A5101567025- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- COVID-19 Clinical Research Studies
- Ferroptosis and cancer prognosis
- Esophageal Cancer Research and Treatment
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Genetic factors in colorectal cancer
- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- Viral gastroenteritis research and epidemiology
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- SARS-CoV-2 detection and testing
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Telomeres, Telomerase, and Senescence
- RNA modifications and cancer
- Advanced Electron Microscopy Techniques and Applications
- Amino Acid Enzymes and Metabolism
- Cell death mechanisms and regulation
Henan University
2020-2024
Jilin University
2020-2024
Huashan Hospital
2024
Fudan University
2023-2024
State Key Laboratory of Medical Neurobiology
2023
Weatherford College
2023
Shanghai Stomatological Hospital
2023
Children's Hospital of Fudan University
2023
Jiangsu University
2023
Affiliated Hospital of Jiangsu University
2023
Coronavirus disease 2019 (COVID-19) is a pandemic with no specific therapeutic agents and substantial mortality. It critical to find new treatments.To determine whether convalescent plasma transfusion may be beneficial in the treatment of critically ill patients severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Case series 5 laboratory-confirmed COVID-19 distress (ARDS) who met following criteria: pneumonia rapid progression continuously high viral load despite antiviral...
Abstract Mutations that inactivate negative translation regulators cause autism spectrum disorders (ASD), which predominantly affect males and exhibit social interaction communication deficits repetitive behaviors. However, the cells ASD through elevated protein synthesis resulting from these mutations remain unknown. Here we employ conditional overexpression of initiation factor eIF4E to increase in specific brain cells. We show exaggerated microglia, but not neurons or astrocytes, leads...
Abstract Chemotherapy is a primary treatment for esophageal squamous cell carcinoma (ESCC). Resistance to chemotherapeutic drugs an important hurdle effective treatment. Understanding the mechanisms underlying chemotherapy resistance in ESCC unmet medical need improve survival of ESCC. Herein, we demonstrate that ferroptosis triggered by inhibiting high mobility group AT-hook 1 (HMGA1) may provide novel opportunity gain therapeutic strategy against chemoresistance HMGA1 upregulated and works...
Despite the confirmed role of LKB1 in suppressing lung cancer progression, its precise effect on cellular senescence is unknown. The aim this research was to clarify and mechanism restraining telomerase activity adenocarcinoma. results showed that induced apoptosis either vitro or vivo. Overexpression LKB1-deficient A549 cells led inhibition induction telomere dysfunction by regulating reverse transcriptase (TERT) expression terms transcription. As a transcription factor, Sp1 mediated TERT...
Abstract Caspase-2 is the most evolutionarily conserved member in caspase family of proteases and constitutively expressed cell types including neurons; however, its physiological function remains largely unknown. Here we report that caspase-2 plays a critical role synaptic plasticity cognitive flexibility. We found deficiency led to deficits dendritic spine pruning, internalization AMPA receptors long-term depression. Our results indicate degrades Rictor, key mTOR complex 2 (mTORC2)...
Abstract Background O-GlcNAcylation modification affects multiple physiological and pathophysiolocal functions of cells. Altered was reported to participate in antivirus response. Stimulator interferon genes (STING) is an adaptor mediating DNA virus-induced innate immune Whether STING able be modified by how STING-mediated anti-DNA virus response remain unknown. Methods Metabolomics analysis used for detecting metabolic alterations HSV-1 infection Succinylated wheat germ agglutinin (sWGA),...
Anxiety disorders are associated with body weight changes in humans. However, the mechanisms underlying anxiety-induced remain poorly understood. Using Emx1Cre/+ mice, we deleted gene for brain-derived neurotrophic factor (BDNF) cortex, hippocampus, and some amygdalar subregions. The resulting mutant mice displayed impaired GABAergic transmission elevated anxiety. They were leaner when fed either a chow diet or high-fat diet, owing to higher sympathetic activity, basal metabolic rate, brown...
