A5005713769- Pharmacological Effects of Natural Compounds
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Advancements in Transdermal Drug Delivery
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Analysis
- Dermatology and Skin Diseases
- Acne and Rosacea Treatments and Effects
- Analytical Chemistry and Chromatography
- Virus-based gene therapy research
- Food Quality and Safety Studies
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Phytochemistry and Bioactivity Studies
- melanin and skin pigmentation
- Chromatography in Natural Products
- Advanced Chemical Sensor Technologies
- Medicinal Plant Pharmacodynamics Research
- Phytochemistry and biological activity of medicinal plants
- Higher Education and Teaching Methods
- Advanced Drug Delivery Systems
- Essential Oils and Antimicrobial Activity
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Traditional Chinese Medicine Studies
Southern Medical University
2016-2025
Key Laboratory of Guangdong Province
2022-2024
Bohai University
2024
State Ethnic Affairs Commission
2022-2024
Southwest Minzu University
2015-2024
South China University of Technology
2020-2024
Shanghai Ocean University
2024
Jilin Normal University
2007-2024
Harbin Institute of Technology
2022-2024
Syngenta (China)
2023
Background . Accumulative evidence showed that gut microbiota was important in regulating the development of nonalcoholic fatty liver disease (NAFLD). Hugan Qingzhi tablet (HQT), a lipid‐lowering and anti‐inflammatory medicinal formula, has been used to prevent treat NAFLD. However, its mechanism action is unknown. The aim this study confirm whether HQT reversed dysbiosis NAFLD rats. Methods We established an model rats fed with high‐fat diet (HFD), which given different interventions,...
Abstract Background The isopentenols, including isoprenol and prenol, are excellent alternative fuels. However, they not compounds largely accumulated in natural organism. need for the next generation of biofuels with better physical chemical properties impels us to develop biosynthetic routes production prenol from renewable sugar. In this study, we use heterogenous mevalonate-dependent (MVA) isoprenoid pathway synthesis isopentenyl pyrophosphate (IPP) dimethylallyl (DMAPP) intermediates,...
Sabinene, one kind of monoterpene, accumulated limitedly in natural organisms, is being explored as a potential component for the next generation aircraft fuels. And demand advanced fuels impels us to develop biosynthetic routes production sabinene from renewable sugar. In this study, was significantly produced by assembling pathway using methylerythritol 4-phosphate (MEP) or heterologous mevalonate (MVA) combining GPP and synthase genes an engineered Escherichia coli strain. Subsequently,...
Purpose: Lung cancer has a high incidence rate worldwide with 5-year survival of 18%, and is the leading cause cancer-related deaths. The aim this study to augment therapeutic efficacy quercetin (QR) for lung therapy by targeting transferrin receptors, which are overexpressed confined tumor cells. Methods: In study, T7 surface-functionalized liposomes loaded QR (T7-QR-lip) having different peptide densities (0.5%, 1% 2%) were prepared film hydration method. characterized evaluated in terms...
Artificial RNA translation modulation usually relies on multiple components, such as binding proteins (RBPs) or microRNAs (miRNAs) for off-switches and double-inverter cascades on-switches. Recently, translational circular RNAs (circRNAs) were developed promising alternatives linear messenger (mRNAs). However, circRNAs still lack straightforward programmable control strategies. Here, we rationally design a miRNA-responsive internal ribosome entry site (IRES) activation repression (PROMITAR)...
Oxidative stress and inflammation play important roles in the development of diabetes mellitus. p-Synephrine, primary pharmacologically active protoalkaloid Citrus species, has been popularly consumed as a dietary supplement for weight loss management. However, effects p-synephrine on mellitus action mechanisms have not clearly elucidated. In this study, vitro antioxidant were evaluated. The data showed that treatment exhibited significant scavenging against DPPH, ABTS OH radicals high...
Licorice flavonoid (LF) is the main component of Glycyrrhizae Radix et Rhizoma, a "medicine food homology" herbal medicine, which has anti-digestive ulcer activity, but mechanism in anti-gastric (GU) remains to be elucidated. In this study, we manifested that LF increased viability human gastric mucosal epithelial (GES-1) cells, attenuated ethanol (EtOH)-induced manifestations, reduced histological injury, suppressed inflammation, and restored barrier GU rats. After therapy, EtOH-induced gut...
This study was sought to investigate the chemical composition and antibacterial antiulcerative colitis (UC) effects of essential oil from Pruni Semen (PSEO). A GC-MS assay showed that major compounds in PSEO were products amygdalin hydrolysis, which possessed great anti-inflammatory potential. In vitro experiments demonstrated treatment inhibited activity four kinds intestinal pathogens probably by disrupting cell wall. Further vivo studies administration significantly improved physiological...
Isoliquiritigenin (ISL), a natural flavonoid isolated from the root of licorice (Glycyrrhiza uralensis), has shown various pharmacological properties including anti-oxidant, anti-inflammatory and anti-cancer activities. MicroRNAs (miRNAs), class small non-coding RNAs, have been reported as post-transcriptional regulators with altered expression levels in melanoma. This study aims to investigate anti-melanoma effect ISL its potential mechanism.We investigated on proliferation apoptosis...
This study aimed to systematically compare licochalcone A (LicA) and glabridin (Gla) (whitening agents) release permeation from Carbomer 940 (CP) hydrogels with different enhancers, evaluate the relationship between quantitative enhancement efficacy structures of enhancers. An in vitro an experiment solution using porcine skin were performed. We found that Gla-CP hydrogel showed a higher drug retention amount than LicA-CP due solubility medium better miscibility Gla LicA. Enhancers molecular...