A5062415019- Stress Responses and Cortisol
- Sulfur Compounds in Biology
- Birth, Development, and Health
- Hormonal Regulation and Hypertension
- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Estrogen and related hormone effects
- Neuroendocrine regulation and behavior
- Adrenal Hormones and Disorders
- Adenosine and Purinergic Signaling
- Neuroscience of respiration and sleep
- Reproductive System and Pregnancy
- Circular RNAs in diseases
- Pregnancy-related medical research
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Tryptophan and brain disorders
- Menopause: Health Impacts and Treatments
- Neuroscience and Neuropharmacology Research
- Cardiac Ischemia and Reperfusion
- Neonatal Respiratory Health Research
- Pregnancy and Medication Impact
- Nitric Oxide and Endothelin Effects
- Hydrogen's biological and therapeutic effects
- Peptidase Inhibition and Analysis
Mudanjiang Medical University
2017-2025
Jilin University
2024-2025
Central South University
2017-2024
Xiangya Hospital Central South University
2017-2024
Jiangsu University
2017-2024
Affiliated Hospital of Jiangsu University
2017-2024
Beijing Children’s Hospital
2019-2024
Capital Medical University
2019-2024
Huaqiao University
2019-2024
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry
2024
Abstract Background Autophagy plays a significant role in myocardial ischemia-reperfusion (IR) injury. So it is important to inhibit autophagy protect cardiomyocytes besides anti-apoptosis. MiRNA has been demonstrated against apoptosis during IR, while whether anti-autophagy effect not known. The aim of this study was investigate miR-204 regulated by regulating LC3-II protein, which the marker autophagosome IR Methods Adult SD rats were randomized Control and groups. group treated with 30...
Hydrogen sulfide (H2S), known as the third endogenous gaseous transmitter, has received increasing attention because of its diverse effects, including angiogenesis, vascular relaxation and myocardial protection.We aimed to investigate role H2S in oxidative/nitrative stress inflammation acute lung injury (ALI) induced by endotoxemia.Male ICR mice were divided six groups: (1) Control group; (2) GYY4137treatment (3) L-NAME treatment (4) lipopolysaccharide (LPS) (5) LPS with GYY4137 (6) group....
Preterm birth (PTB) is firmly linked to inflammation regardless of the presence infection. Proinflammatory cytokines, including IL-1β, are produced in gestational tissues and can locally upregulate uterine activation proteins. Premature uterus by may lead PTB, IL-1 has been identified as a key inducer this condition. However, all currently available inhibitors large molecules that exhibit competitive antagonism properties inhibiting IL-1R signaling, transcription factor NF-κB, which conveys...
The long non-coding RNA zinc finger E-box-binding homeobox 1 antisense (ZEB1-AS1) acts as an oncogenic regulator in many human tumours. In the present study, we identify role and potential molecular biological mechanisms of ZEB1-AS1 colon adenocarcinoma (COAD).QRT-PCR was used to detect expression ZEB1-AS1, miR-455-3p p21-activated kinases 2 (PAK2) COAD tissues. CCK8 assay, EdU transwell assay scratch wound were explore function cells. Bioinformatics, luciferase reporter assays pull-down...
Abstract Human female germline stem cells (FGSCs) have opened new opportunities for understanding human oogenesis, delaying menopause, treating infertility and providing a strategy preserving fertility. However, the shortage of adult ovaries tissues available impedes their future investigations clinical applications. Here, we established FGSC lines from scarce ovarian cortical that exist in follicular aspirates (faFGSCs), which are produced discarded vitro fertilization centers worldwide....
The aims of the present study were to investigate whether exercise can improve depression-like behavior caused by estrogen deficiency. Given that decreased level brain-derived neurotrophic factor (BDNF) in many brain areas including hippocampus and prefrontal cortex is associated with deficiency-induced behavior, we also determined affects levels BDNF its receptor (PFC). It was found ovariectomy (OVX) an increase rats a decrease but not PFC. expression TrkB, high affinity PFC affected OVX....
