A5101464867- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Virus-based gene therapy research
- RNA modifications and cancer
- Cancer-related gene regulation
- Mechanisms of cancer metastasis
- Machine Learning in Bioinformatics
- Cancer Mechanisms and Therapy
- Gene expression and cancer classification
- Epigenetics and DNA Methylation
- Ferrocene Chemistry and Applications
- Nutrition, Genetics, and Disease
- RNA Research and Splicing
- Food Allergy and Anaphylaxis Research
- Cancer-related molecular mechanisms research
- Wnt/β-catenin signaling in development and cancer
- Fractal and DNA sequence analysis
- RNA and protein synthesis mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Cells and Metastasis
- Asthma and respiratory diseases
- Selenium in Biological Systems
- Silk-based biomaterials and applications
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
Matsumoto Dental University
2025
Sichuan University
2012-2024
Hefei First People's Hospital
2024
Shanghai Jiao Tong University
2010-2023
Hainan University
2008-2023
Tianjin Medical University
2018-2022
Shanghai Mental Health Center
2017-2022
State Key Laboratory of Biotherapy
2007-2021
Ruijin Hospital
2019-2021
Hainan Normal University
2021
Polypyrimidine tract-binding protein 1 (PTBP1) is a multi-functional RNA-binding that aberrantly overexpressed in glioma. PTBP1 and its brain-specific homologue polypyrimidine 2 (PTBP2) regulate neural precursor cell differentiation. However, the overlapping non-overlapping target transcripts involved this process are still unclear. To determine why not PTBP2 would promote glial cell-derived tumours, both were knocked down human glioma lines U251 LN229 to role of these proteins...
Aberrant RNA splicing is thought to play a key role in tumorigenesis. The assessment of its specific contributions limited by the complexity information derived from genome-wide array-based approaches. We describe how performing factor-specific comparisons using both tumor and cell line data sets may more readily identify physiologically relevant tumor-specific events. Affymetrix exon array glioblastoma (GBM) samples with defined polypyrimidine tract-binding protein 1 (PTBP1) levels were...
Gene selection based on microarray data, is highly important for classifying tumors accurately. Existing gene schemes are mainly ranking statistics. From manifold learning standpoint, local geometrical structure more essential to characterize features compared with global information. In this study, we propose a supervised method called locality sensitive Laplacian score (LSLS), which incorporates discriminative information into structure, by minimizinglocal within-class and maximizing...
Abstract Background Selenium is an essential trace element in the human body. In epidemiological and clinical studies, Se supplementation significantly reduced incidence of lung cancer individuals with low baseline levels. The significant action selenium based on selenium‐containing protein as a mediator. Of note, previous studies reported that expression selenium‐binding 1 (SELENBP1) was obviously decreased many tissues including non‐small cell (NSCLC). However, its roles origin development...
Stem cells play a critical role in the regeneration process by proliferating and differentiating to form new bone tissue. However, stem tend lose their stemness pluripotency during vitro expansion, resulting reduced capacity after osteogenic induction. Our aim is enhance impact of human umbilical cord-derived mesenchymal stromal (hUC-MSCs) through spontaneous spheroid vitro. The osteogenesis-related genes up-regulated hUC-MSCs can be enhanced spheroids For vivo testing, were transplanted...
To develop a simple and practical model to predict the prognostic survival of non-smoking patients with lung adenocarcinoma by combining general pathological information laboratory hematologic indicators. Cox univariate multivariate analyses were used identify variable A proportional hazards was constructed based on selected variables compare outcomes between high-and low-risk groups validate model's performance. Subsequently, nomogram established systematically evaluate impact prognosis....
SLC34A2 with highest expressions in lung, small intestine and kidney encoded a type 2b sodium-dependent phosphate transporter (NaPi-IIb). In only expressed the apical membrane of II alveolar epithelium cells (ATII cells) played pivotal role during fetal lung development embryonic development. ATII acting as multifunctional stem might transform into NSCLC after undergoing exogenous or endogenous factors. Increasing evidences showed that genes performing critical roles embryogenesis were also...
