A5047645060- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Effects and risks of endocrine disrupting chemicals
- Apelin-related biomedical research
- Per- and polyfluoroalkyl substances research
- Ovarian function and disorders
- Paraoxonase enzyme and polymorphisms
- Toxic Organic Pollutants Impact
- Birth, Development, and Health
- Air Quality and Health Impacts
- Reproductive Biology and Fertility
- Hypothalamic control of reproductive hormones
- Cynara cardunculus studies
- Nuclear Receptors and Signaling
- MicroRNA in disease regulation
- Endometriosis Research and Treatment
- Estrogen and related hormone effects
- Potato Plant Research
- Sperm and Testicular Function
- Pesticide Exposure and Toxicity
- Microplastics and Plastic Pollution
- Cancer Risks and Factors
- Reproductive Physiology in Livestock
- Kruppel-like factors research
- 3D Printing in Biomedical Research
Nanchang University
2015-2024
State Key Laboratory of Food Science and Technology
2014
Chinese Academy of Sciences
2008-2010
Institute of Zoology
2009-2010
University of Chinese Academy of Sciences
2009-2010
First Affiliated Hospital of Jiangxi Medical College
2003
Plastic particle pollution poses an emerging threat to ecological and human health. Laboratory animal studies have illustrated that nano-sized plastics can accumulate in the testis cause testosterone deficiency spermatogenic impairment. In this study, TM3 mouse Leydig cells were vitro exposed polystyrene nanoparticles (PS-NPs, size 20 nm) at dosages of 50, 100 150 μg/mL investigate their cytotoxicity. Our results demonstrated PS-NPs be internalized into led a concentration-dependent decline...
Human embryonic stem cells (ESCs [hESCs]) proliferate as colonies wherein individual are strongly adhered to one another. This architecture is linked hESC self-renewal, pluripotency, and survival depends on epithelial cadherin (E-cadherin), NMMIIA (nonmuscle myosin IIA), p120-catenin. E-cadherin p120-catenin work within a positive feedback loop that promotes localized accumulation of at intercellular junctions. stabilizes protein controls E-cadherin–mediated adhesion. Perturbations this...
Titanium dioxide nanoparticles (TiO2 NPs) have recently found applications in a wide variety of consumer goods. TiO2 NPs exposure significantly increases fetal deformities and mortality. However, the potential toxicity on growth development placenta has been rarely studied during mice pregnancy.The objective this study was to investigate effects maternal placentation.Mice were administered by gavage at 0, 1 10 mg/kg/day from gestational day (GD) GD 13. Uteri placentas these collected counted...
Perfluorooctanoic acid (PFOA) is widely present in the environment and has been reported to induce hepatic toxicity animals humans. In this study, mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day). Histological examination showed that exposure for 14 consecutive days led serious hepatocellular injury obvious inflammatory cell infiltration. addition, malondialdehyde formation hydrogen peroxide generation, indicators oxidative stress, significantly...
Plasma kisspeptin levels dramatically increased during the first trimester of human pregnancy, which is similar to pregnancy specific glycoprotein-human chorionic gonadotropin. However, its particular role in implantation and decidualization has not been fully unraveled. Here, study was conducted investigate expression function mouse uterus early decidualization.Quantitative PCR results demonstrated that Kiss1 GPR54 mRNA showed dynamic increase artificially induced vivo. KISS-1 proteins were...
Nanoplastic contamination has been of intense concern by virtue the potential threat to human and ecosystem health. Animal experiments have indicated that exposure nanoplastics (NPs) can deposit in liver contribute hepatic injury. To explore mechanisms hepatotoxicity induced polystyrene-NPs (PS-NPs), mice AML-12 hepatocytes were exposed different dosages 20 nm PS-NPs this study. The results illustrated vitro vivo triggered excessive production reactive oxygen species repressed nuclear factor...
Perfluorooctanoic acid (PFOA) is a widely used perfluorinated compound and known to cause developmental toxicity which includes the increase of resorbed embryo, decrease fetal survival growth retardation. Nevertheless, whether it associated with alteration placental development remains unknown. Pregnant mice were gavaged 0, 2.5, 5, 10 mg PFOA /kg/day from pregnancy day (PD) 1 PD 13. Results showed that exposure markedly decreased weight caused interstitial edema placenta. Laminin staining...
Abstract Well-controlled trophoblast invasion into uterine decidua is a critical process for the normal development of placenta, which tightly regulated by various factors produced within trophoblast-endometrial microenvironment. CXCL14 involved in tumor growth and metastasis, its expression placenta temporally during pregnancy. However, role function human pregnancy not clear. In this study, using RT-PCR through pregnancy, we found that was selectively expressed at early but late...
Abstract Grape seed proanthocyanidin extract (GSPE) is a rich source of proanthocyanidins with multiple biological activities and potential health benefits. In the present study, we investigated protective effect GSPE against liver injury caused by perfluorooctanoic acid (PFOA) in mice its possible mechanisms action. Simultaneous treatment for 14 consecutive days attenuated functional morphological changes PFOA-exposed mice. Furthermore, simultaneous supplementation reduced production...