A5047517727- Viral Infections and Immunology Research
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Viral gastroenteritis research and epidemiology
- HIV/AIDS drug development and treatment
- RNA and protein synthesis mechanisms
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- Intracerebral and Subarachnoid Hemorrhage Research
- Bacteriophages and microbial interactions
- Whipple's Disease and Interleukins
- Animal Virus Infections Studies
- Bioinformatics and Genomic Networks
- Barrier Structure and Function Studies
- Adolescent Sexual and Reproductive Health
- Neurosurgical Procedures and Complications
- Intracranial Aneurysms: Treatment and Complications
- Pneumocystis jirovecii pneumonia detection and treatment
- Plant Virus Research Studies
- Plant and Fungal Interactions Research
- Environmental Impact and Sustainability
- Fiscal Policy and Economic Growth
- Evolution and Genetic Dynamics
- CAR-T cell therapy research
- HIV, Drug Use, Sexual Risk
Zhengzhou University
2024
Sir Run Run Shaw Hospital
2022-2024
Zhejiang University
2022-2024
National Institute for Viral Disease Control and Prevention
2021-2023
Liaoning University
2023
Abstract Introduction The COVID-19 epidemic control and prevention strategies affected people’s sexual activities behaviors. Little was known about long-term effects of on behaviors among men who have sex with (MSM). This study aimed to examine changes in risky MSM before after the local epidemic. Methods An online survey conducted nationwide from June 1 10, 2022. aged 16 years above, residing China were recruited through convenience sampling. A generalized estimating equation model modified...
Echovirus 30 (E30) infection causes a wide spectrum of diseases with mild symptoms, such as hand, foot, and mouth disease (HFMD), acute flaccid paralysis, aseptic meningitis other diseases, especially one the most common pathogens causing outbreaks. We established novel mouse model E30 by inoculating neonatal mice clinical isolates observed pathological changes induced E30.
Nineteen CVA9 isolates were obtained between 2010 and 2019 from six provinces of mainland China, using the HFMD surveillance network established in China. Nucleotide sequencing revealed that full-length VP1 19 was 906 bases encoding 302 amino acids. The combination thresholds phylogenetic tree nucleotide divergence different genotypes within same serotype led to a value 15–25%, enabled worldwide be categorized into ten genotypes: A–J. showed prototype strain included genotype A, B, C, D, E,...
Chronic subdural hematoma (CSDH) is a prevalent form of intracranial haemorrhage encountered in neurosurgical practice, and its incidence has notably risen recent years. Currently, there lack studies that have comprehensively classified the cells present hematomas removed during surgery, their correlation with CSDH recurrence remains elusive. This study aims to analyse subcellular populations occupancy levels within peripheral blood. analyses blood postoperatively by single-cell sequencing...
Abstract Using a comprehensive molecular epidemiological approach, we characterized the transmission dynamics of HIV‐1 among MSM population in Tianjin, China. Our findings revealed that 38.56% (386/1001) individuals clustered across 109 clusters (TCs), with aged 50 and below being group most commonly transmitting HIV‐1. Among identified TCs, CRF01_AE predominated, followed by CRF07_BC. Notably, CRF07_BC demonstrated higher propensity for forming large compared to CRF01_AE. Birth‐death...
A comprehensive analysis of nationwide survival trends for people living with human immunodeficiency virus/acquired syndrome (HIV/AIDS, PLWHA) from the initial reported case to present has not been conducted. This study evaluated outcomes PLWHA in China 1985 2022.
China implemented the globally synchronized switch from trivalent oral poliovirus vaccine (tOPV) to bivalent OPV (bOPV) on May 1, 2016. During April 2018 2019, first outbreak caused by type 2 circulating vaccine-derived (cVDPV2) after occurred in Xinjiang and Sichuan, China. Methods. We performed sequence analysis of VP1 whole genome determine genomic characteristics cVDPVs, carried out coverage surveys assess risk viral propagation. Surveillance for environment acute flaccid paralysis was...
In 2013, a case of immunodeficiency vaccine-derived poliovirus (iVDPV) was identified in Jiangxi Province, China. this study, we purified 14 type 3 original viral isolates from and characterized the molecular evolution these iVDPVs for 298 days. Genetic variants were found most isolates, with complex genetic evolutionary relationships among variants. A phylogenetic tree constructed based on P1 region showed that classified into lineage B. The dominant B represents major trend virus...
The diversity in currently documented viruses and their morphological characteristics indicates the need for understanding evolutionary of viruses. Notably, further studies are needed to obtain a comprehensive landscape virome, virome host species Yunnan province, China. We implemented metagenomic next-generation sequencing strategy investigate viral diversity, which involved 465 specimens collected from bats, pangolins, monkeys, other species. diverse RNA were analyzed, especially focusing...
Abstract Intracranial aneurysm (IA) is a common cerebrovascular disease. Immune system disorders and endothelial dysfunction are essential mechanisms of its pathogenesis. This study aims to explore the therapeutic effect mechanism Geniposide (Gen) on IA, which has protective impact cells cardiovascular diseases. IA mouse models were administered intraperitoneal injections geniposide for 2 weeks following elastase injection into right basal ganglia brain intervention. The efficacy Gen in...
Coxsackievirus A12 (CVA12) is an enterovirus that has been isolated in many countries recent years. However, studies on CVA12 are limited, and its effective population size, evolutionary dynamics recombination patterns have not clarified now. In this study, we described the phylogenetic characteristics of 16 strains from pediatric HFMD patients mainland China 2010 to 2019. Comparison nucleotide sequences amino acid with prototype strain revealed identical 78.8-79% 94-94.2%, respectively. A...
To understand the practitioners will and influencing factors of junior college clinical medical students in Yunnan Province, extracting 1800 who studied at six higher colleges Province by using stratified cluster sampling method as investigation object. The field survey was conducted through questionnaire interview outline, including inauguration will, career planning, so on. results showed that 17.7% are not willing to work rural primary institutions after graduation, 14.8% be a general...
Echovirus, a member of the Enterovirus B (EV-B) family, has led to numerous outbreaks and pandemics, causing broad spectrum diseases. Based on national hand, foot, mouth disease (HFMD) surveillance system, seven strains echovirus 33 (E33) were isolated from Mainland China between 2010 2018. The whole genomes these sequenced, phylogenetic trees constructed based gene sequences in different regions EV-B prototype strains. It was found that E33 may be recombined P2 P3 regions. Five genotypes...