A5100322407- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Mycobacterium research and diagnosis
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer therapeutics and mechanisms
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Molecular Biology Techniques and Applications
- Cancer-related Molecular Pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bladder and Urothelial Cancer Treatments
- Extracellular vesicles in disease
- Cancer Research and Treatments
- Pharmacogenetics and Drug Metabolism
- Cerebrospinal fluid and hydrocephalus
- Lipid metabolism and disorders
- Nanoplatforms for cancer theranostics
- Teratomas and Epidermoid Cysts
Nanjing Medical University
2017-2025
Nanjing Brain Hospital
2023-2025
Southwest Medical University
2024
Hebei Medical University
2021-2024
Second Hospital of Hebei Medical University
2024
Zhongshan Hospital
2009-2023
Fudan University
2009-2023
Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality
2023
Southern Medical University
2020-2023
Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine
2020-2023
Bone is a frequent metastatic site of non-small cell lung cancer (NSCLC), and bone metastasis (BoM) presents significant challenges for patient survival quality life. Osteolytic BoM characterised by aberrant differentiation malfunction osteoclasts through modulation the TGF-β/pTHrP/RANKL signalling pathway, but its upstream regulatory mechanism unclear. In this study, we found that lncRNA-SOX2OT was highly accumulated in exosomes derived from peripheral blood NSCLC patients with higher...
Abstract Long non-coding RNAs (lncRNAs) play a vital role in tumourigenesis, including that of glioma. Small nucleolar RNA host gene 1 (SNHG1) is relatively novel lncRNA involved the development multiple human tumours. However, its underlying molecular mechanism glioma has not been completely clarified. In this study, we show SNHG1 overexpressed tissues and cell lines. A series functional assays suggested promotes progression vitro vivo. Next, through online databases, luciferase reporter...
// Wenkang Luan 1, * , Rubo Li 2, Liang Liu 3, Xin Ni 4, Yan Shi 3 Yun Xia 1 Jinlong Wang Feng Lu and Bin Xu Department of Plastic Surgery, Affiliated People's Hospital Jiangsu University, Zhenjiang, China 2 Neurosurgery, Nanjing First Hospital, Medical Nanjing, 4 Gastroenterology, These authors have contributed equally to this work Correspondence to: Luan, email: luanwenkang@126.com Xu, xubinfen@126.com Keywords: malignant melanoma, ceRNA, HOTAIR, miR-152-3p, c-MET Received: April 15,...
We present the case of an adolescent female patient diagnosed with a ruptured lateral ventricle teratoma. Distinctive radiological and microscopic findings revealed floating oily globules within ventricles subarachnoid space. The spontaneous rupture teratoma may be attributed to age-dependent hormonal changes, which increase glandular secretion, cyst content volume, intra-cystic pressure. underwent gross total resection tumor, subsequent pathological examination confirmed diagnosis mature...
Lung cancer is the leading cause of cancer-associated mortalities worldwide. Non-small-cell lung (NSCLC) main reason for cancer-relevant death and constitutes 80% cases. Long noncoding RNAs (lncRNAs) have been found to be related different kinds cancer. played important roles in regulating pathological physiological processes numerous cancers. To explore novel adenocarcinoma-associated lncRNAs, we analyzed TCGA database that lncRNA SNHG3 was significantly upregulated adenocarcinoma....
Nonsmall cell lung cancer (NSCLC) is a type of malignant tumor, accounting for 80% all morbidity. Long noncoding RNA (lncRNA) BLACAT1 (bladder associated transcript 1), also known as linc-UBC1, has been tested to be an oncogenic lncRNA in other cancers. However, the role NSCLC still unknown. In clinical study, expression was significantly upregulated 48 cases tissues compared with adjacent normal tissues, especially pathological TNM III samples. cells, upregulated. Both vivo and vitro,...
Numerous studies have reported that long noncoding RNA (lncRNA) dysregulation is involved in the progression of many malignant tumors, including glioma. The lncRNA ZNFX1 antisense 1 (ZFAS1) plays an oncogenic role various such as gastric cancer and hepatocellular carcinoma. However, underlying molecular mechanism ZFAS1 glioma has not been fully clarified. In this study, we found expression was upregulated both tissues cell lines. Functional experiments revealed promoted proliferation,...
Hepatic artery ligation (HAL), transarterial embolization (TAE), and chemoembolization (TACE) have been treatment choices for unresectable hepatocellular carcinoma (HCC). Obstruction of tumor blood supply is one the most important mechanisms these therapeutics measures. Here we introduced HAL into a metastatic human HCC orthotopic nude mouse model (using MHCC97L HepG2 cell lines) to examine effects hepatic flow obstruction on potential cells, investigate underlying effects. Our results...
Previous studies suggested long noncoding RNA metastasis associated with lung adenocarcinoma transcript 1 (lncRNA MALAT1) acted as a tumor promoter to promote cell carcinogenesis in non-small cancer (NSCLC). MALAT1 was found exist serum exosomes of several cancers. However, the role exosomal-derived NSCLC remains poorly understood.Exosomes were isolated using ExoQuick precipitation kit. Western blot used detect protein expression CD3, CD63, apoptosis- and metastasis-related protein. The...
