A5016487886- Nuclear Receptors and Signaling
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- MicroRNA in disease regulation
- Macrophage Migration Inhibitory Factor
- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- RNA Interference and Gene Delivery
- Diet and metabolism studies
- interferon and immune responses
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- Extracellular vesicles in disease
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Bone health and treatments
- Autophagy in Disease and Therapy
- Genomics, phytochemicals, and oxidative stress
- Galectins and Cancer Biology
- Endometriosis Research and Treatment
Texas A&M University
2022-2025
Shandong Provincial QianFoShan Hospital
2023-2025
Shandong First Medical University
2023-2025
University of Southern California
2025
Mitchell Institute
2025
Henan University
2017-2024
Shaanxi University of Chinese Medicine
2024
City Of Hope National Medical Center
2023-2024
Henan University Huaihe Hospital and Huaihe Clinical Institute
2024
Capital Medical University
2022-2024
Adipose tissue macrophage (ATM) plays a central role in obesity-associated inflammation and insulin resistance. Quercetin, dietary flavonoid, possesses anti-inflammation anti-insulin resistance properties. However, it is unclear whether quercetin can alleviate high-fat diet (HFD)-induced ATM infiltration mice. In this study, 5-week-old C57BL/6 mice were fed low-fat diet, HFD, or HFD with 0.l% for 12 weeks, respectively. Dietary reduced HFD-induced body weight gain improved sensitivity...
Micro-/nanoplastics (MNPLs), novel environmental pollutants, widely exist in the environment and life bring health risks. Previous studies have shown that NMPLs can penetrate bone marrow, but whether they cause hematopoietic damage remains uncertain. In this study, C57BL/6J mice were treated with polystyrene MNPLs (PS-MNPLs, 10 μm, 5 μm 80 nm) at 60 μg doses for 42 days by intragastric administration. We evaluated toxicity induced potential mechanisms via combining 16S rRNA, metabolomics,...
Ferroptosis, implicated in several diseases, is a new form of programmed and nonapoptotic cell death triggered by iron-dependent lipid peroxidation after inactivation the cystine/glutamate antiporter system xc – , which composed solute carrier family 7 membrane 11 (SLC7A11) 3 2 (SLC3A2). Therefore, inducing ferroptosis through inhibiting may be an effective way to treat cancer. In previous screening tests, we found that benzopyran derivative 2-imino-6-methoxy-2H-chromene-3-carbothioamide...
Peripheral nerve injury usually leads to poor outcomes such as painful neuropathies and disabilities. Autogenous grafting is the current gold standard; however, limited source of a donor remains problem. Numerous tissue engineering guidance conduits have been developed substitutes for autografts. However, few can achieve reparative effect equivalent Here, we report development application carbon nanotube (CNT)/sericin conduit with electrical conductivity suitable mechanical properties...
Blood transferrin receptor-positive (TfR+) exosomes are a kind of optimized drug delivery vector compared with other kinds due to their easy access and high bio-safety. Their application facilitates the translation from bench bedside exosome-based vehicles. Methods: In this study, pH-responsive superparamagnetic nanoparticles cluster (denoted as SMNC)-based method was developed for precise mild separation blood TfR+ exosomes. Briefly, multiple (SPMNs) labeled transferrins (Tfs) could...
Abstract Chemotherapy is a primary treatment for esophageal squamous cell carcinoma (ESCC). Resistance to chemotherapeutic drugs an important hurdle effective treatment. Understanding the mechanisms underlying chemotherapy resistance in ESCC unmet medical need improve survival of ESCC. Herein, we demonstrate that ferroptosis triggered by inhibiting high mobility group AT-hook 1 (HMGA1) may provide novel opportunity gain therapeutic strategy against chemoresistance HMGA1 upregulated and works...
Abstract Receptor-interacting protein kinase 3 (RIPK3), a member of the receptor-interacting (RIPK) family with serine/threonine activity, interacts RIPK1 to generate necrosomes, which trigger caspase-independent programmed necrosis. As vital component RIPK3 plays an indispensable role in necroptosis, is crucial for human life and health. In addition, participates pathological process several infections, aseptic inflammatory diseases, tumors (including tumor-promoting -suppressive...
Base excision repair (BER) handles many forms of endogenous DNA damage, and apurinic/apyrimidinic endonuclease 1 (APE1) is central to this process. Deletion both alleles APE1 (a.k.a. Apex1) in mice leads embryonic lethality, deficiency cells can promote cell death. Unlike most other BER proteins, expression inversely correlated with cellular senescence primary human fibroblasts. Depletion via shRNA induced normal BJ fibroblasts, a phenotype that was not seen counterpart expressing...
To construct effective electromagnetic parameters of reduced graphene oxide (RGO)-based composites for lightweight and high efficiency microwave absorption, Ni/RGO were prepared via a facile in-situ hydrothermal process. Due to the strong high-frequency polarization effect related large surface contact area obtained hybrids, presented wave attenuation ability even when filler content is only 1.6 wt. %. This work might deepen understanding dielectric loss mechanism impedance matching provide...
Due to the annual increase in its production and consumption occupational environments, adverse blood outcomes caused by benzene are of concern. However, mechanism benzene-induced hematopoietic damage remains elusive. Here, we report that exposure causes a dose-dependent manner is associated with disturbances gut microbiota-long chain fatty acids (LCFAs)-inflammation axis. C57BL/6J mice exposed for 45 days were found have significant reduction whole cells suppression hematopoiesis, an...
Osteosarcoma (OS) is the most common primary bone malignancy because of its extra high tendency metastasis. In-depth research needed to uncover pathogenesis patients with OS cells. We collected 74 tissue samples from cells and measured expression levels ghrelin by immunohistochemistry. Ghrelin was added into cell lines in CCK8 assays, JC-1 staining Western blot analysis were performed explore effect on aggressiveness drug resistance. To determine function, overexpressed or knocked down then...
Polyfluoroalkyl substances (PFAS) are widely used industrial compounds that have been identified as contaminants in almost every component of the global ecosystem, and human studies, higher levels PFAS correlated with increased incidence multiple diseases. Based on results laboratory animal we hypothesize orphan nuclear receptor 4A1 (NR4A1) may be a critical target for some such legacy linear polyfluorooctanesulfonate (PFOS) other sulfonates. We show PFOS related bound ligand binding domain...