A5066010568- Cancer-related molecular mechanisms research
- Pregnancy and preeclampsia studies
- Estrogen and related hormone effects
- Pluripotent Stem Cells Research
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Stress Responses and Cortisol
- MicroRNA in disease regulation
- Uterine Myomas and Treatments
- Gestational Diabetes Research and Management
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- Ovarian cancer diagnosis and treatment
- Maternal and fetal healthcare
- Circular RNAs in diseases
- Ectopic Pregnancy Diagnosis and Management
- Glycosylation and Glycoproteins Research
- Pregnancy-related medical research
- CRISPR and Genetic Engineering
- Renal and related cancers
- Endometriosis Research and Treatment
- Pelvic floor disorders treatments
- Cancer, Hypoxia, and Metabolism
- Prenatal Substance Exposure Effects
Tsinghua University
2023-2025
Shaanxi University of Chinese Medicine
2024
Qingdao University
2017-2023
Qingdao Municipal Hospital
2017-2023
Xishuangbanna Tropical Botanical Garden
2023
Second Military Medical University
2009-2022
Changhai Hospital
2009-2022
Central China Normal University
2022
Shandong Provincial Hospital
2016-2018
Shandong University
2016-2018
Recently, a large number of long non-coding RNAs (lncRNAs) have been reported in mammalian genomes and are evolutionarily conserved presumably function many biological events, especially the pathogenesis diverse human cancers. A lncRNA, named HOST2 (human ovarian cancer-specific transcript 2), was once to specifically be expressed at high level cancer. However, how acts regulate gene functions carcinogenesis has remained enigmatic. Here we report, for first time, that promotes tumor cell...
Abstract Human female germline stem cells (FGSCs) have opened new opportunities for understanding human oogenesis, delaying menopause, treating infertility and providing a strategy preserving fertility. However, the shortage of adult ovaries tissues available impedes their future investigations clinical applications. Here, we established FGSC lines from scarce ovarian cortical that exist in follicular aspirates (faFGSCs), which are produced discarded vitro fertilization centers worldwide....
Artificial RNA translation modulation usually relies on multiple components, such as binding proteins (RBPs) or microRNAs (miRNAs) for off-switches and double-inverter cascades on-switches. Recently, translational circular RNAs (circRNAs) were developed promising alternatives linear messenger (mRNAs). However, circRNAs still lack straightforward programmable control strategies. Here, we rationally design a miRNA-responsive internal ribosome entry site (IRES) activation repression (PROMITAR)...
MicroRNAs are noncoding RNA molecules of 18–25 nucleotides that regulate gene expression at the post-transcriptional levels. Recent data revealed miR-218 played key roles in tumor metastasis. Here, we described regulation and function cervical cancer. Overexpression reduced proliferation human cancer cell line HeLa induced apoptosis through AKT-mTOR signaling pathway. In addition, it forced suppressed growth orthotopic mouse model cells. Furthermore, increased chemosensitivity to cisplatin...
This paper proposes an approach based on the safeguarding of intangible cultural heritage (ICH) by studying value ICH to explore folk music mental health and its measures. Additionally, a questionnaire survey is conducted among college students. The Tibetan Guozhuang dance in are taken as object. students' awareness, participation, effects physical health, emotional regulation, stress regulation investigated, study music. results reveal that process participating art dance, 41.8% students...
Inhibition of calcium/calmodulin-dependent protein kinase II (CaMKII) results in hypophosphorylation CaMKII substrates and some cases suppresses cell growth. We previously presented the first report human inhibitory protein, hCaMKIINbeta. Here we functional characterization hCaMKIINbeta ovarian cancer cells. showed that was highly expressed normal tissues but not detected adenocarcinoma, indicating decreased expression may be involved pathogenesis adenocarcinoma. As an endogenous inhibitor,...
Dysregulated expression of microRNAs (miRNAs) has been observed in numerous types human cancer, including cervical cancer (CC). The present study aimed to elucidate the and roles miR‑181 tissues cells. HeLa cells with a stable overexpression were generated injected subcutaneously into front legs nude mice. Functional assays revealed reduced rate proliferation an enhanced apoptosis following transfection CC mimics. In addition, also suppressed tumor growth At molecular level, it was found...
Abstract The efficacy of the first-line treatment for hypopharyngeal carcinoma (HPC), a predominantly male cancer, at advanced stage is only about 50% without reliable molecular indicators its prognosis. In this study, HPC biopsy samples collected before and after are classified into different groups according to responses. We analyze changes tumor microenvironment (TME) single-cell level in response identify three gene modules associated with estimate cell constitutions based on bulk...
Abstract Context: Our previous study has demonstrated that CRH differential effects on human uterine contractility before and after onset of labor. Intracellular Ca2+ concentration ([Ca2+]i) mobilization plays an important role in the control contraction. Objective: objective was to investigate [Ca2+]i homeostasis laboring nonlaboring myometrial cells determine subsequent signaling involved regulation by CRH. Design: The tissues were obtained from pregnant women who undergoing or not labor...
Abstract Background Potassium channels play critical roles in the regulation of cell membrane potential, which is central to excitability myometrium. The ATP-sensitive potassium (KATP) channel one most abundant objectives this study were investigate protein expression KATP human myometrium and determine levels lower upper segmental before after onset labour. Methods Both (LS) (US) myometrial biopsies collected at cesarean section from pregnant women not-in-labour (TNL) or in-labour (TL)...
Cell adhesion to extracellular matrix (ECM) is controlled by multiple signaling molecules and intracellular pathways, pivotal for survival growth of cells from most solid tumors. Our previous works demonstrated that dexamethasone (DEX) significantly enhances cell resistance chemotherapeutics increasing the levels integrin β1, α4, α5 in human ovarian cancer cells. However, it unclear whether components ECM or other membrane are also involved pro-adhesive effect DEX In this study, we treatment...
Background Mesenchymal stem cells (MSC) have the capacity to differentiate into of connective tissue lineages, including bone, fat, cartilage and muscle, but differentiation embryonic MSC epidermal by mesenchymal‐epithelial transition has not been confirmed. Objectives To determine biological characteristics human (hMSC) their potential for epithelial cells. Methods hMSC were derived from 4–7‐week‐old embryos; they localized isolated, then primary culture was done. The detected...
Hydrogen sulfide (H2S) is a novel endogenous gaseous signaling transmitter in mammalian tissues including smooth muscle tissues. We investigated the effect of sodium hydrosulfide (NaHS), H2S donor, on contractility isolated human myometrium strips from term pregnant women who were undergoing labor. Cumulative effects NaHS spontaneous and oxytocin-induced evaluated by using isometric tension recordings. (0.1 μM–1 mM) concentration dependently inhibited laboring myometrium, with decrease...
Throughout gestation, the chorion laeve controls levels of biologically active prostaglandins (PGs) by its high level nicotinamide adenine dinucleotide-dependent 15-hydroxy PG dehydrogenase (PGDH). In this study, we investigate effects mediated CRH receptors on expression PGDH in chorion. We found that both CRHR1 and CRHR2 were localized cultured trophoblast cells, with CRH-R1alpha, R1beta, R1c, R1e, R1f CRHR2beta isoforms identified these cells. To block actions endogenous related peptides,...