A5101728901- Advanced ceramic materials synthesis
- RNA modifications and cancer
- Cancer-related gene regulation
- Acupuncture Treatment Research Studies
- PI3K/AKT/mTOR signaling in cancer
- Fungal Plant Pathogen Control
- Mycotoxins in Agriculture and Food
- Diamond and Carbon-based Materials Research
- Epigenetics and DNA Methylation
- Plant Pathogens and Fungal Diseases
- Nematode management and characterization studies
- Advanced materials and composites
- Surface Modification and Superhydrophobicity
- Metal and Thin Film Mechanics
- Boron and Carbon Nanomaterials Research
- Algal biology and biofuel production
- Plant biochemistry and biosynthesis
- Medicinal Plant Pharmacodynamics Research
- Biochemical Analysis and Sensing Techniques
- Psychosomatic Disorders and Their Treatments
- Advanced biosensing and bioanalysis techniques
- Healthcare and Venom Research
- High-pressure geophysics and materials
- Wnt/β-catenin signaling in development and cancer
- Regulation of Appetite and Obesity
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Shandong First Medical University
2023-2025
Shandong Provincial QianFoShan Hospital
2025
Hangzhou Normal University
2011-2024
Jilin Academy of Agricultural Sciences
2024
First Institute of Oceanography
2016-2024
Ministry of Natural Resources
2024
Peng Cheng Laboratory
2024
Huazhong University of Science and Technology
2013-2024
Fudan University
2023
Mobile cloud computing, with its promise to meet the urgent need for richer applications and services of resource-constrained mobile devices, is emerging as a new computing paradigm has recently attracted significant attention. However, there no clear definition well defined scope due commercial hype, diverse ways combining applications. This article makes first attempt present survey from perspective intended usages. Specifically, we introduce three common architectures classify...
Aberrant lysine lactylation (Kla) is associated with various diseases which are caused by excessive glycolysis metabolism. However, the regulatory molecules and downstream protein targets of Kla remain largely unclear. Here, we observed a global abundance profile in colorectal cancer (CRC) that negatively correlates prognosis. Among lactylated proteins detected CRC, eEF1A2K408 resulted boosted translation elongation enhanced synthesis contributed to tumorigenesis. By screening eEF1A2...
Perfluorooctane acid (PFOA) is a hazardous environmental pollutant that has been reported to exert adverse effects on animal and human health. In this study, male mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day) evaluate the reproductive toxicity. Exposure for 14 consecutive days obviously disrupted seminiferous tubules reduced sperm count. The highest concentration (10 caused growth retardation diminished absolute testis weight. Furthermore, treatment...
We report an approach to strengthen micro-grained polycrystalline diamond (MPD) compact through work hardening under high pressure and temperature, in which both hardness fracture toughness are simultaneously boosted. Micro-sized powders treated without any additives a of 14 GPa temperatures ranging from 1000 °C 2000 °C. It was found that the temperature environments could constrain brittle feature cause severe plastic deformation starting grains form mutual bonded network. The relative...
CTNNB1 , encoding β-catenin protein, is the most frequently altered proto-oncogene in hepatic neoplasms. In this study, we studied significance and pathological mechanism of gain-of-function mutations hepatocarcinogenesis. Activated not only triggered tumorigenesis but also exacerbated Tp53 deletion or hepatitis B virus infection–mediated liver cancer development mouse models. Using untargeted metabolomic profiling, identified boosted de novo pyrimidine synthesis as major metabolic...
A quantum dot-based FRET method was established for a highly sensitive detection of DNA methylation levels.
Abstract Colorectal cancer (CRC) is one of the most commonly diagnosed and deadly malignant tumors globally, its occurrence progression are closely related to poor histological features complex molecular characteristics among patients. It urgent identify specific biomarkers for effective treatment CRC. In this study, we performed comprehensive experiments validate role xCT expression in CRC tumorigenesis stemness confirmed knockdown significantly suppressed proliferation, migration, cells...
Abstract Background Although hepatitis B virus (HBV) infection is a major risk factor for hepatic cancer, the majority of HBV carriers do not develop this lethal disease. Additional molecular alterations are thus implicated in process liver tumorigenesis. Since phosphatase and tensin homolog (PTEN) decreased approximately half cancers, we investigated significance PTEN deficiency HBV-related hepatocarcinogenesis. Methods HBV-positive human cancer tissues were checked expression. Transgenic ,...
BACKGROUND: Atherosclerosis is a chronic inflammatory disease. GOLM1 (Golgi membrane protein 1) an inflammation-responsive and mediator in some inflammation-associated pathological processes. Because we found positive correlation between expression atherosclerosis progression by checking the gene data set of human atherosclerotic lesions, explored potential significance this study. METHODS: levels serums lesions patients with mice were examined immunostaining ELISA. Gain-of-function...
Osteosarcoma (OS) is the most common primary bone malignancy because of its extra high tendency metastasis. In-depth research needed to uncover pathogenesis patients with OS cells. We collected 74 tissue samples from cells and measured expression levels ghrelin by immunohistochemistry. Ghrelin was added into cell lines in CCK8 assays, JC-1 staining Western blot analysis were performed explore effect on aggressiveness drug resistance. To determine function, overexpressed or knocked down then...
Rationale: Although β-catenin is frequently activated in various cancers, no targeted therapies have been approved for clinical use. Methods: High-throughput drug screening was performed to identify potential compounds against β-catenin-activated tumors. The efficacy of identified assessed orthotopic β-catenin-driven hepatocellular carcinoma model mice. Results: OSI-027 emerged as the most potent agent that selectively inhibited β-catenin-mutant cells. Mechanistically, enhanced transcription...
Small language models (SLMs), despite their widespread adoption in modern smart devices, have received significantly less academic attention compared to large model (LLM) counterparts, which are predominantly deployed data centers and cloud environments. While researchers continue improve the capabilities of LLMs pursuit artificial general intelligence, SLM research aims make machine intelligence more accessible, affordable, efficient for everyday tasks. Focusing on transformer-based,...