A5039479036- Antibiotic Resistance in Bacteria
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Salmonella and Campylobacter epidemiology
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Respiratory viral infections research
- Vibrio bacteria research studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Animal Disease Management and Epidemiology
- Escherichia coli research studies
- Cancer Genomics and Diagnostics
- Bacterial biofilms and quorum sensing
- Glioma Diagnosis and Treatment
- Image Retrieval and Classification Techniques
- Bacteriophages and microbial interactions
- Genetic factors in colorectal cancer
- Acute Myeloid Leukemia Research
- Cholesterol and Lipid Metabolism
- Multimodal Machine Learning Applications
- Viral Infections and Vectors
- Immune Response and Inflammation
- Domain Adaptation and Few-Shot Learning
- Pain Mechanisms and Treatments
- Animal Virus Infections Studies
Baylor College of Medicine
2022-2024
Baylor Genetics
2022-2024
Yunnan Center for Disease Control And Prevention
2016-2024
Yantai University
2024
Shandong Academy of Agricultural Sciences
2020-2023
State Key Laboratory of Crystal Materials
2023
Shandong University
2023
Northwestern Polytechnical University
2022
Children's Hospital of Philadelphia
2018-2022
Nanjing University
2022
Perceptual image quality metrics have explicitly accounted for human visual system (HVS) sensitivity to subband noise by estimating just noticeable distortion (JND) thresholds. A recently proposed class of metrics, known as structural similarity (SSIM), models perception implicitly taking into account the fact that HVS is adapted extracting information from images. We evaluate SSIM and compare their performance traditional approaches in context realistic distortions arise compression error...
Neurotrophic tyrosine receptor kinase (NTRK) fusions have been described as oncogenic drivers in a variety of tumors. However, little is known about the overall frequency NTRK fusion unselected pediatric Here, we assessed frequency, partners, and clinical course patients with fusion-positive tumors.We studied 1,347 consecutive tumors from 1,217 who underwent tumor genomic profiling using custom-designed DNA RNA next-generation sequencing panels. identified were orthogonally confirmed.NTRK 29...
Vibrio cholerae quorum sensing controls expression of four redundant sRNAs, Qrr1-4. The Qrr sRNAs are predicted to alter the translation several mRNAs, including, hapR, which encodes a transcription factor that genes for virulence factors, biofilm formation, protease production and DNA uptake. Each contains 21 nucleotide region absolutely conserved among pathogenic Vibrios, base pair with mRNA targets, like aided by RNA chaperone Hfq. This molecular mechanism was not experimentally tested...
Clinical exome sequencing (CES) has a reported diagnostic yield of 20% to 30% for most clinical indications. The ongoing discovery novel gene-disease and variant-disease associations are expected increase the CES. Performing systematic reanalysis previously nondiagnostic CES samples represents significant challenge laboratories. Here, we present results automated methodology applied 300 initially analyzed between June 2014 September 2016. Application our reduced variant analysis burden by...
H5N6 avian influenza virus (AIV) has caused sporadic, recurring outbreaks in China and Southeast Asia since 2013, with 19 human infections 13 deaths. Seventeen of these occurred December 2015, indicating a recent rise the frequency cases. To assess relative threat to humans, we summarized compared clinical data from patients infected (n = 19) against 2 subtypes major public health concern, H5N1 53) H7N9 160). immune responses indicative prognosis, concentrations serum cytokines/chemokines...
A total of 154 non-duplicate Salmonella isolates were recovered from 1,105 rectal swabs collected three large-scale chicken farms (78/325, 24.0%), duck (56/600, 9.3%) and pig (20/180, 11.1%) between April July 2016. Seven serotypes identified among the isolates, with most common serotype in chickens ducks being enteritidis pigs typhimurium. Antimicrobial susceptibility testing revealed that high antimicrobial resistance rates observed for tetracycline (72.0%) ampicillin (69.4%) all sources....
The liver plays a central role in cholesterol homeostasis. It exclusively receives and metabolizes oxysterols, which are important metabolites of more cytotoxic than free cholesterol, from all extrahepatic tissues. Hepatocellular carcinomas (HCCs) impair certain functions cause pathological alterations many processes including metabolism. However, the link between an altered metabolism HCC development is unclear. Human ACAT2 abundantly expressed intestine fetal liver. Our previous studies...
Gallbladder cancer (GBC) is the most common malignancy in biliary tract with poor prognosis. Due to its high chemoresistance, systemic chemotherapies have had limited success treating GBC patients. MicroRNAs (miRNAs) are emerging novel regulators of which modulate expression drug resistance-related genes. In this study, we investigated association between miR-145 and cisplatin sensitivity by both vivo vitro analysis. Quantitative PCR (q-PCR) analysis indicated an increased tissues. addition,...
