A5031240237- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Liver Disease and Transplantation
- Alcohol Consumption and Health Effects
- Boron and Carbon Nanomaterials Research
- Sphingolipid Metabolism and Signaling
- Diet, Metabolism, and Disease
- RNA Research and Splicing
- Aluminum Alloys Composites Properties
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Graphene research and applications
- Cancer-related molecular mechanisms research
- Carbon Nanotubes in Composites
- Metabolism and Genetic Disorders
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
- Cardiac Ischemia and Reperfusion
- Circular RNAs in diseases
- Innovative concrete reinforcement materials
- Computational Drug Discovery Methods
- Heat shock proteins research
- Geotechnical Engineering and Soil Stabilization
- Ubiquitin and proteasome pathways
Xi'an University of Architecture and Technology
2015-2024
Dalian Medical University
2012-2024
Second Affiliated Hospital of Dalian Medical University
2012-2024
Capital University of Physical Education and Sports
2024
Henan Provincial Institute of Communications Planning Survey & Design (China)
2021
Medical University of South Carolina
2010-2018
Heidelberg University
2012
Background/Aims An increase of ethanol metabolism and hepatic mitochondrial respiration occurs in vivo after a single binge alcohol. Here, our aim was to determine how intake affects polarization status relation steatosis. Methods Hepatic polarization, permeability transition (MPT), reduce pyridine nucleotides, steatosis mice were monitored by intravital confocal/multiphoton microscopy the fluorescence rhodamine 123 (Rh123), calcein, NAD(P)H, BODIPY493/503, respectively, gavage with (1–6...
Background. Massive hepatectomy (MHX) leads to failure of remnant livers. Excessive metabolic burden in livers may cause mitochondrial dysfunction. This study investigated whether blockade the permeability transition (MPT) with N-methyl-4-isoleucine cyclosporine (NIM811) improves outcome MHX. Methods. Mice were gavaged NIM811 (10 mg/kg before surgery and 5 daily afterward) underwent sham-operation or approximately 90% partial hepatectomy. Results. Serum alanine aminotransferase, necrosis,...
Growing teratoma syndrome (GTS) is a rare clinical entity first described by Logothetis et al in 1982. Although it unusual for GTS to be located the ovary, this report of case an adolescent girl who underwent complete surgical resection mass. Histopathology confirmed only immature had originated from ovary and so she received adjuvant chemotherapy with blemycin, etopside, cisplatin over 4 cycles. Results abdominal enhanced CT (computed tomography) 9 years later revealed giant mass compressed...
// Chengyong Dong 1, * , Baofeng Zhao 2, 6, 7, Fei Long 1 Ying Liu 3, 4 Zhenzhen Song Li Xuejun Yang Deguang Sun Haibo Wang Qinlong Rui Liang Yan Zhenming Gao Shujuan Shao 5 Qing Robert Miao 8 Liming Division of Hepatobiliary and Pancreatic Surgery, Department General The Second Affiiated Hospital Dalian Medical University, Dalian, Liaoning, China 2 Key Laboratory Separation Science for Analytical Chemistry, National Chromatographic R & A Center, Institute Chemical Physics, Chinese Academy...
Inflammation mediates/promotes graft injury after liver transplantation (LT). This study investigated the roles of sphingosine kinase-2 (SK2) in inflammation LT. Liver grafts were stored UW solution with and without ABC294640 (100 µM), a selective inhibitor SK2, before implantation. Hepatic sphingosine-1-phosphate (S1P) levels increased ∼4-fold LT, which was blunted by 40% ABC294640. toll-like receptor-4 (TLR4) expression nuclear factor-κB (NF-κB) p65 subunit phosphorylation elevated...
Globally, hepatocellular carcinoma (HCC) is the sixth most common malignancy and it has fourth highest mortality. MicroRNAs play a significant part in biological processes cell formation advancement by targeting genes many cancers including HCC. In present study we examine involvement of miR-4521 FAM129A correlations HCC occurrence progression. Expression levels tissues cells were detected. Immunohistochemistry was carried out to detect expression FAM129A, MMP9 TIMP-1 tissues. Western blot...
