A5024592036- interferon and immune responses
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cytokine Signaling Pathways and Interactions
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- RNA modifications and cancer
- Obstructive Sleep Apnea Research
- Immune Cell Function and Interaction
- Neuroscience of respiration and sleep
- Immune Response and Inflammation
- Ubiquitin and proteasome pathways
- NF-κB Signaling Pathways
- Head and Neck Cancer Studies
- Liver Disease Diagnosis and Treatment
- Voice and Speech Disorders
- Immune cells in cancer
- Respiratory and Cough-Related Research
- Calcium Carbonate Crystallization and Inhibition
- High Altitude and Hypoxia
- Sleep and Wakefulness Research
- Liver physiology and pathology
- Tracheal and airway disorders
- Hepatitis B Virus Studies
- RNA Research and Splicing
Second Military Medical University
2013-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2014-2024
South China University of Technology
2021-2022
Institute of Immunology
2010-2022
Xi'an Jiaotong University
2013-2016
Southeast University
2016
Changhai Hospital
2009-2013
Chinese Academy of Medical Sciences & Peking Union Medical College
2013
Fudan University Shanghai Cancer Center
2013
Tsinghua University
2006-2011
Noncoding RNAs play important roles in cancer biology, providing potential targets for intervention. As a new class of endogenous noncoding RNAs, circular (circRNAs) have been recently identified cell development and function, certain types pathological responses, generally acting as microRNA (miRNA) sponge to regulate gene expression. Identifying the deregulated circRNAs their has attracted much attention. However, expression profile function human hepatocellular carcinoma (HCC) remain be...
Abstract Upon recognition of viral components by pattern receptors, including TLRs and retinoic acid-inducible gene I (RIG-I)- like helicases, cells are activated to produce type IFN proinflammatory cytokines. These pathways tightly regulated host prevent inappropriate cellular response, but viruses can down-regulate these for their survival. Recently, identification negative regulators cytoplasmic RNA-mediated antiviral signaling, especially the RIG-I pathway, attract much attention....
Abstract Effective recognition of viral infection and subsequent triggering antiviral innate immune responses are essential for the host defense, which is tightly regulated by multiple regulators, including microRNAs. Our previous study showed that a panel microRNAs, miR-155, was markedly upregulated in macrophages upon vesicular stomatitis virus infection; however, biological function miR-155 during remains unknown. In this paper, we show RNA induces expression via TLR/MyD88-independent but...
In our in-depth analysis carried out by the Illumina Solexa massive parallel signature sequencing, microRNA-99a (miR-99a) was found to be sixth abundant microRNA in miRNome of normal human liver but markedly down-regulated hepatocellular carcinoma (HCC). Compelling evidence has suggested important roles microRNAs HCC development. However, biological function miR-99a deregulation remains unknown. this study, we that remarkably decreased tissues and cell lines. Importantly, lower expression...
NK cells are important innate immune with potent cytotoxicity that can be activated by type I IFN from the host once infected. How cell is and then tightly regulated remain to fully elucidated. MicroRNAs (miRNAs, or miRs) regulators of response, but full scale miRNome in human remains determined. In this study, we reported an in-depth analysis miRNomes resting IFN-α-activated cells, found two abundant miRNAs, miR-378 miR-30e, markedly decreased IFN-α, further proved miR-30e directly targeted...
Although B cells play important roles in the humoral immune response and regulation of adaptive immunity, cell subpopulations with unique phenotypes, particularly those non-classical functions, should be further investigated. By challenging mice Listeria monocytogenes, Escherichia coli, vesicular stomatitis virus Toll-like receptor ligands, we identified an inducible CD11ahiFcγRIIIhi subpopulation that is significantly expanded produces high levels IFN-γ during early stage response. This can...
Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine and exerts its complex biological functions mainly through three different signal modes, called cis- , trans- cluster signaling. When IL-6 binds to membrane or soluble receptors, the co-receptor gp130 activated initiate downstream signaling induce expression of target genes. In liver, can perform anti-inflammatory activities promote hepatocyte reprogramming liver regeneration. On contrary, also pro-inflammatory aging, fibrosis,...
Deregulated micro RNA s and their roles in carcinogenesis cancer progression have attracted much attention. In previous studies conducted our laboratory, the Illumina Solexa massively parallel signature sequencing of mi RN omes nontumor hepatocellular carcinoma ( HCC ) tissues revealed that miR‐486‐5p was significantly downregulated , but its role development remains unknown. this study, levels matched control tissues, seven cell lines QGY ‐7701, ‐7703, ‐7404, SMMC ‐7721, Huh7, HepG2, PCL /...
microRNA (miRNA) dysregulation is involved in the development and progression of various human cancers, including hepatocellular carcinoma (HCC). However, how to identify miRNAs targeting specific mRNA cells a significant challenge because interaction complexity limited knowledge rules governing these processes. Some are not predictable by current computer algorithms available. Here, using p21 as target, we established new method, called miRNA vivo precipitation (miRIP), which kind can...
Adjuvant interferon-α (IFN-α) therapy is used to control certain types of cancer in clinics. For hepatocellular carcinoma (HCC), IFN-α effective only a subgroup patients; therefore, identifying biomarkers predict the response high significance and clinical utility. As induced IFN-stimulated gene expression following treatment plays pivotal roles effects, we screened HCC tissues found that several genes were significantly decreased HCC. Interestingly, IFN-induced protein with...
Hepatocarcinogenesis is driven by necroinflammation or metabolic disorders, and the underlying mechanisms remain largely elusive. We previously found that retinoic acid-inducible gene-I (RIG-I), a sensor for recognizing RNA virus in innate immune cells, mainly expressed parenchymal hepatocytes liver. However, its roles hepatocarcinogenesis are unknown, which intensively investigated this study.DEN-induced necroinflammation-driven STAM NASH-hepatocarcinogenesis were carried out...
Biphenotypic acute leukemia is a rare disorder that difficult to diagnose. It displays features of both myeloid and lymphoid lineage. There still lack studies in biphenotypic Chinese population. We present here comprehensive investigation the clinical biological characteristics, outcome our hospital over seven year period.We retrospectively analyzed 452 adult patients diagnosed according French-American-British (FAB) classification European Group for Immunological Characterization Leukemias...
Abstract Dendritic cells (DCs) play critical roles in cross-priming to induce the CTL response against infection; however, molecular mechanisms for regulation of DC need be investigated further, which may help improve potency vaccines through engineering modifications. Our previous studies showed that β2 integrin CD11b could control TLR-triggered NK cell cytotoxicity and macrophage inflammatory responses. is also abundantly expressed DCs, but it unknown whether participates response. Also,...
Innate immune responses must be tightly regulated to avoid overactivation and subsequent inflammatory damage host tissue while eliminating invading pathogens. IL-10 is a crucial suppressor of its expression under precise regulation involving complex regulatory networks multiple feedback loops. MicroRNAs are now emerging as critical regulators in response. Our previous work showed that miR-143/145 cluster was markedly downregulated macrophages upon vesicular stomatitis virus infection....