revealed pyroptotic apoptotic distinct populations different phenotypic characteristics. Levels...
The long-term consequences of human umbilical cord-derived mesenchymal stem cell (UC-MSC) treatment for COVID-19 patients are yet to be reported. This study assessed the 1-year outcomes in with severe COVID-19, who were recruited our previous UC-MSC clinical trial.In this prospective, longitudinal, cohort study, 100 enrolled phase 2 trial prospectively followed up at 3-month intervals 1 year evaluate safety and effectiveness treatment. primary endpoint was an altered proportion whole-lung...
A novel coronavirus (SARS-CoV-2) was recently identified in patients with acute respiratory disease and spread quickly worldwide. specific rapid diagnostic method is important for early identification. The reverse-transcription recombinase-aided amplification (RT-RAA) assay a detection several pathogens. Assays were performed within 5–15 min as one-step single tube reaction at 39 °C. In this study, we established two RT-RAA assays the S orf1ab gene of SARS-CoV-2 using clinical specimens...
Using normalization of CD4 counts as the main evaluation parameter complete immune restoration for HIV-1 patients under antiretroviral therapy (ART) might be not enough. A comprehensive system more accurately reflecting are urgently needed. Totally, 91,805 from 17 tertiary hospitals in China during 2005–2018 were included this study. Immune and mortality assessed. Patients initiated ART with baseline <50, 50–199, 200–349, 350–499, ≥500 cells/μL, results showed an increase median to 445...
B cell follicles are immune-privileged sites where intensive HIV-1 replication and latency occur, preventing a permanent cure. Recent study showed that CXCR5+ NK cells in can inhibit SIV African green monkeys, but this has not been reported infected patients.Lymphocytes tissue sections of lymph node were collected from 11 positive antiretroviral therapy (ART)-naive 19 negative donors. We performed immunofluorescence RNA-scope to detect the location its relationship with RNA, flow cytometry...
Abstract Background Human babesiosis is a worldwide disease caused by intraerythrocytic protozoa of the genus Babesia . It transmitted bites from ixodid ticks, and mechanically blood transfusion. primarily treated with quinine and/or atovaquone, which are not readily available in China. In this study, we developed novel treatment regimen involving doxycycline monotherapy patient severe venatorum infection as an alternative therapeutic medication. The aim our study to provide guidance for...
This study aimed to analyze the clinical characteristics and potential predictors of disease severity in patients with coronavirus 2019 (COVID-19). We retrospectively analyzed data from 64 (37 male 27 female) COVID-19. Their mean age was 47.8 years; 43 (67.2%) cases were non-severe, 21 (32.8%) severe, 2 (3.1%) died. Age serum ferritin levels significantly associated COVID-19 severity. There no significant differences duration severe illness or number days on high-level respiratory support...
Hypervirulent Klebsiella pneumoniae (hvKp) is a major human pathogen associated with liver abscess, pneumonia, meningitis, and endophthalmitis. It challenging to differentiate hvKp from classical (cKp) using conventional methods, necessitating the development of rapid, sensitive, convenient assay for detection. In this study, we constructed recombinase-aided amplification (RAA) method targeting genes peg344 rmpA, also analyzed pathogenic characteristics hvKp. We optimized reaction...
Increased mortality and morbidity occur among human immunodeficiency virus (HIV)-infected patients in whom CD4+ T-cell counts do not increase despite viral suppression with antiretroviral therapy (ART). Here we identified an underlying mechanism. Significantly elevated plasma levels of anti-CD4 immunoglobulin G (IgG) were found HIV-positive immunologic nonresponders (ie, individuals ≤350 cells/μL), compared responders ≥500 cells/μL) healthy controls. Higher level IgG correlated blunted...
Blood microbiome is important to investigate microbial-host interactions and the effects on systemic immune perturbations. However, this effort has met with major challenges due low microbial biomass background artifacts. In current study, 16S DNA sequencing was applied analyze plasma microbiome. We have developed a quality-filtering strategy evaluate exclude levels of sequences, potential contaminations, artifacts from analyses. Furthermore, we our technique in three cohorts, including...
While Klebsiella pneumoniae is a common cause of nosocomial and community-acquired infections, including pneumonia pyogenic liver abscess, little known about the population structure this bacterium. In study, we investigated prevalence molecular characteristics K. isolates from carriers, abscess patients, genomic phenotypic assays were used to determine differences among isolates. A total 232 subtyped into 74 sequence types (STs). The different sources had their own STs, predominant subtypes...
Recurrent opportunistic infections (OIs) in patients with severely immunosuppressed AIDS remain an unresolved medical challenge despite advancements antiretroviral therapy (ART). To address this gap, we developed HLA-mismatched allogeneic adoptive immune (AAIT) specifically targeting patient population. The safety and efficacy of novel therapeutic approach were preliminarily confirmed our phase 1 trial. Subsequently, a multicenter, open-label, controlled, 2a trial was conducted to evaluate...
Alzheimer's disease is the predominant form of dementia, and disulfidptosis latest reported mode cell death that impacts various processes. This study used bioinformatics to analyze genes associated with in comprehensively. Based on public datasets, differentially expressed were identified, immune infiltration was investigated through correlation analysis. Subsequently, hub determined by a randomforest model. A prediction model constructed using logistic regression. In addition, drug-target...
Human adenovirus type 55 (HAdV-55) is considered a highly virulent pathogen causing severe and even deadly pneumonia in immunocompetent people. The mechanisms of HAdV-55-induced initiation progression remain ambiguous. In the current study, we endeavored to identify novel immune response genes which are substantially involved pathogenesis inflammation HAdV-55-infected patients. patients with upper respiratory tract symptoms (minor patients) (severe were enrolled. Through transcriptome...