Vascular remodeling due to hypertension is one of the major health challenges facing countries around world. Neohesperidin, a flavonoid glycoside found in citrus fruits, an antioxidant. Neohesperidin has been studied for variety diseases addition hypertension. In this study, angiotensin II was used induce mice (490 ng/kg/min, 14 days). We H&E, Masson, immunofluorescence, dihydroethidine and qPCR evaluate effect Nehesperidin (50 mg/kg/day, 16 days) on pathological mice. Estimating human...
In the realm of obesity and overweight, risk chronic diseases significantly escalates, closely intertwined with inflammatory factors. Research suggests that specific exercise interventions, particularly aerobic resistance exercise, can have beneficial effects on inflammation levels. However, debates persist regarding actual impact in obese overweight population. We employed meta-analysis research methods searched China National Knowledge Infrastructure Wanfang Data, PubMed, Web Science...
Actin filament-associated protein 1 antisense RNA (AFAP1-AS1), a long non-coding transcribed from the strand of coding gene AFAP1, has attracted attention in cancer research. Despite, its biological function and regulatory mechanism hepatocellular carcinoma still unknown. The present study revealed AFAP1-AS1 mediated hepatocarcinoma progression through targeting CRKL. bidirectional interaction oncogenic CRKL, deregulation effects on Ras, MEK c-Jun activities were investigated depth. was...
As a member of annexin family proteins, A3 (ANXA3) has 36-kDa and 33-kDa isoforms. ANXA3 plays crucial roles in the tumorigenesis, aggressiveness drug-resistance cancers. However, previous studies mainly focused on role total cancers without distinguishing distinction between two isoforms, cancer remains unclear. Current work aimed to investigate function regulation mechanism hepatocarcinoma. The expressions ANXA3, CRKL, Rac1, c-Myc pAkt were analyzed hepatocarcinoma specimens by Western...
Mixed acinar-endocrine carcinoma (MAEC) of the pancreas is a rare entity. We present 65-year-old Chinese female who was admitted with jaundice and nagging epigastric pain intermittent diarrhea for 1 month. She eventually underwent abdominal magnetic resonance imaging, which showed an 8×6 cm mass in head two abnormal lesions liver simultaneously. MAEC synchronous hepatic metastasis confirmed immunohistochemistry after Whipple operation partial resection lesions. Postoperative recovery this...
Tumor metastasis is one of the main causes high mortality hepatocellular carcinoma (HCC). E-Twenty Six variant gene 6 (ETV6) a strong transcriptional repressor, associated with development and progression tumors. However, exact role underlying mechanism ETV6 in HCC remain unclear.Western blotting, quantitative real-time PCR immunohistochemistry were used to detect expression levels ETV6, CRKL (v-crk sarcoma virus CT10 oncogene homologue (avian)-like) miR-429 tissues cells; Transwell chamber...
Background Ischemia/reperfusion injury (IRI) is commonly considered to play a crucial role in the pathogenesis of small-for-size syndrome (SFSS) after liver transplantation. Rapid regeneration also essential for survival SFS grafts. Methods Mouse models full-size orthotopic transplantation, 50% partial transplantation and 30% were established. Survival rate serum alanine aminotransferase observed. IRI was assessed by hepatic pathologic alterations, apoptosis necrosis. Regeneration response...
Aristolochic acid (AA), extracted from Aristolochiaceae plants, plays an essential role in traditional herbal medicines and is used for different diseases. However, AA has been found to be nephrotoxic known cause aristolochic nephropathy (AAN). AA-induced acute kidney injury (AKI) a syndrome AAN with high morbidity that manifests mitochondrial damage as key part of its pathological progression. Melatonin primarily serves mitochondria-targeted antioxidant. protective AKI barely reported. In...
In this paper, the mechanical properties, including elastic deformation mechanism, dislocation formation and crack propagation of graphene/Cu (G/Cu) nanocomposite under uniaxial tension are studied by molecular dynamics (MD) method strain rate dependence is also investigated. Firstly, through comparative analysis tensile results single crystal copper (Cu), slice (SSG/Cu) double (DSG/Cu) nanocomposite, it found that G/Cu nanocomposites have larger initial equivalent modulus ultimate strength...