A5100770868- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- Advanced Battery Technologies Research
- Advancements in Battery Materials
- Reproductive tract infections research
- Bacteriophages and microbial interactions
- Syphilis Diagnosis and Treatment
- HIV, TB, and STIs Epidemiology
- Immune Cell Function and Interaction
- Environmental Sustainability in Business
- Advanced battery technologies research
- Poxvirus research and outbreaks
- Energy, Environment, Economic Growth
- Adolescent Sexual and Reproductive Health
- Corporate Social Responsibility Reporting
- Alcohol Consumption and Health Effects
- Sensory Analysis and Statistical Methods
- Antioxidant Activity and Oxidative Stress
- Cytomegalovirus and herpesvirus research
- Sex work and related issues
- Immunodeficiency and Autoimmune Disorders
- Vibrio bacteria research studies
- Evolution and Genetic Dynamics
Zhejiang Center for Disease Control and Prevention
2015-2025
Central South University
2024-2025
Shanghai Changzheng Hospital
2024
Experimental Center of Forestry in North China
2024
University of Hong Kong
2022-2023
South China University of Technology
2022
The Graduate Center, CUNY
2022
City University of New York
2022
Lanzhou University
2022
Medical University of South Carolina
2018
In China, human immunodeficiency virus (HIV) poses a significant challenge to older heterosexual adults. This study explored the transmission dynamics of HIV infection among adults in northern Zhejiang Province, China using phylogenetic analysis and networks. pol sequences without any antiretroviral therapy were obtained from newly diagnosed HIV-positive patients Huzhou between 2017 2022. Pairwise genetic distances calculated Trace based on Tamura-Nei 93 method. The network was constructed...
Aims. To examine the nature of relationships between responses to alcohol advertisements and drinking behaviour related problems. role positive negative beliefs about as intervening variables . Design. Survey utilizing a CATI (computer‐assisted telephone interviewing) system, involving interviews with 1012 randomly selected respondents Setting. Respondents were from throughout New Zealand Participants. Eighteen twenty‐nine‐year‐old Zealanders Measurements. Response specific was measured by...
ATMP inhibits the homogeneous catalytic oxidation of Co ions by chelation coordination, preventing decomposition electrolyte. Meanwhile, it can form a stable CEI film at interface, slowing down side reactions.
ABSTRACT Vibrio cholerae is a natural inhabitant of the aquatic environment. However, its toxigenic strains can cause potentially life-threatening diarrhea. A quadruplex real-time PCR assay targeting four genes, cholera toxin gene ( ctxA ), hemolysin hlyA O1-specific rfb , and O139-specific was developed for detection differentiation O1, O139, non-O1, non-O139 prediction their potential. The specificity 100% when tested against 70 V. 31 non- organisms. analytical sensitivity O1 O139 2 CFU...
Abstract As the most dominant HIV-1 strain in China, CRF01_AE needs to have its evolutionary and demographic history documented. In this study, we provide phylogenetic analysis of all pol sequences identified mainland China. were collected from Los Alamos HIV Sequence Database local Chinese provincial centers disease control prevention. Phylogenetic trees constructed identify major epidemic clusters. Bayesian coalescent-based method was used reconstruct time scale history. There 2965 24...
This study aimed to establish a collaborative approach quantify local HIV transmission, which is an issue of great concern public health.We linked HIV-1 pol gene sequences demographic information and epidemiological investigations in Hangzhou (a central city East China). We estimated acquisition rates from collaboration molecular network analysis (with distance-based approach) investigations.Among 1064 newly diagnosed patients with HIV, 857 were acquired subsequently analyzed. Multiple...
In this study, we conducted a detailed molecular epidemiological analysis of HIV-1 epidemic strains in various sexual risk behaviour groups developed area eastern China based on phylogenetic inference, transmission networks, and Bayesian analyses. A total 1083 pol sequences (91.23%, 1083/1187) from newly diagnosed HIV-1-positive patients 2017 to 2020 were successfully obtained involved thirteen subtypes, which the major subtypes CRF07_BC (36.10%, 391/1083) CRF01_AE (34.63%, 375/1083). 485...
In recent years, the population of men who have sex with (MSM) constitute a major group for HIV transmission in China. A total 340 newly reported HIV-infected MSM were recruited proportionally from ten prefectures across Zhejiang province between January and December 2013. Partial pol gene was amplified sequenced. Phylogenetic relationship, network genotypic drug resistance analyses performed on 311 sequences. HIV-1 subtypes including CRF01_AE (55.9%), CRF07_BC (37.6%), subtype B (1.9%),...
Background The assessment of adherence to antiretroviral therapy (ART) is important in order predict treatment outcomes. Lamivudine (3TC) one the most widely used NRTIs China, but its concentrations hair and association with virologic failure drug resistance have not been studied. Methods We conducted a cross-sectional survey investigate 3TC as predictor among HIV patients receiving free ART. also compared capacity self-reported predicting responses. Hair were detected through LC-MS/MS...
The number and proportion of HIV/AIDS patients among older people are continuously rapidly increasing in China. We conducted a detailed molecular epidemiological analysis HIV-1 epidemic strains developed city eastern China found that elderly play crucial role the transmission subtypes high pretreatment drug resistance (PDR). A total 1048 samples were obtained from 1129 (92.8%) newly confirmed HIV-1-positive treatment-naive between 2019 2023. 1316 bp target fragment pol gene was amplified by...