Lung cancer is devastating that ranks as the leading cause of cancer-related death. Long noncoding RNA (lncRNA) opioid growth factor receptor pseudogene 1 (OGFRP1) was recognized an oncogene in many cancers. However, molecular mechanism OGFRP1 lung still poorly understood. The expression target RNAs and genes detected by quantitative real-time PCR western blot. interaction between miR-299-3p or solute carrier family 38 member (SLC38A1) predicted StarbaseV3.0 verified dual-luciferase reporter...
Abstract Background This study aimed to explore the correlation of long non‐coding RNA metastasis‐associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) with microRNA (miR)‐125b and further investigated their associations disease risk, severity, prognosis coronary heart (CHD). Methods Totally, 230 patients who underwent diagnostic angiography were recruited; meanwhile, 140 them diagnosed as CHD remaining 90 non‐CHD served controls. Plasma sample was collected from each participant for...
UDP-glucuronosyltransferases (UGTs), the most important enzymes in body detoxification and homeostasis maintaining, govern glucuronidation reaction of various endogenous environmental carcinogens. The metabolic function UGTs can be severely influenced by hepatocellular carcinoma (HCC), fifth prevalent third malignant cancer worldwide. Particularly China, HBV-positive HCC account for approximately 80% patients. But rare papers addressed alteration on metabolism specific substrates,...
CRISPR-CasRx technology provides a new and powerful method for studying cellular RNA in human cancer. Herein, the pattern of expression long noncoding 00341 (LINC00341) as well its biological function bladder cancer were studied using CRISPR-CasRx. qRT-PCR was employed to quantify levels LINC00341 tumor tissues along with matched non-tumor tissues. sgRNA targeting or negative control transiently transfected into T24 5,637 cell lines. CCK-8, ELISA wound healing methods explore proliferation,...
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung condition with unknown etiology and high mortality. Chinese herbal medicine has been used for more than thousand years to treat various diseases.The current study aimed examine whether Maxing Huoqiao Decoction (MXHQD) exerts therapeutic effects on IPF further uncover its underlying molecular mechanisms.Mouse model of acute injury (ALI) or was induced by intratracheal instillation LPS bleomycin,...
Abstract Glioma is the most common malignant tumor in central nervous system, and its unique pathogenesis often leads to poor treatment outcomes prognosis. In 2021, World Health Organization (WHO) divided gliomas into five categories based on their histological characteristics molecular changes. Non-coding RNA a type of that does not encode proteins but can exert biological functions at level, long non-coding (lncRNA) with length exceeding 200 nt. It controlled by various transcription...
Abstract Glioblastoma (GBM) recurrence is attributed to the presence of therapy‐resistant glioblastoma stem cells. Steroid receptor coactivator‐1 (SRC‐1) acts as an oncogenic regulator in many human tumors. The relationship between SRC‐1 and GBM has not yet been studied. Herein, we investigate role GBM. In this study, found that expression positively correlated with grades glioma inversely patient’s prognosis. promotes proliferation, migration, tumor growth Notably, knockdown suppresses...
Purpose: LINC00680 was reported to be involved in various cancers through multiple mechanisms. Therefore, we intended investigate its role the progression of non-small cell lung cancer (NSCLC). Materials and Methods: Firstly, quantitative real-time polymerase chain reaction (qRT-PCR) used test NSCLC tissue lines. Subsequently, A549 H1299 cells were transfected with overexpressing plasmids their proliferation colony formation apoptosis tested by Transwell assay flow cytometry. In addition,...
Recent studies have reported that cancer associated fibroblasts (CAFs) and glioma stem-like cells (GSCs) played active roles in progression tumor microenvironment (TME). Long non-coding RNAs (lncRNAs) been found to be closely with development recent years, however, their molecular regulatory mechanisms on CAFs GSCs remodeled TME kept largely unelucidated. Our study could induce malignant transformation of (t-FBs) based dual-color fluorescence tracing orthotopic model. Associated poor...
Abstract In recent years, many studies have reported on the abnormal expression and correlation of long non-coding RNAs (lncRNAs) in tumours. However, accurate molecular mechanism lncRNAs glioma is still its infancy. present study, we aimed to explore small nucleolar RNA host gene 5 (SNHG5) progression. First, found that SNHG5 was higher related glucose uptake, migration invasion. Second, through a series assays, concluded acts as sponge for miR-205, which inhibits tumour growth by targeting...
Insulin-like growth factor binding protein 4-1 (IGFBP4-1), a new long noncoding RNA (lncRNA), has been reported to contribute tumorigenesis and suggested be poor prognostic marker in human lung cancer. However, there still lacks basic studies that investigated the biological role of IGFBP4-1 bladder urothelial carcinoma date. In this study, we relationship between expression prognosis patients with Cell proliferation, cell cycle apoptosis assays were performed assess function by...