A5011542557- Chronic Lymphocytic Leukemia Research
- Asthma and respiratory diseases
- Animal health and immunology
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disorders and Treatments
- Cancer-related molecular mechanisms research
- Peroxisome Proliferator-Activated Receptors
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Food Allergy and Anaphylaxis Research
- Metabolomics and Mass Spectrometry Studies
- Pancreatic and Hepatic Oncology Research
- Mesenchymal stem cell research
- IL-33, ST2, and ILC Pathways
- Neurogenesis and neuroplasticity mechanisms
- Allergic Rhinitis and Sensitization
- Biochemical and Molecular Research
- Cellular Mechanics and Interactions
- S100 Proteins and Annexins
- Nerve injury and regeneration
- Endodontics and Root Canal Treatments
- NF-κB Signaling Pathways
Jiangxi Provincial People's Hospital
2009-2020
Nanchang University
2020
First Affiliated Hospital of Gannan Medical University
2011
An increase in the morbidity of upper respiratory tract infections and attack exacerbation autoimmune diseases has been observed to occur few days following sudden environmental temperature decreases, but mechanisms for these phenomena are not well understood. To determine effect a ambient drop on levels stress hormones T‑lymphocyte cytokines plasma, Toll‑like receptor 4 (TLR4) expression immunocompetent cells rat spleens regulatory T (Treg) peripheral blood, Sprague Dawley rats were divided...
Previous studies have demonstrated that microRNA (miR)-205-5p expression is significantly increased in non‑small cell lung cancer tissues and associated with tumor differentiation grade. The aim of the present study was to explore effects miR‑205‑5p on viability, apoptosis invasion A549 cells. hsa‑miR‑205‑5p small interfering RNA (siRNA) inhibitor transfected into cells detected by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). Cell were assayed Counting kit‑8,...
Rhizoma Atractylodis macrocephalae have an important role in treating cerebrovascular diseases Traditional Chinese Medicine (TCM). The purpose of the present study was to determine neuroprotective effect macrocephalaon polysaccharides (AMPS) on hypoxia‑induced apoptosis cerebral cortical neurons. Neuronal cells obtained from neonatal rats were divided into following groups: Normal control (group C); positive induced by hypoxia‑reoxygenation culture rat primary neurons A); treated with 0.025...
This study aims to determine whether the combined blockade of IL-1β and TNF-α can alleviate pathological allergic inflammatory reaction in nasal mucosa lung tissues rhinitis (AR) guinea pigs. Healthy pigs treated with saline were used as healthy controls. The AR randomly divided into (1) model group intranasal saline; (2) 0.1% nonspecific IgY treatment group; (3) anti-TNF-α (4) anti-IL-1β (5) (6) fluticasone propionate group. cells evaluated using Wright's staining. Histopathology was...
In this study, the use of serum thymidine kinase 1 protein (STK1p) concentration for prognosis overall survival patients with locally advanced breast cancer (n=51) following routine treatment (neoadjuvant treatment, surgery and chemotherapy) was investigated. The were followed up 44 months STK1p values determined by a high‑sensitivity enhanced chemiluminescence (ECL) dot blot assay. variables investigated in relation to metastasis STK1p, clinical stage, tumor size age, Kaplan‑Meier method,...
The present study aimed to investigate the possible effects and regulatory mechanism of inhibitor nuclear factor‑κB kinase complex β subunit (IKKβ) BMS‑345541 on airway inflammation, remodeling epithelial‑mesenchymal transition (EMT) in an ovalbumin (OVA) exposure asthma model mice. mouse was generated by sensitization challenge with OVA. BMS‑345541/dimethyl sulfoxide (DMSO) administered perorally dairy two therapeutic groups throughout entire OVA process. At 24 h following last challenge,...
It is known that the concentration and activity of DNA precursor enzyme thymidine kinase 1 (TK1) in serum significantly elevated patients with malignancies, as compared levels benign tumours those healthy individuals. For first time, use TK1 a prognostic marker for renal cell carcinoma (RCC) was examined. Serum protein (STK1p) (STK1a) were determined by dot blot chemoluminescence assay radio assay, respectively. There no correlation between STK1p STK1a same sera from 27 RCC patients. Only...
In the middle cerebral artery occlusion model of ischemic injury, inflammation primarily occurs in infarct and peripheral zones. zone, neurons undergo necrosis apoptosis, a large number reactive microglia are present. present study, we investigated pathological changes rat occlusion. Neuronal appeared 12 hours after occlusion, peak neuronal apoptosis 4 to 6 days Inflammatory cytokines play role damage repair Serum intercellular cell adhesion molecule-1 levels were positively correlated with...
Rhizoma Dioscoreae polysaccharides (RDPS) are the primary active ingredient of Dioscoreae, which is a traditional Chinese medicine. RDPS have previously been shown to scavenge reactive oxygen species, and protect against D-galactose-induced mimetic aging. The present study aimed investigate neuroprotective effects hypoxia-induced neuronal cell apoptosis. Neuronal cells harvested from pregnant Sprague-Dawley rats were divided into groups, as follows: i) Normal control group; ii) apoptosis...
The transformation of rat primary glial cells into mesenchymal stem (MSCs) is intriguing as more seed can be harvested. present study aimed to evaluate the effects growth factors, hypoxia and mild hypothermia on MSCs. Rat were induced differentiate by treatment with hypoxia, basic fibroblast factor (bFGF) epidermal (EGF). Immunohistochemistry western blotting then used determine expression levels fibrillary acidic protein (GFAP), nestin, musashi‑1, neuron specific enolase (NSE) neuronal...
This paper describes a culture system which supports the formation of B cell and some T colonies under serum-free conditions in peripheral blood samples normal individuals patients with chronic lymphocytic leukemia (CLL) type. In this system, serum is replaced by bovine albumin, transferrin, cholesterol, insulin catalase or horseradish peroxidase. addition, it necessary to add staphylococcus protein A, mitomycin-treated cells as feeders phytohemagglutinin leukocyte-conditioned medium source...
Development of College Student InformationManagement System is an inevitable trend the current campus information technology and important means.Based on for college students' detailed analysis architecture, main function system basis design, design university student management Web-based.The based network, using .Net SQL database technology, B / S multilayer structure.System interface friendly, simple operation, security scalability, while providing office software interacts with EXCEL...
Objective To investigate the correlation between gtial fibrillary acidic protein （GFAP）, neuron-specific enolase （NSE）, synaptophysin （SYN）, neurite outgrowth inhibitor-A （Nogo-A） expression and neurological outcome in tissue surrounding infarct during recovery after cerebral ischemia-reperfusion injury rats. Methods A 2-hour middle artery occlusion （MCAO） reperfusion model rats was induced by intraluminal suture method. The modified severity score （mNSS） performed at day 28, 35, 42, 49....