Since China has a unique system of delivering HIV care that includes all patients' records. The factors related to CD4+ T-cell recovery and viral suppression in patients who have low T cell counts at the initiation HAART are understudied despite subsequent virological (viral load < 50 copies/mL) is unknown.The authors conducted retrospective cohort study using data from national treatment sub-database Zhejiang province identify records HIV+ patients. Patient were included if they ≥ 16 years...
HIV transmitted drug resistance (TDR) can compromise antiretroviral therapy (ART) in resource-limited countries like China where ART has been scaled up and thus leads to an important public health concern. The aim of the study was elucidate HIV-1 genetic characteristics TDR Hangzhou, China. Two-hundred eleven ART-naive, newly diagnosed individuals were enrolled during January August 2013. Specimens classified as recent or chronic infections using BED capture enzyme immunoassay (BED-CEIA)....
Despite the implementation of health education and free condom distribution for decades, HIV/AIDS epidemic among older adults in China shows no sign declining. This study aims to identify HIV transmission patterns pathways a rural county area provide insight developing effective prevention strategies adults. Epidemiological field surveys combined with phylogenetic analysis were used potential linkage one rapidly increasing A total 160 HIV-positive individuals their sexual partners diagnosed...
HIV drug resistance compromises the ability of anti-retroviral therapy (ART) to suppress viral replication, resulting in treatment failure. This study investigates prevalence pre-treatment (PDR) newly diagnosed individuals a prosperous city (Wenzhou) Southeastern China. A cross-sectional investigation was carried out among 473 ART-naive HIV-1-infected between January and December 2022. The protease–reverse transcriptase (PR-RT) region integrase (IN) HIV-1 were amplified by two separately...
On January 25, 2017, a physician from ZC Hospital in Hangzhou, China, reported to the Zhejiang Provincial Center for Disease Control and Prevention that potential HIV outbreak might have occurred during lymphocyte immunotherapy (LIT) performed at hospital on December 30, 2016. We immediately began investigating identified index case-patient as an LIT patient's husband who donated lymphocytes his wife's later screened HIV-reactive. Subsequent contamination by technician resulted exposure of...
The current prevalence of Herpes simplex virus type 2 (HSV-2) infection is notably high, with individuals afflicted by HSV-2 facing recurrent outbreaks, challenges in achieving remission, and an elevated risk HIV infection. This study aims to investigate the relationship between alcohol consumption
Previous studies have shown that the increased coverage of antiretroviral therapy (ART) could reduce community viral load (CVL) and occurrence new HIV infections. However, impact on reduction transmission among men who sex with (MSM) is much less certain. The frequency infections in MSM been rapidly increasing recent years Hangzhou, China. "Treatment as Prevention" strategy was implemented at a population-level for HIV-infected from January 2014 to June 2016 Hangzhou; it aimed increase ART...
To investigate the HIV-1 molecular epidemiology among young people (18 to 25 years old) in Hangzhou. Plasma samples from 262 newly diagnosed HIV-1-infected patients were collected between 2009 and 2013 Hangzhou of Zhejiang province. nucleotide sequences pol gene regions amplified using a nested polymerase chain reaction method sequenced. Phylogenetic recombination analyses used determine genotypes. Based on all generated, subtype/circulating recombinant forms (CRFs) distribution was as...
Abstract Although effective antiretroviral therapy (ART) suppresses HIV viral replication, prevents AIDS-related complications, and prolongs life, a proportion of patients fails to restore the patients’ CD4+ T cell number level healthy individuals. Increased mortality morbidity have been observed in these patients. In current study, we investigated role auto-IgGs apoptosis recovery cross-sectional study. All HIV+ subjects were on viral-suppressive ART treatment with different degree...
Recently, a great deal of literature has discussed the effects carbon emissions trading scheme (CETS) and factors that affect corporate environmental information disclosure (CEID) level. However, no researchers have studied how CETS affects CEID Based on difference-in-difference-in-differences model, we discover can improve The findings are robust persistent even after testing for time lags leads effects, changing measure dependent variable, enterprise relocation, adjusting fixed effect...
Orf is caused by the orf virus (ORFV) and a non-systemic, widespread disease afflicting sheep, goats, wild ruminants, humans. Recent outbreaks in sheep goats Jilin other northern Chinese provinces raise concerns about control China. Thirty-five hybridoma clones were constructed from splenocytes of BALB/c mice immunized with natural protein. These hybridomas used to produce antibodies targeting ORFV proteins. Immunological characterization these monoclonal (MAb) showed that 5F2D8 line...
The purpose of this study was to research the molecular transmission and genetic evolutionary characteristics among CRF07_BC-infected patients in a developed area Eastern China.Plasma samples from newly diagnosed HIV-1-positive 2015-2018 basic demographic epidemiological information were obtained. Pol sequences selected for phylogenetic, network, Bayesian analyses.Pol successfully obtained 258 CRF07_BC. Phylogenetic analysis revealed 2 distinct lineages: lineage 1 (66.3%, 171/258), primarily...