A5080192797- Cancer Cells and Metastasis
- Pulmonary Hypertension Research and Treatments
- ATP Synthase and ATPases Research
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Eicosanoids and Hypertension Pharmacology
- Nanoparticle-Based Drug Delivery
- HER2/EGFR in Cancer Research
- Advancements in Battery Materials
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Protein Tyrosine Phosphatases
- MXene and MAX Phase Materials
- Extracellular vesicles in disease
- HIV-related health complications and treatments
- Sphingolipid Metabolism and Signaling
- Thermal properties of materials
- Glutathione Transferases and Polymorphisms
- Estrogen and related hormone effects
- Effects and risks of endocrine disrupting chemicals
- Conducting polymers and applications
- Endoplasmic Reticulum Stress and Disease
- Cancer, Lipids, and Metabolism
- Advanced Sensor and Energy Harvesting Materials
- Cancer Genomics and Diagnostics
Institute of Biosciences and Bioresources
2025
Shaanxi University of Science and Technology
2025
Dalian Medical University
2018-2024
Second Affiliated Hospital of Dalian Medical University
2018-2024
Shanghai Jiao Tong University
2023-2024
Air Force Medical University
2023
Yan'an University
2022-2023
Jiangxi University of Science and Technology
2023
Shenyang Pharmaceutical University
2018-2019
Layered oxides with high nickel content are advanced cathode materials for high-energy-density lithium-ion batteries but still suffer from severe voltage decay and cycling instability. Herein, a nano-Li2SnO3 coating Sn4+-doping co-stabilized Co-free LiNi0.8Mn0.2O2 (NM-82) cathodes were synthesized through the adsorption of tin dioxide sol, followed by high-temperature calcination. Profiting co-benefits, electrochemical reversibility rate capability NM-82 electrode have been significantly...
Resistance to epidermal growth factor receptor (EGFR) inhibitors, from the first-generation erlotinib third generation osimertinib, is a clinical challenge in treatment of patients with EGFR-mutant lung adenocarcinoma. Our previous work found that novel allosteric inhibitor phosphoglycerate mutase 1 (PGAM1), HKB99, restrains resistance adenocarcinoma cells. However, role HKB99 osimertinib and its underlying molecular mechanism remains be elucidated. Herein, we IL-6/JAK2/STAT3 signaling...
Objective— Hypoxic pulmonary hypertension (HPH) is characterized by proliferative vascular remodeling. Abnormal artery smooth muscle cells proliferation and endothelial dysfunction are the primary cellular bases of AQP1 (aquaporin-1) regulated oxygen level has been observed to play a role in migration cells. The HPH pathogenesis not directly determined date. To determine possible roles explore its mechanisms. Approach Results— Aqp1 knockout mice were used, model was established this study....
Background Background: Bisphenol A (BPA) is an estrogen‐like chemical widely contained in daily supplies. There evidence that environmental exposure to BPA could contribute the development of hormone‐related cancers. As reported numerous studies, melatonin, endogenous hormone secreted by pineal gland, markedly inhibit estrogen‐induced proliferation breast cancer (BC) cells. In this study, we intended reveal effects melatonin on BPA‐induced estrogen receptor‐positive BC Methods Methods: We...
Abstract Glioblastoma (GBM) recurrence is attributed to the presence of therapy‐resistant glioblastoma stem cells. Steroid receptor coactivator‐1 (SRC‐1) acts as an oncogenic regulator in many human tumors. The relationship between SRC‐1 and GBM has not yet been studied. Herein, we investigate role GBM. In this study, found that expression positively correlated with grades glioma inversely patient’s prognosis. promotes proliferation, migration, tumor growth Notably, knockdown suppresses...
Dasatinib treatment is approved as first-line therapy for chronic myeloid leukemia. However, pulmonary hypertension (PH) a highly morbid and often fatal side-effect of dasatinib, characterized by progressive vascular remodeling. Melatonin exerts strong antioxidant capacity against the progression cardiovascular system diseases. The present work aimed to investigate effect melatonin on dasatinib-aggravated hypoxic PH explore its possible mechanisms. Dasatinib-aggravated rat experimental model...
Colorectal cancer (CRC) is a prevalent malignant tumor often leading to liver metastasis and mortality. Despite some success with PD-1/PD-L1 immunotherapy, the response rate for colon patients remains relatively low. This closely related immunosuppressive microenvironment mediated by tumor-associated macrophages (TAMs). Our previous work identified that phosphoglycerate mutase 1 (PGAM1) allosteric inhibitor, HKB99, exerts range of anti-tumor activities in lung cancer. Here, we found upregulation
In this study, a synthetic high-density lipoprotein (sHDL), peptide-based nanocarrier loaded with docetaxel (DTX) was constructed, against breast cancer. The thermodynamic and molecular dynamic analyses were conducted to examine the stability of nanoparticles synthesized from mimetic peptide 5 A various types phospholipids. Furthermore, cellular uptake in vivo fluorescence imaging analysis experiments, scavenger receptor B-I (SR-BI) carried out tumor-targeting ability sHDL. investigated for...
Abstract Background Patients with pancreatic ductal adenocarcinoma (PDAC) who undergo surgical resection and receive effective chemotherapy have the best chance for long‐term survival. Unfortunately, because of heterogeneity cancer, it is difficult to find a personalized treatment strategy patients. Organoids are ideal preclinical models medicine. Therefore, we explore cultivation conditions construction methods PDAC organoid screen individualized therapy strategy. Methods Fresh tissues from...
Background/Aims: HER2 has been implicated in mammary tumorigenesis as well aggressive tumor growth and metastasis. Its overexpression is related to a poor prognosis chemoresistance breast cancer patients. Although Grb2-associated binding protein 2 (Gab2) important the development progression of human cancer, its effects mechanisms HER2-overexpressing are unclear. Methods: Clone formation MTT assays were used examine cell proliferation. To detect effect Gab2 on stemness cells, we flow...
We report a simple strategy to prepare Tween 60@2β-CD self-assembly vesicles in aqueous solution as new drug delivery carrier for cancer chemotherapy. The spherical shape of was confirmed by transmission electron microscopy (TEM) and mean particle sizes were about 33.7 nm, measured dynamic light scattering, micro-IR results indicated that the driven hydrogen bonding. Hydrophilic doxorubicin (DOX) successfully loaded into with loading content 7.85% efficiency 42%. In addition, an vitro...
Gallbladder cancer is a highly aggressive malignancy with poor sensitivity to postoperative radiotherapy or chemotherapy; therefore, the development of individualized treatment strategies paramount improve patient outcomes. Both patient-derived tumor xenograft (PDX) and organoid (PDO) models derived from surgical specimens can better preserve biological characteristics heterogeneity individual original tumors, display unique advantage for therapy predicting clinical In this study, PDX PDO...
Abstract RAS is the most frequently mutated oncoprotein for cancer driving. Understanding of biology and discovery druggable lynchpins in pathway a prerequisite targeted therapy RAS-mutant cancers. The recent identification KRAS G12C inhibitor breaks “undruggable” curse on has changed paradigm KRAS-mutant However, mutations, let alone mutation, account only part RAS-mutated Targeted therapies cancers harboring other mutations remain urgent need. In this study we explored pivotal regulatory...