Abstract Dysembryoplastic neuroepithelial tumors (DNT) lacking key diagnostic criteria are challenging to diagnose and sometimes fall into the broader category of mixed neuronal-glial (MNGT) or recently described polymorphous low-grade tumor young (PLNTY). We examined 41 patients with DNT, MNGT, PLNTY for histologic features, genomic findings, progression-free survival (PFS). Genomic analysis included sequence copy number variants RNA-sequencing. Classic DNT (n = 26) was compared those...
Salmonella spp. are one of the most important foodborne bacterial pathogens in human beings and animals. This study aimed to analyze prevalence characterization from broilers Shandong, China. A total 67 were recovered 600 rectal swabs collected 3 large-scale intensive broiler farms (67/600, 11.2%) between May October 2018. Among isolates, common serovars S. enteritidis typhimurium. The highest occurrence resistance observed was for polymyxin (100%), followed by ampicillin (68.7%)....
This study was aimed to investigate the effects of Clostridium butyricum (C. butyricum) immunity and intestinal epithelial barrier function at mucosal level, by using Salmonella enteritidis (S. enteritidis) infect specific-pathogen-free (SPF) chickens cells (IEC). We found that C. could decrease cytokine levels (IFN-γ, IL-1β, IL-8 TNF-α) via TLR4-, MyD88-, NF-κB-dependent pathways in tissues cells. Additionally, attenuate bacteria-induced damage increase expression level muc-2 ZO-1 intestine...
Spammers are constantly creating sophisticated new weapons in their arms race with anti-spam technology, the latest of which is image-based spam. The newest spam uses simple image processing technologies to vary content individual messages, e.g. by changing foreground colors, backgrounds, font types, or even rotating and adding artifacts images. Thus, they pose great challenges conventional filters. In this paper, we propose a system using probabilistic boosting tree determine whether an...
Summary Biofilms promote attachment of V ibrio cholerae in aquatic ecosystems and aid transmission. Intracellular c‐di‐ GMP levels that control biofilm development positively correlate with expression Q rr sRNAs , which are transcribed when quorum sensing ( QS ) autoinducer low. The base‐pair repress translation hapR encoding the ‘master regulator’, hence increased at low density were believed to be solely a consequence rr/ pairing. We show also activate mRNA diguanylate cyclase DGC ),...
The current study aimed to analyze the prevalence and characterization of
Salmonella has been considered as one of the most important foodborne pathogens that threatened breeding industry and public health. To investigate prevalence characterization isolated from duck farms a slaughterhouse in Shandong province, total 49 strains were 2342 samples four Jinan Tai'an, China.Among isolates, S. Enteritidis (20/49, 40.8%) Anatum (10/49, 20.4%) prevalent, high resistance rates detected for erythromycin (49/49, 100.0%) nalidixic acid (47/49, 95.9%). Class I integrons 17...
Antibiotic resistance genes of Escherichia coli (E. coli) from companion animals were still poorly understood. Here, we investigated the extended-spectrum β-lactamases (ESBLs) E. in Shandong, China. A total 79 isolates (80.6%) recovered 98 healthy or diarrheal 2021, among which ESBLs-producing accounted for 43.0% (34/79), and more than half ESBL (ESBL-EC) strains (n = 19) isolated animals. Diarrheagenic (45.6%, n 36) represented by enterotoxigenic (ETEC) (32.9%), enteropathogenic (EPEC)...
Clinical next-generation sequencing is an effective approach for identifying pathogenic sequence variants that are medically actionable participants and families but not associated with the participant's primary diagnosis. These called secondary findings (SFs). According to literature, there no report of types frequencies SFs in a large pediatric cohort includes substantial African-American participants. We sought investigate (including American College Medical Genetics Genomics [ACMG]...
Benzoic acid as a dietary supplement mitigates inflammation and intestinal injury in acute enterotoxigenic Escherichia coli -infected mice without adverse effects healthy mice.
Humans express two ACAT (acyl-CoA:cholesterol acyltransferase) genes, ACAT1 and ACAT2. is ubiquitously expressed, whereas ACAT2 primarily expressed in intestinal mucosa plays an important role cholesterol absorption. To investigate the molecular mechanism(s) responsible for tissue-specific expression of ACAT2, we identified five cis-elements within human promoter, four intestinal-specific transcription factor CDX2 (caudal type homeobox 2), one HNF1α (hepatocyte nuclear 1α). Results...
Traditional image similarity metrics compare two images on a point-by-point basis. On the other hand, structural (SSIM) attempt to base "structural" information. We evaluate performance of SSIM in context texture similarity, and propose new that incorporate best features eliminate most serious drawbacks. show proposed outperform its variations, as well PSNR traditional metrics. demonstrate advantages carefully selected set 39 pairs comparisons with informal subjective test results.