Deficiency in T cell-mediated adaptive immunity, such as low CD8+ cell infiltration, inhibits the immune surveillance, promotes malignant transformation, and facilitates tumor growth. Microbiota dysbiosis diminishes system contributes to occurrence of cancer. However, impact oral on molecular mechanisms oropharyngeal cancer (OPC) remains largely unknown. In current study, we used 4-nitroquinoline-1-oxide (4NQO) mimic tobacco-related carcinogenesis generate a murine OPC model determine role...
Abdominal irradiation (IR) destroys the intestinal mucosal barrier, leading to severe infection. There is an urgent need find safe and effective treatments reduce IR-induced injury. In this study, we reported that metformin protected mice from abdominal injury by improving composition diversity of flora. The elimination microbiota (Abx) abrogated protective effects on irradiated mice. We further characterized treatment increased murine abundance Lactobacillus, which mediated radioprotective...
Abstract Objective To evaluate the cognitive function of Chinese patients with Parkinson's disease PD postsubthalamic nucleus deep brain stimulation (STN‐DBS). Methods Cognitive was assessed by neuropsychological methods in patients. Twenty matched healthy persons served as normal controls. t test, analysis variance, and chi‐square were used to compare difference among groups. Reliable change index utilized analyze changes cognition from individual level. Results (a) Improvement motor...
During the fifth wave of human H7N9 infections, a novel highly pathogenic (HP) variant emerged with an insertion multiple basic amino acids in HA cleavage site. Moreover, neuraminidase inhibitor (NAI) resistance (R292K NA) mutation was found isolates from humans, poultry and environment. In this study, we set out to develop validate multiplex quantitative reverse transcript polymerase chain reaction (qRT-PCR) simultaneously detect presence further identify HP NAI-resistance mutations. A...
As loss of DNA-repair proteins is common in urothelial carcinoma (UC), a rationale can be made to evaluate the activity poly (ADP-ribose) polymerase (PARP) inhibitors exploit synthetic lethality. We aimed preclinically PARP inhibitor, CEP-9722, and its active metabolite, CEP-8983, UC. The CEP-8983 was evaluated using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay against human UC cell lines. Flow cytometry, COMET assay, western blot were performed assess apoptosis,...
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Mutations of TP53 may reach 70% - 85% in HNSCC patients without human papillomavirus (HPV) infection. Recurrence rate remains particularly high for with mutations gene although are responsive to surgery, irradiation, chemotherapy early treatment. p53-Reactivation Induction Massive Apoptosis-1 (PRIMA-1) its methylated analogue PRIMA-1Met (also known as APR-246) quinuclidine compounds that rescue...
The innate immune system serves as the host's first line of defense against invading pathogens. Stimulator interferon genes (STING) is a key component this system, yet its relationship with glucose metabolism, particularly in antiviral immunity, remains underexplored. Metabolomics analysis was used for detecting metabolic alterations spleens from STING knockout (KO) and wild-type (WT) mice. Co-immunoprecipitation employed determining ubiquitination TKT. Mass spectrometry interaction proteins...
Abstract Background As a complex system participating in tumor development and progression, the microenvironment was poorly understood esophageal cancer especially squamous cell carcinoma (ESCC). Methods ESTIMATE algorithm is used to investigate tumor-infiltrating immune cells prognostic genes which were associated with ESCC. Results Based on stromal scores, ESCC samples divided into high low score groups 299 overlapping differentially expressed identified. Functional enrichment analysis...
Inactivating mutations in the liver kinase B1 (LKB1) tumor suppressor gene underlie Peutz-Jeghers syndrome (PJS) and occur frequently various human cancers. We previously showed that LKB1 regulates centrosome duplication via PLK1. Here, we report further helps to maintain genomic stability through negative regulation of survivin, a member chromosomal passenger complex (CPC) mediates CPC targeting centromere. found loss led accumulation misaligned lagging chromosomes at metaphase anaphase...