A5009305686- HIV Research and Treatment
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- HIV/AIDS Research and Interventions
- Influenza Virus Research Studies
- Asthma and respiratory diseases
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Dermatology and Skin Diseases
- Neonatal Respiratory Health Research
- Mobile Health and mHealth Applications
- Chronic Lymphocytic Leukemia Research
- Immunotherapy and Immune Responses
- Allergic Rhinitis and Sensitization
- Polyomavirus and related diseases
- Lymphoma Diagnosis and Treatment
- Focus Groups and Qualitative Methods
- Multiple Myeloma Research and Treatments
- Platelet Disorders and Treatments
- Immunodeficiency and Autoimmune Disorders
- Glycogen Storage Diseases and Myoclonus
- Frailty in Older Adults
- Acute Myeloid Leukemia Research
- HIV-related health complications and treatments
- Toxin Mechanisms and Immunotoxins
University of Alabama at Birmingham
2025
Medical University of South Carolina
2015-2023
Ralph H. Johnson VA Medical Center
2023
Cincinnati Children's Hospital Medical Center
2022
Canadian Blood Services
2004-2021
University of South Carolina
2016
University at Buffalo, State University of New York
2006
Abstract Multiple genetic loci contribute to the development of systemic lupus erythematosus (SLE). In murine models for SLE, various genes on chromosome four have been implicated. IL-14 is a cytokine originally identified as B cell growth factor. The il14 gene located 4. IL-14α encoded by plus strand using exons 3–10. expression increased in (NZB × NZW)F1 mice. this study, we produced IL-14α-transgenic mice study role autoimmunity. At age 3–9 mo, demonstrate numbers B1 cells peritoneum,...
The role of natural killer (NK) cell function in HIV disease especially the setting long-term antiretroviral therapy (ART) and viral suppression is not fully understood. In current study, we have investigated NK activation healthy controls aviremic ART-treated HIV+ subjects with different degrees immune restoration. We performed a cross sectional study 12 24 HIV-infected including 13 CD4+ T cells above 500 cells/μL defined as "immunologic responders" 11 below 350 non-responders". analyzed...
808 Background: Older adults with gastrointestinal (GI) cancers face a higher risk of treatment toxicities and adverse survival outcomes. However, the variability in these outcomes remains poorly understood. Age-related changes, including progressive loss skeletal muscle gain adipose tissue, contribute to this heterogeneity. Recent studies highlight an association between gauge (SMG) overall (OS) older cancer patients, but its relevance among those GI is unclear. Methods: We included aged ≥...
<h3>Importance</h3> Stiff person syndrome (SPS) is a rare neurological disease causing significant functional disability for patients and presenting therapeutic challenge clinicians. Autologous hematopoietic stem cell transplantation (auto-HSCT) has been used successfully to remit autoimmune-mediated diseases. We report 2 cases of severe SPS treated with auto-HSCT, novel therapy this disease. <h3>Observations</h3> Two anti–glutamic acid decarboxylase antibody–positive had an autologous graft...
Increased autoreactive antibodies have been reported in HIV disease; however, the mechanism accounting for autoantibody induction remains unknown. Herein, we show that seasonal influenza vaccination induces production (e.g., IgG anti-nuclear antibody (ANA) and anti-double-stranded DNA (anti-dsDNA)) some viral-suppressed antiretroviral therapy (ART)-treated HIV+ subjects, but not healthy controls. These autoantibodies were derived from antigen-specific B cells activated "bystander" analyzed...
Increased mortality and morbidity occur among human immunodeficiency virus (HIV)-infected patients in whom CD4+ T-cell counts do not increase despite viral suppression with antiretroviral therapy (ART). Here we identified an underlying mechanism. Significantly elevated plasma levels of anti-CD4 immunoglobulin G (IgG) were found HIV-positive immunologic nonresponders (ie, individuals ≤350 cells/μL), compared responders ≥500 cells/μL) healthy controls. Higher level IgG correlated blunted...
Microbial signals have been linked to autoantibody induction. Recently, we found that purified anti-CD4 autoantibodies from the plasma of chronic HIV-1-infected patients under viral-suppressed antiretroviral therapy (ART) play a pathologic role in poor CD4+ T cell recovery. The purpose study was investigate association systemic microbiome and production HIV. Plasma 12 healthy controls 22 HIV-infected subjects ART were analyzed by MiSeq sequencing. level microbial translocation (LPS, total...
Background: The role and mechanism of drug use or abuse in Antiretroviral Therapy (ART)-treated HIV disease are not completely known. Methods: To investigate the impact on pathogenesis without confounding by replication ART adherence, we first analyzed data from our clinical database 103 HIV+ subjects with viral-suppressed treatment a multiple regression test. Results: We found that users had lower CD4+ T cell counts but higher CD8+ compared to non-drug users, both nadir was independently...
The most commonly used stem cell source for both autologous and allogeneic transplantation is mobilized peripheral blood hematopoietic progenitor cells collected by apheresis. In the 1990s, an Italian group correlation between preapheresis CD34+ count final number of to devise a formula "target value-tailored" (TVT) Using local patient data, Canadian Blood Services Stem Cell Laboratory created similar model determine volume process during apheresis collection. objectives this study were...
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) refractory to conventional therapy can lead marked disability and represents a therapeutic challenge.To report five cases of treatment-refractory disabling CIDP treated with autologous hematopoietic stem cell transplantation (AHSCT).This was retrospective cohort study from tertiary care referral center for both neuromuscular disease AHSCT. Patients AHSCT between 2008 2020 were included. All patients had major persistent...
Abstract Although effective antiretroviral therapy (ART) suppresses HIV viral replication, prevents AIDS-related complications, and prolongs life, a proportion of patients fails to restore the patients’ CD4+ T cell number level healthy individuals. Increased mortality morbidity have been observed in these patients. In current study, we investigated role auto-IgGs apoptosis recovery cross-sectional study. All HIV+ subjects were on viral-suppressive ART treatment with different degree...
Background. Primary sclerosing cholangitis (PSC) is an indication for liver transplantation, but recurrence after transplantation associated with poor outcomes often requiring repeat transplantation. We investigated whether autologous hematopoietic stem cell (aHSCT) could be used to stop progression of recurrent PSC and promote operational tolerance. Methods. Twelve patients were fully evaluated 5 selected aHSCT. Autologous cells collected, purified by CD34 immunomagnetic selection,...
Potential mechanisms of poor CD4+ T cell reconstitution after viral suppression with antiretroviral therapy (ART) in HIV disease have been extensively investigated. We recently discovered that anti-CD4 autoantibody plays a role impaired recovery from ART HIV-infected individuals suppression, which accounts for mechanism specific depletion. However, the pathologic production treated remains unknown. Here we report seasonal influenza vaccination induced IgG autoantibodies, predominant IgG3...
Patient-provider communication is critical for engaging and retaining people living with HIV in care, especially among medically case-managed patients need of service coordination adherence support. Expanding patient-provider channels to include mobile health modalities, such as text messaging video calling, has the potential facilitate ultimately improve clinical outcomes. However, implementation these modalities settings not been well characterized.The purpose this study understand patient...