A5103120129- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Mesenchymal stem cell research
- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Neuropeptides and Animal Physiology
- Advanced Drug Delivery Systems
- Carcinogens and Genotoxicity Assessment
- Reproductive System and Pregnancy
- Traditional Chinese Medicine Analysis
- Pesticide Exposure and Toxicity
- Ginseng Biological Effects and Applications
- Cardiac Ischemia and Reperfusion
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA Interference and Gene Delivery
- Trace Elements in Health
- Synthesis and Biological Evaluation
- Microbial metabolism and enzyme function
- Advancements in Transdermal Drug Delivery
- Quinazolinone synthesis and applications
- Heme Oxygenase-1 and Carbon Monoxide
- Acute Ischemic Stroke Management
- Pharmacological Effects of Medicinal Plants
- Free Radicals and Antioxidants
Gansu Research Academy of Forestry Science and Technology
2025
Nanchang University
2009-2022
Central China Normal University
2016-2020
Tianjin University of Science and Technology
2013
China Pharmaceutical University
2009-2010
Selenocysteine (Sec), encoded as the 21st amino acid, is predominant chemical form of selenium that closely related to various human diseases. Thus, it high importance identify novel probes for sensitive and selective recognition Sec Sec-containing proteins. Although a few have been reported detect artificially introduced selenols in cells or tissues, none them has shown be enough endogenous selenols. We report characterization application new fluorogenic molecular probe detection...
Perfluorooctanoic acid (PFOA) is widely present in the environment and has been reported to induce hepatic toxicity animals humans. In this study, mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day). Histological examination showed that exposure for 14 consecutive days led serious hepatocellular injury obvious inflammatory cell infiltration. addition, malondialdehyde formation hydrogen peroxide generation, indicators oxidative stress, significantly...
Perfluorooctane acid (PFOA) is a hazardous environmental pollutant that has been reported to exert adverse effects on animal and human health. In this study, male mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day) evaluate the reproductive toxicity. Exposure for 14 consecutive days obviously disrupted seminiferous tubules reduced sperm count. The highest concentration (10 caused growth retardation diminished absolute testis weight. Furthermore, treatment...
4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) has been identified as one of the most significant targets in herbicide discovery for resistant weed control. In a continuing effort to discover potent novel HPPD inhibitors, we adopted ring-expansion strategy design series pyrazole–quinazoline-2,4-dione hybrids based on previously discovered pyrazole–isoindoline-1,3-dione scaffold. One compound,...
Background: Scientific and rational fertilizer management can not only improve the yield quality of hazelnut (Corylus heterophylla × Corylus avellana) but also reduce negative impact on environment. Methods: Liquid Chromatography–tandem Mass Spectrometry (LC-MS/MS) technology was used to reveal contents various metabolites in seedlings, differential were screened by principal component analysis (PCA) partial least squares discriminant (PLS-DA). Results: The results showed that a total 178...
Abstract Grape seed proanthocyanidin extract (GSPE) is a rich source of proanthocyanidins with multiple biological activities and potential health benefits. In the present study, we investigated protective effect GSPE against liver injury caused by perfluorooctanoic acid (PFOA) in mice its possible mechanisms action. Simultaneous treatment for 14 consecutive days attenuated functional morphological changes PFOA-exposed mice. Furthermore, simultaneous supplementation reduced production...
SUMMARY The androgen receptor (AR) is a ligand‐activated transcription factor that important for both the male and female reproductive systems. expression regulation of AR in uterine endometrium during early pregnancy decidualization remain relatively under‐investigated, so we sought to immunohistochemically examine spatiotemporal mouse uteri peri‐implantation period as well response specific steroid hormones. protein was found nuclei stromal cells starting on Days 1 2, with its abundance...
Perfluorooctane sulfonate (PFOS), an environmentally persistent pollutant, has been revealed to elicit hepatic toxicity. In the current study, we investigated protective role of grape seed proanthocyanidin extract (GSPE) against PFOS-caused steatohepatitis in mice. Animals were exposed intragastrically PFOS (10 mg/kg/day), GSPE (150 or their combination. After 21 days treatment, mice exhibited steatosis, oxidative stress, and inflammation liver. Nevertheless, simultaneous administration...
Quercetin treatment attenuated PFOA-induced oxidative stress and apoptosis in the testes of mice.
Abstract A sensitive and specific liquid chromatographic–electrospray ionization mass spectrometric method was developed for quantification of salvianolic acid B in rat plasma with resveratrol as the internal standard. The analytes were separated on a reversed‐phase column acetonitrile (40%) water (60%) containing 0.75% formic mobile phase at flow rate 1 mL/min. Liquid–liquid extraction adopted sample preparation, determined using electrospray negative spectrometry selective monitoring mode....
Background: Considering the chronic and repeated nature of salmon calcitonin (sCT) therapy, oral route is a preferred administration. But, bioavailability sCT very low due to enzymatic degradation poor permeation across intestinal epithelial cells. It was aim this study investigate pharmacodynamic (PD), pharmacokinetic (PK), mucosal injury characteristic delivery system. Method: In study, PD experiments were performed find suitable releasing region sCT, an effect absorption enhancer, optimal...
Considering the chronic and repeated nature of salmon calcitonin (sCT) therapy, oral route is a preferred administration. But, bioavailability sCT very low due to enzymatic degradation poor permeation across intestinal epithelial cells. It was aim this study investigate pharmacodynamic (PD), pharmacokinetic (PK), mucosal injury characteristic delivery system.In study, PD experiments were performed find suitable releasing region sCT, an effect absorption enhancer, optimal mass ratio...
Bone marrow stem cells (BMSCs) have the capacity to differentiate into mature cell types of multiple tissues. Thus, they represent an alternative source for organ-specific replacement therapy in degenerative diseases. In this study, we demonstrated that female rat BMSCs could steroidogenic with de novo synthesis Estradiol-17 β (E2) under high glucose culture conditions or without retinoic acid (RA). The cultured express mRNA and protein P450arom, enzyme responsible estrogen biosynthesis....
Abstract Background The temporal relationship between Short-chain fatty acids (SCFAs) and hypertensive disorders of pregnancy (HDP) is unclear. This study aimed to examine the probable causal them. Methods A nested case-control including 387 pairs cases with HDP healthy controls was conducted. Seven SCFAs levels in plasma samples drawn at 16-20 gestational weeks before were assayed by GC/MS. individual joint associations examined logistic regression weighted quantile sum (WQS) regression,...