A5054281421- Salivary Gland Disorders and Functions
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Blood Coagulation and Thrombosis Mechanisms
- Mast cells and histamine
- Protease and Inhibitor Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Blood properties and coagulation
- Urticaria and Related Conditions
- Hemoglobinopathies and Related Disorders
- Neonatal Respiratory Health Research
- Salivary Gland Tumors Diagnosis and Treatment
- Effects of Radiation Exposure
- Erythrocyte Function and Pathophysiology
- Immunodeficiency and Autoimmune Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Ocular Surface and Contact Lens
- Lymphoma Diagnosis and Treatment
- Diabetes and associated disorders
- Cytokine Signaling Pathways and Interactions
- Chronic Lymphocytic Leukemia Research
- Growth Hormone and Insulin-like Growth Factors
- Inflammatory mediators and NSAID effects
- Blood groups and transfusion
University at Buffalo, State University of New York
2016-2025
University of Florida
2022
Sisters of Charity Hospital
1990-2016
Buffalo General Medical Center
1969-2015
Buffalo State University
2006-2015
Kaleida Health
2000-2013
State University of New York
1969-2012
Williams (United States)
2012
ENT and Allergy
2010
Women & Children's Hospital of Buffalo
1963-2007
Objectives Open-labelled clinical trials suggested that low-dose IL-2 might be effective in treatment of systemic lupus erythematosus (SLE). A double-blind and placebo-controlled trial is required to formally evaluate the safety efficacy therapy. Methods randomised, was designed treat 60 patients with active SLE. These received either (n=30) or placebo standard for 12 weeks, were followed up additional weeks. at a dose 1 million IU administered subcutaneously every other day 2 weeks by...
Primary Sjögren syndrome (pSS) is a systemic autoimmune disease associated with dysregulated immune cells, no efficient therapy. There need to study potential therapeutic approaches.To investigate the efficacy, safety, and response of low-dose interleukin 2 (LD-IL-2) in treatment pSS.A double-blind, placebo-controlled randomized clinical trial was conducted 2-group superiority design from June 2015 August 2017. Sixty patients, aged 18 70 years, were recruited Peking University People's...
Namalva, a human B cell lymphoma line, produced factor with molecular weight of approximately 60,000 which enhanced the proliferation normal activated lymphocytes. The also certain lines. It can be distinguished physiologically and biochemically from other lymphokines known to enhance proliferation, namely, interleukin (IL) 1, IL 2, interferon. production growth by tumor lines may contribute their ability grow autonomously reflect an important component neoplastic potential cell. tumors...
Whole-body irradiation of mice with 300 or 400 R causes a precipitous fall in thymus weight, followed by an increase the mitotic index and almost complete restoration mass. This phase is secondary weight gradual recovery. can be prevented intravenous injection bone marrow shielding hind limbs during irradiation. The hypothesis proposed that depends on migration cells from to for maintenance its cell population. Bone chromosome markers injected intravenously into normal lightly irradiated...
Abstract The autoimmune exocrinopathy, Sjögren’s syndrome (SS), is associated with secretory defects in patients, including individuals mild lymphocytic infiltration and minimal glandular damage. mechanism(s) underlying the dysfunction not known. We have used minor salivary gland biopsies from SS patients healthy to assess acinar cell function morphologically intact areas. report that agonist-regulated intracellular Ca 2+ release, critically required for entry fluid secretion, defective...
Abstract Multiple genetic loci contribute to the development of systemic lupus erythematosus (SLE). In murine models for SLE, various genes on chromosome four have been implicated. IL-14 is a cytokine originally identified as B cell growth factor. The il14 gene located 4. IL-14α encoded by plus strand using exons 3–10. expression increased in (NZB × NZW)F1 mice. this study, we produced IL-14α-transgenic mice study role autoimmunity. At age 3–9 mo, demonstrate numbers B1 cells peritoneum,...
High molecular weight B cell growth factor (HMW-BCGF) produced by a T line was purified to homogeneity and demonstrated bind specifically activated human cells. A monoclonal antibody HMW-BCGF developed that (a) inhibited the activity of in enhancing proliferation, (b) bound Western blots, (c) absorbed from culture supernatants, (d) an internally labeled protein T-ALL supernatant which comigrates with on sodium dodecyl sulfate-polyacrylamide gels. This should help cloning gene for further...
In the serum of normal prematures and premature infants with respiratory distress syndrome, plasminogen was absent. mature newborns levels were low, as compared to adults. euglobulin fraction plasma, level highest in newborns, lower healthy prematures, lowest syndrome. Antiplasmin exceptionally high about a fourth or without Plasminogen activator activity found more often blood syndrome than infants. This may be due liberation tissue activators consequence hypoxia. Because absence substrate...
Sjogren's syndrome (SS) is a chronic autoimmune disease mainly affecting salivary and lacrimal glands. Current diagnostic criteria for SS utilize anti-Ro anti-La as serological markers. Animal models have identified novel autoantibodies, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) parotid secretory (PSP). These antibodies are seen in the animals at an earlier stage of than anti-La. The current studies were designed to evaluate these autoantibodies sera...
While viruses have long been shown to capitalize on their limited genomic size by utilizing both strands of DNA or complementary DNA/RNA intermediates code for viral proteins, it has assumed that human retroviruses all major proteins translated only from the plus sense strand RNA, despite requirement a dsDNA proviral intermediate. Several studies, however, suggested presence antisense transcription HIV-1 and HTLV-1. More recently an transcript responsible HTLV-1 bZIP factor (HBZ) protein...
The etiology of salivary gland injury in primary Sjögren's disease is not well understood. We have previously described a mouse model disease, IL-14α transgenic (IL14αTG) mice, which reproduces many the features human disease. now demonstrate critical role for lymphotoxin α (LTA) pathogenesis IL14αTG mice. mice express LTA mRNA their glands and spleen produce soluble protein secretions. When were crossed with LTA(-/-) IL14αTG.LTA(-/-) retained normal secretions did develop either lymphocytic...
Objectives The objective of this paper is to investigate conventional and nonconventional brain magnetic resonance imaging (MRI) findings in systemic lupus erythematosus (SLE) patients with diffuse neuropsychiatric involvement (dNPSLE) compared healthy controls (HCs). Methods Twenty-six (26) SLE one or more NP syndromes related the central nervous system (CNS) 36 age- sex-matched HCs were scanned on a 3T MRI using multimodal approach. Univariate multivariate analyses used determine...