Rationale: Among all the diabetic complications, cardiomyopathy, which is characterized by myocyte loss and myocardial fibrosis, leading cause of mortality morbidity in patients. Tissue kallikrein-related peptidases (KLKs) are secreted serine proteases, that have distinct overlapping roles pathogenesis cardiovascular diseases. However, whether KLKs involved development cardiomyopathy remains unknown.The present study aimed to determine role a specific KLK initiation...
Abstract Regulation of Hybrid Materials Ministry Education, Bimetallic nanoclusters with synergistic effect exhibit better stability and activity than monometallic in catalytic applications. However, the large number ligands on surface obscure active sites, thus reducing activity. Here, AuCu 24 /AC−X (X=0, 200, 300, 500, 800) catalysts were fabricated by removing partial H 22 ((p‐FPh) 3 P) 12 (short for NCs), investigated influence calcination temperature performance /AC homocoupling...
Abstract Wound healing is a common occurrence. However, delayed and aberrant scarring result in pathological wound healing. Accordingly, scarless remains significant clinical challenge. In this study, we constructed hyaluronic acid (HA)-modified verteporfin (VP)-loaded polylactic (PLA) nanogels (HA/VP-PLA) to promote by accelerating re-epithelialization controlling scar formation. Owing the unique structure of HA incorporating coating VP-loaded PLA nanoparticles, HA/VP-PLA could be topically...
Hydrogen sulfide (H2S) has been implicated to have antidepressive effects. We sought investigate the prevention effects of H2S donor NaHS on depression-like behavior induced by lipopolysaccharide (LPS) in mice and its potential mechanisms. Sucrose preference, force swimming, open field, elevate zero maze were used evaluate behavior. NF-κB NLRP3 inflammasome activation mitochondrial function hippocampus determined. It was found that LPS prevented pretreatment. caused as evidenced increased...
Biphenotypic acute leukemia is a rare disorder that difficult to diagnose. It displays features of both myeloid and lymphoid lineage. There still lack studies in biphenotypic Chinese population. We present here comprehensive investigation the clinical biological characteristics, outcome our hospital over seven year period.We retrospectively analyzed 452 adult patients diagnosed according French-American-British (FAB) classification European Group for Immunological Characterization Leukemias...
Background: Autophagy plays a significant role in myocardial ischemia reperfusion (IR) injury. Hydrogen sulfide (H2S) has been demonstrated to protect cardiomyocytes against IR injury, while whether it anti-autophagy effect not known. The aim of this study was investigate H2S regulates autophagy during injury and its possible mechanism. Methods Results: neonatal rats were randomized into Con, hypoxia-reoxygenation (HR) protection groups. severity cell evaluated by vitality (MTT) lactate...
Hydrogen sulfide (H2S), generated in the myocardium predominantly via cystathionine-γ-lyase (CSE), is cardioprotective. The objectives of present study were to investigate effects estrogens on CSE expression and H2S generation examine whether serum 17β-estradiol (E2) level associated with activity or E2 proinflammatory cytokines oxidative stress status.Ovariectomized Sprague-Dawley rats received subcutaneous (30 μg/kg/d) vehicle for 12 weeks. At end 12-week treatment, expression, generation,...
// Wenkang Luan 1, * , Rubo Li 2, Liang Liu 3, Xin Ni 4, Yan Shi 3 Yun Xia 1 Jinlong Wang Feng Lu and Bin Xu Department of Plastic Surgery, Affiliated People's Hospital Jiangsu University, Zhenjiang, China 2 Neurosurgery, Nanjing First Hospital, Medical Nanjing, 4 Gastroenterology, These authors have contributed equally to this work Correspondence to: Luan, email: luanwenkang@126.com Xu, xubinfen@126.com Keywords: malignant melanoma, ceRNA, HOTAIR, miR-152-3p, c-MET Received: April 15,...
Abstract Hydrogen sulfide, generated in the myocardium predominantly via cystathionine-γ-lyase (CSE), is cardioprotective. Our previous study has shown that estrogens enhance CSE expression of female rats. The present aims to explore mechanisms by which regulate expression, particular clarify role estrogen receptor subtypes and transcriptional factor responsible for estrogenic effects. We found either inhibitor or small interfering RNA attenuated protective effect 17β-estradiol (E2) against...