Bioactivity-guided fractionation of the hot water extract from brown alga Sargassum patens led to isolation a polysaccharide as an antiviral component against herpes simplex viruses which are cause cold sores (HSV-1) and genital (HSV-2). The contained sulfur group that could be present sulfate ester. It is thus sulfated with molecular mass about 424 kDa, designated SP-2a. Gas chromatographic assay showed consisted fucose, galactose, mannose, xylose, glucose, galactosamine. fucose major...
// Xixian Ke 1 , Yue Yuan Chenglin Guo 2 Yan Yang Qiang Pu Xueting Hu Kui Tang Xinmei Luo Qianqian Jiang Xiaolan Su Lunxu Liu Wen Zhu Yuquan Wei State Key Laboratory of Biotherapy and Cancer Center/National Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, Department Thoracic Surgery, Correspondence to: Zhu, email: zhuwen@scu.edu.cn Liu, lunxu_liu@aliyun.com Keywords: miR-410, stemness, Wnt/β-catenin, non-small cells lung...
Context: Medullary thyroid carcinoma (MTC) is a cancer of the parafollicular C cells commonly caused by an inherited or acquired RET proto-oncogene mutation. Therapeutic resistance and recurrence disease imply presence stem in MTC. Objective: In this study, we sought to identify characterize cell-like Main Outcome Measures: The characterization cell properties was performed using immunostaining, flow cytometry, sphere formation assay, rederivation Western blotting, quantitative RT-PCR...
An increase in the morbidity of upper respiratory tract infections and attack exacerbation autoimmune diseases has been observed to occur few days following sudden environmental temperature decreases, but mechanisms for these phenomena are not well understood. To determine effect a ambient drop on levels stress hormones T‑lymphocyte cytokines plasma, Toll‑like receptor 4 (TLR4) expression immunocompetent cells rat spleens regulatory T (Treg) peripheral blood, Sprague Dawley rats were divided...
Background Gene therapy has tremendous potential for both inherited and acquired diseases. However, delivery problems limited their clinical application, new gene vehicles with low cytotoxicity high transfection efficiency are greatly required. Methods In this report, we designed synthesized three amphiphilic molecules (L1–L3) the structures involving 1, 4, 7, 10-tetraazacyclododecane (cyclen), imidazolium a hydrophobic dodecyl chain. Their interactions plasmid DNA were studied via...
Wnt inhibitory factor‑1 (WIF‑1) is an important antagonist of Wnt/β‑catenin signaling by binding to ligands. The downregulation WIF‑1 leads the development non‑small cell lung cancer (NSCLC). upregulation significantly inhibits proliferation and induces apoptosis inhibiting in NSCLC. However, mechanisms underlying inhibition WIF‑1‑mediated autophagy are poorly understood. Thus, this study, we aimed shed some light into these mechanisms. WIF‑1‑induced NSCLC cells was detected transmission...
Objectives Upper body fat has been associated with an unfavourable cardiometabolic risk. We aimed to investigate the associations between mid-upper arm circumference (MUAC), a novel indicator of upper fat, and wide spectrum risk profiles in Chinese population. Design setting Cross-sectional analyses were performed using data from well-defined community 2014, Shanghai, China. Participants A total 6287 adults (2310 men 3977 women) aged 40 years or older. Outcome measures Multivariable logistic...
Cisplatin is one of the most effective antitumor drugs for non-small cell lung carcinoma (NSCLC) patients. However, its efficacy has encountered a plateau due to side effects and drug resistance. Inducible nitric oxide (NO) synthase (iNOS) gene therapy been reported have in several types cancers enhances sensitivity cisplatin, but iNOS alone or combination with cisplatin cancer remain unclear. In current study, we evaluated cationic liposome (LP)-mediated transfection on enhancing low-dose...